A5057333101- Synthetic Organic Chemistry Methods
- Family and Patient Care in Intensive Care Units
- Intensive Care Unit Cognitive Disorders
- Health and Wellbeing Research
- Anesthesia and Sedative Agents
- Asymmetric Synthesis and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Diverse Approaches in Healthcare and Education Studies
- Healthcare Education and Workforce Issues
- Microbial Natural Products and Biosynthesis
- Magnolia and Illicium research
- Consumer Perception and Purchasing Behavior
- Oxidative Organic Chemistry Reactions
- Advanced Synthetic Organic Chemistry
- Marine Sponges and Natural Products
- Marine and Coastal Research
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Phytochemical compounds biological activities
- Dielectric materials and actuators
- Technology Adoption and User Behaviour
- Elbow and Forearm Trauma Treatment
- Marine Toxins and Detection Methods
- Diverse Topics in Contemporary Research
Youngsan University
2019-2024
Dong-A University
2019-2024
Dong-Eui University
2023
Soonchunhyang University Hospital
2019-2021
Korea National University of Education
2021
Kosin University Gospel Hospital
2014-2020
Kangwon National University
2014
Novartis (Switzerland)
2009-2010
Monell Chemical Senses Center
1998-2007
Philadelphia University
2002-2007
Identification and structure-guided optimization of a series 4-(pyrazol-4-yl)-pyrimidines as selective CDK4/6 inhibitors is reported herein. Several potency selectivity determinants were established based on the X-ray crystallographic analysis representative compounds bound to monomeric CDK6. Significant for over CDK1 CDK2 was demonstrated with several in both enzymatic cellular assays.
The goal of this study is to assess the influences that Korean pop culture has on Hong Kong residents' perceptions Korea as a potential tourist destination. Among 500 distributed questionnaires, 456 were collected. Finally, 440 usable surveys used for data analysis after eliminating 16 questionnaires with multiple missing answers deemed unusable. Data analyses produced many meaningful results. For example, respondents who less educated and tended spend more cultural products had higher...
The total synthesis of jiadifenin has been accomplished. allows us to build an SAR profile which suggests that the skeleton may be less desirable from standpoint nominating a potential drug than its prerearrangement precursor. key steps problem involve construction two 1,3-related quaternary carbons. paper describes how stereochemistry was managed in this context. issue studied considerable detail at level then new allyl transfer reaction arising palladium-mediated process carbonate. By use...
The purpose of this study was to develop a scale measure person-centered critical care nursing and verify its reliability validity.A total 38 preliminary items on were selected using content validity analysis expert opinion 72 candidate derived through literature review qualitative interviews. We conducted questionnaire survey with 477 nurses who worked in intensive units. collected data analyzed exploratory factor (EFA) confirmative (CFA) SPSS AMOS 24.0 program.EFA performed principal axis...
A convergent, stereocontrolled total synthesis of the architecturally complex tremorgenic indole alkaloid (−)-penitrem D (4) has been achieved. Highlights include an efficient, asymmetric western hemisphere; assembly I-ring; discovery a novel autoxidation to introduce C(22) tertiary hydroxyl group, required for activity; union fully elaborated eastern and hemispheres, exploiting synthetic protocol developed expressly this purpose; late-stage, stereoselective construction F rings...
We report the first total synthesis of jiadifenin (1), establishment a modality for its biological evaluation, and discovery apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1.
A modification of the Wacker oxidation terminal olefins to methyl ketones using substoichiometric amounts Cu(OAc)2 as a redox shuttle reagent is described. The modified procedure generally high yielding despite reduced levels copper salt and convenient. Importantly, in problematic case, conditions suppressed acidic hydrolysis during substrate (+)-5 containing an acetonide.
ABSTRACT We report here on the case of a child who was infected with scrub typhus, and we made diagnosis according to serology by performing PCRs child's eschar. The patient treated azithromycin, he did not experience any complications. Performing nested PCR eschar might be both rapid diagnostic test for typhus in early acute stage differential as whether or scab is
A second-generation strategy for construction of (+)-nodulisporic acids and B based on the development a new, effective modular indole synthesis exploiting sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic is disclosed. This evolved due to considerable acid instability C(24) hydroxyl group observed in several advanced intermediates during our first-generation approach.
A first-generation strategy for construction of (+)-nodulisporic acids (1) and B (2) is described. The entails union the eastern western hemisphere subtargets via indole synthesis protocol developed in our laboratory. Subsequent elaboration rings E F, however, revealed considerable acid instability C(24) hydroxyl, thereby preventing further advancement. Nonetheless, preparation heptacyclic core B, total simplest member nodulisporic family, (−)-nodulisporic D were achieved.
Diffusion-controlled crystallization in a hydrogel has been investigated to synthesize organic/inorganic hybrid composites and obtain fundamental understanding of the detailed mechanism biomineralization. Although calcium phosphate/hydrogel have intensively studied developed for application bone substitutes, synthesis homogeneous integrated remains challenging. In this work, diffusion-controlled systems were optimized by manipulating ion flux at interface, concentration gradient, diffusion...
A scalable, second-generation synthesis of the densely functionalized eastern tricyclic lactone (+)-6, a common intermediate, for construction nodulisporic acids has been achieved. Modifications to first-generation route now permit access (+)-6 in 17 steps with an overall 16.5% yield. Key carbon−carbon bond constructions include Kirk−Petrow (phenylthio)methylation, Sc(OTf)3-catalyzed hydroxymethylation, Stille carbonylation, and Koga three-component, conjugate addition−alkylation sequence.
In this, the second of two Letters, we describe an effective assembly (+)-4, eastern hemisphere subtarget comprising FGH rings (+)-nodulisporic acid A (1) (17 steps, 9% overall yield). Central to synthesis is a Koga three-component conjugate addition−alkylation sequence which secures trans orientation vicinal quaternary methyl groups.
Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed synthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel scaffolds for design synthesis analogues.
Purpose : In this study, we aimed to identify factors influencing the inpatient satisfaction in integrated nursing care service wards. Methods Using data from 2020 and 2021 healthcare experience surveys conducted by Ministry of Health Welfare, study analyzed a weighted sample 416,020 participants using descriptive statistics, pairedt-test, Pearson’s correlation, multiple linear regression analyses. Results Inpatient wards was most significantly affected experiences with services perceived...
Abstract Aim To investigate the incidence of post‐intensive care unit (ICU) depression and its risk factors among critical survivors. Methods The study data were extracted from database National Health Insurance Service Korea. We retrospectively analyzed 161,977 adult patients who admitted to ICU for more than 24 hr January 1, 2012 December 31, 2014 survived 1 year after discharge. Risk newly diagnosed (Code F32) using multiple logistic regression analysis. Results post‐ICU was 18.5%. major...
PurposeThe purpose of this study was to culturally adapt the Intensive Care Experience Questionnaire (ICEQ) for Korean patients and evaluate its validity reliability.MethodsThis cross-sectional comprised two phases. The first phase involved cultural adaptation ICEQ. In second phase, psychometric properties adapted measure were evaluated. Cultural conducted in accordance with World Health Organization's process. questionnaire administered 200 who had received treatment an intensive care unit...