A5084081275- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- Education and Learning Interventions
- Pharmacological Effects and Toxicity Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Organ Transplantation Techniques and Outcomes
- Consumer Perception and Purchasing Behavior
- Food Quality and Safety Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal motility and disorders
- Estrogen and related hormone effects
- Educational Research and Pedagogy
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Education, Safety, and Science Studies
- Renal cell carcinoma treatment
- Lung Cancer Diagnosis and Treatment
- Boron Compounds in Chemistry
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Hepatocellular Carcinoma Treatment and Prognosis
- Urinary Bladder and Prostate Research
- Diverse Topics in Contemporary Research
- Diet and metabolism studies
Seoul National University
2014-2025
National Cancer Center
2011-2025
Ulsan College
2007-2025
Kyung Hee University Medical Center
2020-2025
University of Ulsan
2009-2025
Soonchunhyang University Hospital
2013-2025
Asan Medical Center
2010-2025
Kyungpook National University
2005-2025
Kyung Hee University
2015-2024
Pohang University of Science and Technology
2003-2024
Serious complications have occurred in a considerable proportion of living donors liver transplants, but data from single high-volume center has rarely been available. We analyzed the medical records and recipients first 1,000 donor performed at Asan Medical Center December 1994 to June 2005, with focus on safety. There were 107 pediatric 893 adult transplants. The most common diagnoses biliary atresia (63%) hepatitis B-associated cirrhosis (80%) recipients. Right lobe strictly selected...
To increase the oral bioavailability of curcumin and genistein, we fabricated nanostructured lipid carriers (NLCs), impact these on bioaccessibility genistein was studied. Entrapment efficiency more than 75% for and/or genistein-loaded NLCs. Solubility in simulated intestinal medium (SIM) >75% after encapsulating within NLCs which otherwise <20%. Both have shown good stability (≥85%) SIM gastric (SGM) up to 6 h. Coloading had no adverse effect solubility each molecule. Instead, coloading...
Lignocellulosic biomass is an attractive renewable resource for future liquid transport fuel. Efficient and cost-effective production of bioethanol from lignocellulosic depends on the development a suitable pretreatment system. The aim this study to investigate new method that highly efficient effective downstream biocatalytic hydrolysis various materials, which can accelerate commercialization.The optimal conditions hydrogen peroxide-acetic acid (HPAC) were 80 °C, 2 h, equal volume mixture...
Background. Left liver graft from a small donor will not meet the metabolic demands of larger adult recipient. One solution to this problem is use right without middle hepatic vein (MHV). However, need for drainage MHV tributaries has yet been described. Methods. Five grafts were transplanted in patients including two hepatitis B virus-cirrhosis, fulminant failure and one secondary biliary cirrhosis. The weight ranged 650 1000 g, corresponding 48 83% standard volume recipients. Results. Two...
A considerable proportion of adult living donor liver transplantation (LDLT) recipients experience biliary complication (BC), but there are few reports regarding BC based on long-term studies a large LDLT population. The present study examined incidence, risk factors and management using single-center data from 259 patients (225 right 34 left grafts) between 2000 2002. mean follow-up period was 46 +/- 14 months. Biliary reconstruction included single duct-to-duct anastomosis (DD, n = 141),...
The gut microbiota is a contributing factor in obesity-related metabolic disorders. effect of metformin on the has been reported; however, relationship between and mechanism action elderly individuals unclear. In this study, was investigated aged obese mice. abundance genera Akkermansia, Bacteroides, Butyricimonas, Parabacteroides significantly increased by mice fed high-fat diet. Metformin treatment decreased expression IL-1β IL-6 epididymal fat, which correlated with various bacterial...
Abstract BACKGROUND: The objectives of this study were to determine the proportions major oncogenic alterations and examine survival in genotype‐specific subsets never‐smokers with nonsmall cell lung cancer (NSCLC). METHODS: authors concurrently analyzed mutations epidermal growth factor receptor ( EGFR ) v‐Ki‐ ras 2 Kirsten rat sarcoma viral oncogene homolog KRAS genes investigated anaplastic lymphoma kinase ALK gene rearrangements samples from 229 NSCLC. identified by fluorescent situ...
