Background: A recent surge in knee replacements is assumed to be due aging and increased obesity of the U.S. population. Objective: To assess whether age, obesity, change radiographic osteoarthritis explain trend pain osteoarthritis. Design: Cross-sectional, using data from 6 NHANES (National Health Nutrition Examination Survey) surveys between 1971 2004 3 examination periods FOA (Framingham Osteoarthritis) Study 1983 through 2005. Setting: Participants: participants (white or African...

To examine the relationship between longitudinal fluctuations in synovitis with change pain and cartilage knee osteoarthritis.Study subjects were patients 45 years of age older symptomatic osteoarthritis from Boston Osteoarthritis Knee Study. Baseline follow-up assessments at 15 30 months included magnetic resonance imaging (MRI), BMI assessment (VAS) over last week. Synovitis was scored 3 locations (infrapatellar fat pad, suprapatellar intercondylar regions) using a semiquantitative scale...

Abstract Objective To explore the role of meniscal tears and malposition as risk factors for subsequent cartilage loss in subjects with symptomatic osteoarthritis (OA). Methods Study were patients knee OA from Boston Osteoarthritis Knee Study. Baseline assessments included magnetic resonance imaging (MRI) followup MRI at 15 30 months. Cartilage damage scored on medial lateral tibiofemoral joints using semiquantitative whole‐organ score. Tibiofemoral was MR images all 5 plates each joint,...

To examine use of magnetic resonance imaging (MRI) knees with no radiographic evidence osteoarthritis to determine the prevalence structural lesions associated and their relation age, sex, obesity.Population based observational study.Community cohort in Framingham, MA, United States (Framingham study).710 people aged >50 who had knee (Kellgren-Lawrence grade 0) underwent MRI knee.Prevalence findings that are suggestive (osteophytes, cartilage damage, bone marrow lesions, subchondral cysts,...

To describe the prevalence and longitudinal course of radiographic, erosive symptomatic hand osteoarthritis (HOA) in general population.Framingham (OA) study participants obtained bilateral radiographs at baseline 9-year follow-up. The authors defined radiographic HOA joint level as Kellgren-Lawrence grade (KLG)≥2, KLG≥2 plus erosion pain/aching/stiffness. Presence individual was ≥1 affected joint. age-standardised (US 2000 Population 40-84 years).Mean (SD) age 58.9 (9.9) years (56.5%...

Abstract Objective Results of cross‐sectional studies have suggested that bone marrow lesions (BMLs) visualized on magnetic resonance imaging (MRI) are related to knee pain, but no longitudinal been done. This study was undertaken determine whether enlarging BMLs associated with new pain. Methods Subjects ages 50–79 years osteoarthritis (OA) or at high risk OA were asked twice baseline about the presence aching, stiffness (classified as frequent pain) most days; absence pain eligibility...

Abstract Objective Although bone marrow lesions (BMLs) are powerful predictors of joint space loss as visualized on radiographs, the natural history these lesions, their relationship to cartilage loss, and association between change in unknown. These questions were tested using longitudinal magnetic resonance imaging (MRI) data a study symptomatic knee osteoarthritis (OA). Methods MRI was performed at baseline, 15 months, 30 months 217 patients with primary OA (122 men, 95 women; mean ± SD...

<b>Objective</b> To examine the relation of radiographic features osteoarthritis to knee pain in people with knees discordant for two cohorts. <b>Design</b> Within person, matched, case-control study. <b>Setting and participants</b> Participants Multicenter Osteoarthritis (MOST) Framingham studies who had radiographs assessments pain. <b>Main outcome measures</b> Association each measure (frequency, consistency, severity) osteoarthritis, as assessed by Kellgren Lawrence grade (0-4)...

Objective To estimate the prevalence of symptomatic knee osteoarthritis (OA) in China. Methods Using data collected from China Health and Retirement Longitudinal Study, a population‐based longitudinal survey conducted between 2011 2012, we estimated OA according to sex, age, rural/urban area, socioeconomic status, geographic region. Results Among 17,128 individuals (8,367 men 8,761 women; mean age 59.8 years) included analysis, 8.1% had OA. The was higher women (10.3%) compared with (5.7%)...

Objective To evaluate if two different measures of synovial activation, baseline Hoffa synovitis and effusion synovitis, assessed by MRI, predict cartilage loss in the tibiofemoral joint at 30 months follow-up subjects with neither damage nor radiographic osteoarthritis knee. Methods Non-contrast-enhanced MRI was performed using proton density-weighted fat-suppressed sequences axial sagittal planes a short tau inversion recovery sequence coronal plane. status were semiquantitatively...

Fluctuations in pain patients with knee osteoarthritis (OA) are common, but risk factors for fluctuation poorly understood. To best identify the structural causes of fluctuations, multiple assessments status and lesions needed. This study was undertaken to determine whether resolution is accompanied by diminution OA.Subjects Multicenter Osteoarthritis Study were queried about their interview, knees assessed magnetic resonance imaging at baseline 15-month 30-month clinic visits. For those...

