A5115588959- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Horticultural and Viticultural Research
- Plant Physiology and Cultivation Studies
- Advanced Topics in Algebra
- Advanced Algebra and Geometry
- Cancer-related molecular mechanisms research
- Advanced Vision and Imaging
- Head and Neck Anomalies
- Organic Electronics and Photovoltaics
- Teratomas and Epidermoid Cysts
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Postharvest Quality and Shelf Life Management
- Plant Pathogens and Fungal Diseases
- Oral and Maxillofacial Pathology
- Finite Group Theory Research
- Epigenetics and DNA Methylation
- Analytical Chemistry and Sensors
- Chaos-based Image/Signal Encryption
- Urologic and reproductive health conditions
- Plant tissue culture and regeneration
Rural Development Administration
2010-2024
Yonsei University
2009-2024
American Institutes for Research
2024
Harvard University
2020-2024
Chonnam National University Hwasun Hospital
2015-2024
Dongguk University
2014-2024
Chung-Ang University Hospital
2022-2024
Citrus Research Institute
2024
Chungnam National University
2006-2024
Sangmyung University
2023-2024
Purpose: To retrospectively evaluate the diagnostic accuracy of ultrasonographic (US) criteria for depiction benign and malignant thyroid nodules by using tissue diagnosis as reference standard. Materials Methods: This study had institutional review board approval, informed consent was waived. From January 2003 through June 2003, 8024 consecutive patients undergone US at nine affiliated hospitals. A total 831 (716 women, 115 men; mean age, 49.5 years ± 13.8 [standard deviation]) with 849...
The selective detection of the anion pyrophosphate (PPi) is a major research focus. PPi biologically important target because it product ATP hydrolysis under cellular conditions, and involved in DNA replication catalyzed by polymerase, its being investigated as real-time sequencing method. In addition, within past decade, ability to detect has become cancer research. general, sensing anions aqueous solution requires strong affinity for water well convert recognition into fluorescent or...
The mammalian cytoplasmic protein SirT2 is a member of the Sir2 family NAD + -dependent deacetylases involved in caloric restriction-dependent life span extension. We found that and its yeast counterpart Hst2 have strong preference for histone H4K16Ac their deacetylation activity vitro vivo. pinpointed decrease global levels during cell cycle to G 2 /M transition coincides with localization on chromatin. Mouse embryonic fibroblasts (MEFs) deficient show higher mitosis, contrast normal...
Metabolic profiling of cancer cells has recently been established as a promising tool for the development therapies and identification biomarkers. Here we characterized metabolomic profile human breast tumors uncovered intrinsic metabolite signatures in these using an untargeted discovery approach validation key metabolites. The oncometabolite 2-hydroxyglutarate (2HG) accumulated at high levels subset cell lines. We discovered association between increased 2HG MYC pathway activation cancer,...
To assess changes in choroidal thickness type 2 diabetic patients with retinopathy (DR) and macular edema (DME) using enhanced-depth imaging spectral domain optical coherence tomography (EDI-OCT).Among 235 eyes from 145 patients, 195 treatment-naïve were divided into no DR, mild/moderate nonproliferative DR (NPDR), severe NPDR, proliferative (PDR), 40 having a history of laser panretinal photocoagulation (PRP) classified as PRP-treated DR. Eyes ocular treatment (195 eyes) according to the...
Inducible nitric oxide synthase (NOS2) is involved in wound healing, angiogenesis, and carcinogenesis. NOS2 upregulation increased (NO) production affect the redox state of cells can induce protein, lipid, DNA modifications. To investigate whether levels influence survival breast cancer patients, we examined expression its association with tumor markers 248 tumors. In multivariable analysis, predicted inferior women estrogen receptor α-negative (ER-negative) Microdissected epithelium from...
Background African-American breast cancer patients experience higher mortality rates than European-American despite having a lower incidence of the disease. We tested hypothesis that intrinsic differences in tumor biology may contribute to this health disparity. Methods and Results Using laser capture microdissection, we examined genome-wide mRNA expression specific epithelium stroma 18 17 patients. Numerous genes were differentially expressed between these two patient groups two-gene...
