A5019648757- Retinal Diseases and Treatments
- Drug-Induced Ocular Toxicity
- Systemic Lupus Erythematosus Research
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Biomedical Research and Pathophysiology
- Retinal Imaging and Analysis
- Neonatal Health and Biochemistry
- Intraocular Surgery and Lenses
- Genetic Associations and Epidemiology
- Retinal and Optic Conditions
- Methemoglobinemia and Tumor Lysis Syndrome
- Amino Acid Enzymes and Metabolism
- Acute Ischemic Stroke Management
- Connexins and lens biology
- Ocular Surface and Contact Lens
- Neuroscience of respiration and sleep
- Ocular Infections and Treatments
- Eosinophilic Esophagitis
- Retinal Development and Disorders
- Asthma and respiratory diseases
- Hormonal Regulation and Hypertension
- Retinal and Macular Surgery
Colorado Permanente Medical Group
2022-2025
Kaiser Permanente Redwood City Medical Center
2015-2024
Kaiser Permanente
2014-2024
University of Findlay
2023
Koch Foundation
2023
Dr.Techn.Olav Olsen (Norway)
2023
University of California, San Diego
1987-1991
University of California, San Francisco
1990
Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations risk were low based largely on short-term users or severe retinal toxicity (bull's eye maculopathy). The may be much higher because retinopathy detected earlier when using more sensitive screening techniques.To reassess prevalence and factors hydroxychloroquine to determine dosage levels that facilitate safe use drug.Retrospective...
The relationship between outpatient systolic and diastolic blood pressure cardiovascular outcomes remains unclear has been complicated by recently revised guidelines with two different thresholds (≥140/90 mm Hg ≥130/80 Hg) for treating hypertension.Using data from 1.3 million adults in a general population, we performed multivariable Cox survival analysis to determine the effect of burden hypertension on composite outcome myocardial infarction, ischemic stroke, or hemorrhagic stroke over...
Abstract Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, leading cause of blindness. IOP heritability has been estimated to up 67%, and date only 11 loci have reported, accounting 1.5% variability. Here, we conduct genome-wide association study in 69,756 untreated individuals European, Latino, Asian, African ancestry. Multiple longitudinal measurements were collected through electronic health records and, total, 356,987 included. We identify 47 significant...
Four major medical societies involved with hydroxychloroquine (HCQ) therapy concur on the need for common principles and cooperation to minimize risk of ocular toxicity. At a daily dosage ≤5 mg/kg/day actual body weight, retinal toxicity from HCQ is <2% usage up 10 years. Widespread adoption more sensitive testing techniques, such as optical coherence tomography automated visual fields, by eye care providers will allow detection early thus preserve patient's function. Baseline advised rule...
Hydroxychloroquine is recommended for all patients with systemic lupus erythematosus and often used other inflammatory conditions, but a critical long-term adverse effect vision-threatening retinopathy.To characterize the risk incident hydroxychloroquine retinopathy examine degree to which average dose within first 5 years of treatment predicts this risk.Cohort study.U.S. integrated health network.All aged 18 or older who received more between 2004 2020 had guideline-recommended serial...
Importance The major toxic effect of hydroxychloroquine is retinopathy. Thus, current guidelines recommend limiting the dose and screening annually for retinopathy among all long-term users, but individual patient factors may be associated with risk. Objective To identify risk beyond duration use Design, Setting, Participants This cohort study 4677 patients in Kaiser Permanente Northern California integrated health network who initiated hydroxychloroquine, continued treatment, underwent...
Purpose: To compare the accuracy of intraocular lens (IOL) power calculation formula predictions (Barrett Universal II, Emmetropia Verifying Optical [EVO] 2.0, Haigis, Hill-RBF Holladay 1, 2, Hoffer Q, Kane, Olsen, and SRK/T) when using Alcon SA60AT IOL 30 or greater diopter (D) power. Setting: Kaiser Permanente, California, USA. Design: Multicenter retrospective consecutive case series. Methods: Data from patients having uneventful cataract surgery with insertion a ≥30 D preoperative...