<h3>Background</h3> It has been suggested that synovitis causes joint pain. On non-contrast-enhanced MRIs synovial thickening cannot be assessed and on these images inconsistently associated with <h3>Objective</h3> To assess in relation to knee pain severity among subjects the Multicenter Osteoarthritis Study (MOST) using contrast-enhanced (CE) MRI. <h3>Methods</h3> MOST is a cohort study of people who have, or are at high risk of, <i>osteoarthritis</i> (OA). An unselected subset 535...

Abstract Objective To determine the effect of quadriceps strength in individuals with knee osteoarthritis (OA) on loss cartilage at tibiofemoral and patellofemoral joints (assessed by magnetic resonance imaging [MRI]) pain function. Methods We studied 265 subjects (154 men 111 women, mean ± SD age 67 9 years) who met American College Rheumatology criteria for symptomatic OA were participating a prospective, 30‐month natural history study OA. Quadriceps was measured baseline, isokinetically,...

To describe the natural history of subchondral bone marrow lesions (BMLs) in a sample subjects with knee osteoarthritis (OA) or at risk developing it. Additionally, to examine association change BMLs from baseline 30-month follow-up cartilage loss same subregion follow-up.1.0 T MRI was performed using proton density-weighted, fat-suppressed sequences. BML size and status were scored subregions according WORMS system. Subregions categorised based on comparison status. A logistic regression...

To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression. We measured mechanical axis from long limb radiographs Multicenter Osteoarthritis Study (MOST) Initiative (OAI) to define limbs with (mechanical ≥1.1° valgus) examined alignment versus neutral (neither varus nor OA structural outcomes. Posteroanterior magnetic resonance (MR) images were obtained at time radiograph followup examinations. Lateral progression was defined as an increase in joint...

Abstract Objective Gait speed is an important marker of health in adults and slows with aging. While knee osteoarthritis (OA) can result difficulty walking, it not known if radiographic OA (ROA) and/or pain are associated a fast decline trajectory gait over time. Methods trajectories were constructed using multinomial modeling strategy from repeated 20‐meter walk tests measured annually 4 years among participants the Osteoarthritis Initiative, prospective cohort study ages 45–79 at baseline...

Objective Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but its cause humans not well understood. We examined whether inflammation, assessed as synovitis and effusion on magnetic resonance imaging (MRI), or mechanical load, bone marrow lesions (BMLs), was OA. Methods Subjects the Multicenter Osteoarthritis Study, a National Institutes of Health–funded cohort persons at risk OA, underwent radiography MRI knee, standardized quantitative sensory testing...

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Death with graft function remains an important cause of loss among kidney transplant recipients (KTRs). Little is known about the trend specific causes death in KTRs recent years. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We analyzed United States Renal Data System data (1996–2014) to determine 1- and 10-year all-cause cause-specific mortality adult who died a functioning allograft. also studied trends various mortality....

Whereas obesity increases overall loading of the knee, limb malalignment concentrates that on a focal area, to level at which cartilage damage may occur. This study evaluated whether effect body weight progression knee osteoarthritis (OA) differs depending degree malalignment.The population comprised 228 veterans and community recruits with symptomatic OA (pain most days radiographic disease) who volunteered participate in natural history from whom baseline radiographs were obtained assess...

Abstract Objective To explore the relative contribution of hyaline cartilage morphologic features and meniscus to radiographic joint space. Methods The Boston Osteoarthritis Knee Study is a natural history study symptomatic knee osteoarthritis (OA). Baseline 30‐month followup assessments included magnetic resonance imaging (MRI) fluoroscopically positioned weight‐bearing radiographs. Cartilage meniscal degeneration were scored on MRI in medial lateral tibiofemoral joints using...

Abstract Objective To examine whether obesity increases the risk of progression knee osteoarthritis (OA). Methods We used data from Multicenter Osteoarthritis Study, a longitudinal study persons with or at high OA. OA was characterized baseline and 30 months using posteroanterior fixed‐flexion radiographs Kellgren/Lawrence (K/L) grading, alignment assessed on full‐extremity films. In knees (K/L grade 2 3), defined as tibiofemoral joint space narrowing 30‐month radiograph. without 0 1),...

Abstract Objective To determine the relationship between radiographic progression of joint space narrowing and cartilage loss on magnetic resonance imaging (MRI) in patients with symptomatic knee osteoarthritis (OA), to investigate location MRI‐based its relation progression. Methods Two hundred twenty‐four men women (mean age 66 years) were studied. Radiographs MRI more obtained at baseline 15‐ 30‐month followup. (with weight‐bearing) read for (scale 0–3), defined as any worsening score. We...

Abstract Objective To assess whether knee extensor strength or hamstring:quadriceps (H:Q) ratio predicts risk for incident radiographic tibiofemoral and symptomatic whole osteoarthritis (OA) in adults ages 50–79 years. Methods We followed 1,617 participants (2,519 knees) who, at the baseline visit of Multicenter Osteoarthritis (MOST) Study, did not have OA 2,078 (3,392 who (i.e., combination frequent symptoms). Isokinetic was measured baseline, were development OA, 30 months. Generalized...