A5081615589- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- Microwave Engineering and Waveguides
- Genomics and Chromatin Dynamics
- Lipid metabolism and biosynthesis
- Cell Adhesion Molecules Research
- Bladder and Urothelial Cancer Treatments
- GNSS positioning and interference
- Metabolism, Diabetes, and Cancer
- Acute Myeloid Leukemia Research
- Pancreatic function and diabetes
- Millimeter-Wave Propagation and Modeling
- Eosinophilic Disorders and Syndromes
- Ionosphere and magnetosphere dynamics
- Fungal Plant Pathogen Control
- Pediatric Hepatobiliary Diseases and Treatments
- RNA modifications and cancer
- Trace Elements in Health
- Geophysics and Gravity Measurements
- Ubiquitin and proteasome pathways
- Antenna Design and Analysis
University of Burdwan
2024
Baylor College of Medicine
2003-2016
Brown Foundation
2008-2012
Center for Human Genetics
2012
The University of Texas Health Science Center at Houston
2007-2011
The University of Texas MD Anderson Cancer Center
2005
Metabolic profiling of cancer cells has recently been established as a promising tool for the development therapies and identification biomarkers. Here we characterized metabolomic profile human breast tumors uncovered intrinsic metabolite signatures in these using an untargeted discovery approach validation key metabolites. The oncometabolite 2-hydroxyglutarate (2HG) accumulated at high levels subset cell lines. We discovered association between increased 2HG MYC pathway activation cancer,...
Abstract The precise molecular alterations driving castration-resistant prostate cancer (CRPC) are not clearly understood. Using a novel network-based integrative approach, here, we show distinct in the hexosamine biosynthetic pathway (HBP) to be critical for CRPC. Expression of HBP enzyme glucosamine-phosphate N-acetyltransferase 1 ( GNPNAT1 ) is found significantly decreased CRPC compared with localized (PCa). Genetic loss-of-function CRPC-like cells increases proliferation and...
We used human bladder cancer as a model system and the whole-organ histologic genetic mapping strategy to identify clonal hits associated with growth advantage, tracking evolution of from intraurothelial precursor lesions. Six putative chromosomal regions critical for expansion neoplasia development were identified by using this approach. Focusing on one regions, which includes tumor suppressor RB1 , we performed allelotyping single-nucleotide polymorphic sites 1.34-Mb segment around...
Understanding the structure and function of ATP-binding cassette (ABC) transporters is very important because defects in ABC lie at root several serious diseases including cystic fibrosis. MalK, maltose transporter Escherichia coli, distinct from most other cassettes that it contains an additional C-terminal regulatory domain. The published a MalK dimer elongated with domains opposite poles (Diederichs, K., Diez, J., Greller, G., Muller, C., Breed, Schnell, Vonrhein, Boos, W., Welte, W....
Background Sequence variation in the human 12/15 lipoxygenase (ALOX15) has been associated with atherosclerotic disease. We functionally characterized an ALOX15 promoter polymorphism, rs2255888, previously carotid plaque burden. Methodology/Principal Findings demonstrate specific vitro and vivo binding of cytoskeletal protein, vimentin, to promoter. show that two haplotypes carrying alternate alleles at rs2255888 exhibit significant differences activity by luciferase reporter assay cell...
Abstract Prostate Cancer is the second most common cause of cancer-related death in men US. Like other tumors, prostate cancer development and progression dictated by multiple molecular events that include changes levels genes, transcripts, proteins metabolites. To better understand biology it essential to integrate these disparate yet related datasets. Our laboratory has identified matched transcriptomic, proteomic metabolomic localized relative adjacent benign tissue as well metastatic...
Abstract Prostate Cancer (PCa) is the second highest cause of cancer-related death in men US. PCa androgen dependent when organ-confined and conventionally treated using surgery or a combination anti-androgens radiation therapy. However, about 30% patients tumor recurs are initially administered deprivation therapy (ADT). Majority become resistant to ADT develop hormone-refractory disease also termed castration-resistant prostate cancer (CRPC), which lethal. Currently, molecular biochemical...
Human 12/15-lipoxygenase (ALOX15) catalyzes the oxidation of polyunsaturated fatty acids and has been implicated in pathogenesis atherosclerosis. We previously reported that a common haplotype ALOX15 gene is associated with higher prevalence coronary artery calcification cohort middle-aged African-Americans. This was uniquely tagged by promoter variant (rs2255888). carried out an vitro characterization this to further investigate regulatory mechanisms gene. evaluated activity A-carrying wild...
Abstract Large variations in breast cancer incidence and survival among the various population groups United States continue to exist differences clinical presentation of disease between African American (AA) European-American women have been recognized. Specifically, AA develop at a relatively younger age, two-fold increased risk developing triple-negative (TN) tumors present more commonly with stage IV disease, when compared EA women. While precise reasons for this disparity are still...