A5089167470- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Musculoskeletal pain and rehabilitation
- Hip disorders and treatments
- Muscle activation and electromyography studies
- Shoulder Injury and Treatment
- Tendon Structure and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Sports injuries and prevention
- Pregnancy-related medical research
- Diabetic Foot Ulcer Assessment and Management
- Rheumatoid Arthritis Research and Therapies
- Balance, Gait, and Falls Prevention
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal Disorders and Rehabilitation
- Pain Mechanisms and Treatments
- Orthopedic Surgery and Rehabilitation
- Clinical practice guidelines implementation
- Orthopaedic implants and arthroplasty
- Cardiovascular and exercise physiology
- Sports Performance and Training
- Bone and Joint Diseases
- Allergic Rhinitis and Sensitization
University of Kansas
2015-2024
University of Iowa
2014-2024
University of Kansas Medical Center
2016-2024
Northwestern University
2016-2024
University of Southern California
2016-2023
University Medical Center
2001-2021
University of California, San Francisco
2010-2020
University of Alabama at Birmingham
2015-2020
Rabin Medical Center
1999-2020
Foundation for Physical Medicine and Rehabilitation
2018-2020
Objective Varus and valgus alignment increase medial lateral tibiofemoral load. Alignment was associated with osteoarthritis progression in previous studies; an effect on incident risk is less certain. This study tested whether influences the of progressive radiographic osteoarthritis. Methods In observational, longitudinal Multicenter Osteoarthritis Study cohort, full-limb x-rays to measure were acquired at baseline knee 30 months. defined as ≤178° ≥182°. Using logistic regression...
To study the effect of valgus malalignment on knee osteoarthritis (OA) incidence and progression. We measured mechanical axis from long limb radiographs Multicenter Osteoarthritis Study (MOST) Initiative (OAI) to define limbs with (mechanical ≥1.1° valgus) examined alignment versus neutral (neither varus nor OA structural outcomes. Posteroanterior magnetic resonance (MR) images were obtained at time radiograph followup examinations. Lateral progression was defined as an increase in joint...
Abstract Objective To assess whether knee extensor strength or hamstring:quadriceps (H:Q) ratio predicts risk for incident radiographic tibiofemoral and symptomatic whole osteoarthritis (OA) in adults ages 50–79 years. Methods We followed 1,617 participants (2,519 knees) who, at the baseline visit of Multicenter Osteoarthritis (MOST) Study, did not have OA 2,078 (3,392 who (i.e., combination frequent symptoms). Isokinetic was measured baseline, were development OA, 30 months. Generalized...
Sleep complaints are among the commonest in medical practice and can be simply categorised as: ▶disturbances of getting to sleep or staying asleep, unrefreshing sleep, that is insomnia, ▶excessive daytime (or more properly wake-time) sleepiness, is, hypersomnia; ▶things disturb individual9s commonly said "things go bump night", parasomnias. Although insomnia parasomnias prevalent, hypersomnias considered prominently because potential impact on household society. Conditions will produce...
Background There are no controlled studies testing the efficacy of various nonoperative strategies for treatment greater trochanter pain syndrome. Hypothesis The null hypothesis was that local corticosteroid injection, home training, and repetitive low-energy shock wave therapy produce equivalent outcomes 4 months from baseline. Study Design Randomized clinical trial; Level evidence, 2. Methods Two hundred twenty-nine patients with refractory unilateral syndrome were assigned sequentially to...
<h3>PURPOSE</h3> Knee osteoarthritis is a common, debilitating chronic disease. Prolotherapy an injection therapy for musculoskeletal pain. We conducted 3-arm, blinded (injector, assessor, group participants), randomized controlled trial to assess the efficacy of prolotherapy knee osteoarthritis. <h3>METHODS</h3> Ninety adults with at least 3 months painful were (dextrose or saline) at-home exercise. Extra- and intra-articular injections done 1, 5, 9 weeks as-needed additional treatments 13...
Impaired quadriceps strength and joint position sense (JPS) have been linked with knee osteoarthritis (OA) cross-sectionally. Although neither has independently associated incident radiographic OA, their combination may mediate risk. The purpose of this study was to determine whether better sensorimotor function protects against the development or symptomatic OA.The Multicenter Osteoarthritis is a longitudinal adults aged 50–79 yr at high risk for OA. Participants underwent bilateral,...
Abstract Objective To assess whether concurrent blood flow restriction (BFR) during low‐load resistance training is an efficacious and tolerable means of improving quadriceps strength volume in women with risk factors for symptomatic knee osteoarthritis (OA). Design Randomized, double‐blinded, controlled trial. Setting Exercise clinical research laboratory. Participants Women over age 45 years OA. Methods were randomized to either (30% 1RM) alone (control) or BFR completed 4 weeks 3 times...
Objectives Meniscal pathology in which the aetiology is often unclear a frequent finding on knee MRI. This study investigates potential risk factors for medial meniscal lesions or extrusion middle-aged and elderly persons. Methods Prospective cohort using population-based subjects from Birmingham, Alabama Iowa City, Iowa, USA (the Multicenter Osteoarthritis Study). 644 men women aged 50–79 years with at high of osteoarthritis (Kellgren Lawrence grade 0–2) but normal status baseline were...
ObjectiveTo determine whether quadriceps weakness is associated with elevated risk of worsening knee pain over 5 years.MethodsThe Multicenter Osteoarthritis Study (MOST) a longitudinal study 50–79-year-old adults osteoarthritis (OA) or known factors for OA. The predictor variable was baseline isokinetic strength. Covariates included body mass index (BMI), physical activity level, and history surgery. outcome reported on the Western Ontario McMaster Universities (WOMAC) Index subscale...
Evaluate the efficacy and safety/tolerability of cryoneurolysis for reduction pain symptoms associated with knee osteoarthritis (OA).Randomized, double-blind, sham-controlled, multicenter trial a 6-month follow-up in patients mild-to-moderate OA. Patients were randomized 2:1 to targeting infrapatellar branch saphenous nerve (IPBSN) or sham treatment. The primary endpoint was change from baseline Day 30 Western Ontario McMaster Osteoarthritis Index (WOMAC) score adjusted by site. Secondary...
Abstract We studied whether contact stress estimates from knee magnetic resonance images (MRI) predict the development of incident symptomatic tibiofemoral osteoarthritis (OA) 15 months later in an at‐risk cohort. This nested case‐control study was conducted within a cohort 3,026 adults, age 50 to79 years. Thirty cases with OA by their month follow‐up visit were randomly selected and matched 30 control subjects. Symptomatic defined as daily pain/stiffness Kellgren‐Lawrence Grade ≥2 on weight...
Objectives: Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident knee osteoarthritis (OA) defined by osteophytes but not joint space narrowing (JSN), and are inconsistent regarding BMD progression of existing OA. The association progressive tibiofemoral OA was tested in a large prospective study men women aged 50–79 years or at risk for Methods: Baseline 30-month weight-bearing posteroanterior lateral radiographs were scored Kellgren-Lawrence...
Women are disproportionately affected by musculoskeletal disorders. Parous women seem to be at a particularly elevated risk for structural and functional changes in the lower limbs. The combination of increased weight on joints with potentially greater laxity during pregnancy could lead permanent feet. Although arches may become lax pregnancy, it is unknown whether persist. objective this study was determine arch height loss persists postpartum.Forty-nine completed longitudinal study. Static...