We previously reported that miR-1 is among the most consistently down-regulated miRs in primary human prostate tumors. In this follow-up study, we further corroborated finding an independent data set and made novel observation expression reduced distant metastasis a candidate predictor of disease recurrence. Moreover, performed vitro experiments to explore tumor suppressor function miR-1. Cell-based assays showed epigenetically silenced cancer. Overexpression these cells led growth...
Abstract The factors that determine whether a breast carcinoma will develop into inflammatory cancer (IBC) remain poorly understood. Recent evidence indicates the tumor stroma influences phenotypes. We tested hypotheses gene expression signature of is distinctive feature IBC. used laser capture microdissection to obtain enriched populations epithelial cells and adjacent stromal from 15 patients with IBC 35 invasive, noninflammatory (non‐IBC). Their mRNA profiles were assessed using...
Abstract Background Perineural invasion (PNI) is the dominant pathway for local in prostate cancer. To date, only few studies have investigated molecular differences between tumors with PNI and those without it. Methods evaluate involvement of both microRNAs protein‐coding genes PNI, we determined their genome‐wide expression a custom microRNA microarray Affymetrix GeneChips 50 adenocarcinomas 7 In situ hybridization (ISH) immunohistochemistry was used to validate candidate genes. Results...
MIF is a proinflammatory cytokine and implicated in cancer. A higher level found many human cancer cancer-prone inflammatory diseases, including chronic pancreatitis pancreatic We tested the hypothesis that contributes to aggressiveness predicts disease outcome resected cases. Consistent with our we an elevated mRNA expression tumors was significantly associated poor Multivariate Cox-regression analysis further showed independently patients' survival (HR = 2.26, 95% CI 1.17-4.37, p 0.015)....
The aim of the present study was to evaluate more effective therapy for postsurgical gastroesophageal leakage by a head-to-head comparison endoscopic vacuum (EVT) and stent implantation with self-expandable metal (E-SEMS). In this hospital-based, retrospective, observative study, patients were classified into 2 groups. Those treated EVT assigned group (n = 7), those E-SMS E-SEMS 11). We evaluated clinical characteristics treatment outcomes between All 7 (100%) EVT, but only 11 (63.6%) in...
Purpose.: To investigate the correlation between subfoveal choroidal thickness (SFChT) and severity or progression of nonexudative AMD.
Objective: The authors analyzed the clinical features and treatment results of surgical patients with a final diagnosis dermoid cyst on floor mouth over 14 years at our hospital. Patients Methods: A total 5 from January 2010 to December 2023 were enrolled. Results: All complained swelling in submentum or mouth. mean tumor size was 4.2±1.0 cm. underwent complete resection. transcervical approach performed 3 patients, an intraoral implemented 2 patients. There no major complications after...
A new fluorescent sensor based on a pyrene/ZnII–dpa (dpa = bis(2-pyridylmethyl)amine) conjugate displays excimer emission selective for pyrophosphate over other anions.
A common single-nucleotide polymorphism (SNP) in the promoter region of MDM2 gene, known as T-309G and referred to SNP309 for this study, leads increased expression Mdm2 protein attenuated function p53 tumor suppressor protein. We investigated whether genetic variants were associated with breast cancer incidence survival variant status could interact modify survival.We used multivariable logistic Cox regression analyses study relationship a second SNP exon 12 at codon 354 (SNP354)...
Although food waste (FW) can serve as a valuable substrate containing large amounts of organic materials such soluble sugar, starch, and cellulose, it is recognized an environmental pollutant, the hydrolysis solids in FW still serves rate-limiting step its biological processes. To evaluate new potential application alternative for ethanol production through laboratory experiments, we investigated by using individual commercial enzymes their mixtures; batch fermentation Saccharomyces...
Metabolic reprogramming in breast tumors is linked to increases putative oncogenic metabolites that may contribute malignant transformation. We previously showed accumulation of the oncometabolite, 2-hydroxyglutarate (2HG), was associated with MYC signaling, but not isocitrate dehydrogenase (IDH) mutations, suggesting a distinct mechanism for increased 2HG cancer. Here, we determined D-2HG predominant enantiomer human and show D-2HG–producing mitochondrial enzyme, alcohol dehydrogenase,...