The enhancement of the electrical conductivity by doping is important in hematite (α-Fe(2)O(3)) photoanodes for efficient solar water oxidation. However, spite many successful demonstrations using extrinsic dopants, such as Sn, Ti, and Si, achieved photocurrent still lower than practical requirement. There lack our understanding how intrinsic oxygen defects can change interact with dopants. In this study, we systematically investigate interplay vacancies Sn dopants context photoanodic...
Objective: Tamoxifen is currently used for the treatment of estrogen receptor-positive breast cancer patients, but acquired resistance to tamoxifen a critical problem in therapy.Suberoylanilide hydroxamic acid (SAHA) prototype newly developed HDAC inhibitor.The aim this study investigate anticancer effects SAHA tamoxifen-resistant MCF-7 (TAMR/MCF-7) cells.Methods: Cytotoxicity, apoptosis and autophagic cell death induced by were studied.A TAMR/MCF-7 cells xenograft model was established...
Abstract Background Vaccine‐associated anaphylaxis is a rare but life‐threatening reaction that occurs within minutes to hours of exposure allergens. As studies utilizing large‐scale data investigate this topic are limited, further research needed assess its burden, long‐term trends, and associated risk factors so as gain comprehensive understanding vaccine‐associated globally. Therefore, study aimed the global burden related vaccines. Method This utilized World Health Organization...
Emerging evidence supports artificial intelligence-enhanced electrocardiogram (AI-ECG) for detecting acute myocardial infarction (AMI), but real-world validation is needed. The aim of this study was to evaluate the performance AI-ECG in AMI emergency department (ED). Rule-Out Myocardial Infarction using Artificial intelligence Electrocardiogram analysis (ROMIAE) a prospective cohort conducted Republic Korea from March 2022 October 2023, involving 18 university-level teaching hospitals. Adult...
Objective The aims of this study were to assess the confounding effects hepatic iron deposition, inflammation, and fibrosis on steatosis (HS) evaluation by magnetic resonance imaging (MRI) spectroscopy (MRS) accuracies MRI MRS for HS evaluation, using histology as reference standard. Materials Methods In institutional review board–approved prospective study, 56 patients gave informed consents underwent chemical-shift liver a 1.5-T scanner. To estimate fat fraction (FF), 4 analysis methods...
To develop a system for texture-based quantification of emphysema on high-resolution computed tomography (HRCT) and to compare it with density-based in correlation pulmonary function test (PFT).Two hundred sixty-one circular regions interest (ROI) 16-pixel diameter [66 ROIs representing typical area normal lung; 69 bronchiolitis obliterans (BO); 64, mild (ME); 62, severe (SE)] were used train the automated classification based Support Vector Machine classifier variable texture shape...
To investigate the potential role of microRNA (miRNA) in regulation circadian rhythm, we performed microarray-based expression profiling study both miRNA and mRNA mouse liver for 48 h at 4-hour intervals. Circadian miRNA-mRNA target pair is defined as elements which show patterns sequence-based relationship can be predicted. initiators, Clock Bmal1, showed inversely correlated against their corresponding miRNAs, miR-181d miR-191, targeting them. In contrast, suppressors, Per, Cry, CKIe...
The acquisition of tamoxifen resistance is a major therapeutic problem in breast cancer. We developed tamoxifen-resistant MCF-7 (TRM-7) cell line to elucidate the molecular mechanisms and factors associated with such resistance. showed that phosphorylation STAT3 at tyrosine 705 (Y705) RANTES expression are increased response human cancer cells. On basis these results, we hypothesize upregulated may be correlated development drug Here, contribute maintenance constitutively retained via...
The effect of consumption two probiotic strains, Lactobacillus curvatus HY7601 and plantarum KY1032, on weight loss, body adiposity lipoprotein-associated phospholipase A2 (Lp-PLA2) activities in overweight subjects was examined. After 12-week treatment, the group presented reductions (−0.65 ± 0.23 kg), fat percentage (−0.57 0.19%) mass (−616 161 g) measured using DEXA, L1 subcutaneous area (−2.68 1.31 cm2) CT, compared to baseline. exhibited greater oxidized low density lipoprotein (ox-LDL)...
Long-term storage of viable mammalian cells is important for applications ranging from in vitro fertilization to cell therapy. Cryopreservation currently the most common approach, but liquid nitrogen relatively costly and requirement low temperatures during shipping inconvenient. Desiccation an alternative strategy with potential enable preservation at more convenient without need nitrogen. To achieve stability dried state it necessary remove enough water that remaining matrix forms a...