A5101730979- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Biomedical Text Mining and Ontologies
- Electronic Health Records Systems
- Cancer Genomics and Diagnostics
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Pharmacovigilance and Adverse Drug Reactions
- Semantic Web and Ontologies
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Mobile Health and mHealth Applications
- Cardiac Imaging and Diagnostics
- Pharmaceutical Practices and Patient Outcomes
- Computational Drug Discovery Methods
- Thyroid Cancer Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Gene Regulatory Network Analysis
- Pharmacy and Medical Practices
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
Seoul National University
2015-2024
Chonnam National University Hospital
2010-2024
Chonnam National University
2009-2024
Charles R. Drew University of Medicine and Science
2024
Seoul National University Hospital
2013-2024
New Generation University College
1997-2024
The University of Texas Health Science Center at Houston
2023
Seoul National University of Science and Technology
2022
Eulji University
2020-2021
Eulji University Hospital
2020-2021
A large collection of new modENCODE and ENCODE genome-wide chromatin data sets from cell lines developmental stages in worm, fly human are analysed; this reveals many conserved features organization among the three organisms, as well notable differences composition locations repressive chromatin. This study describes numerous Homo sapiens, Drosophila melanogaster Caenorhabditis elegans generated by consortia. The results point to while identifying Genome function is dynamically regulated...
Real-world evidence (RWE) and randomized control trial (RCT) data are considered mutually complementary. However, compared with RCT, the outcomes of RWE continue to be assigned lower credibility. It must emphasized that research is a real-world practice does not need executed as RCT for it reliable. The advantages disadvantages discerned clearly, then proper protocol can planned from beginning secure many samples possible. Attention paid privacy protection. Moreover, bias reduced...
Scrub typhus is caused by the obligate intracellular rickettsia Orientia tsutsugamushi (previously called Rickettsia tsutsugamushi). The bacterium maternally inherited in trombicuid mites and transmitted to humans feeding larvae. We report here 2,127,051-bp genome of Boryong strain, which represents most highly repeated bacterial sequenced date. repeat density scrub pathogen 200-fold higher than that its close relative prowazekii, agent epidemic typhus. A total 359 tra genes for components...
It has been reported that human mesenchymal stem cells (MSCs) can transfer mitochondria to the with severely compromised mitochondrial function. We tested whether intercellular could be replicated in different types of or under experimental conditions, and tried elucidate possible mechanism. Using biochemical selection methods, we found exponentially growing restrictive media (uridine(-) bromodeoxyuridine [BrdU](+)) during coculture MSCs (uridine-independent BrdU-sensitive) 143B-derived...
Abstract Purpose: The poor prognosis of hepatocellular carcinoma (HCC) is, in part, due to the high rate recurrence even after “curative resection” tumors. Therefore, it is axiomatic that development an effective prognostic prediction model for HCC surgery would, at minimum, help identify advance those who would most benefit from treatment, and best, provide new therapeutic strategies patients with a risk early recurrence. Experimental Design: For time HCC, gene expression profiles were...
Abstract Colposcopy is widely used to detect cervical cancers, but experienced physicians who are needed for an accurate diagnosis lacking in developing countries. Artificial intelligence (AI) has been recently computer-aided showing remarkable promise. In this study, we developed and validated deep learning models automatically classify neoplasms on colposcopic photographs. Pre-trained convolutional neural networks were fine-tuned two grading systems: the intraepithelial neoplasia (CIN)...
Abstract The prevalence and clinical characteristics of depressive disorders differ between women men; however, the genetic contribution to sex differences in has not been elucidated. To evaluate sex-specific architecture depression, whole exome sequencing samples from 1000 patients (70.7% female) with disorder was conducted. Control data healthy individuals no psychiatric (n = 72, 26.4% East-Asian subpopulation Genome Project 207, 50.7% were included. variation men directly compared using...
Lymphovascular invasion (LVI) is one of the most important prognostic factors in gastric cancer as it indicates a higher likelihood lymph node metastasis and poorer overall outcome for patient. Despite its importance, detection LVI(+) histopathology specimens can be challenging task pathologists subtle difficult to discern. Herein, we propose deep learning-based method using H&E-stained whole-slide images. The ConViT model showed best performance terms both AUROC AURPC among...
To investigate the potential role of microRNA (miRNA) in regulation circadian rhythm, we performed microarray-based expression profiling study both miRNA and mRNA mouse liver for 48 h at 4-hour intervals. Circadian miRNA-mRNA target pair is defined as elements which show patterns sequence-based relationship can be predicted. initiators, Clock Bmal1, showed inversely correlated against their corresponding miRNAs, miR-181d miR-191, targeting them. In contrast, suppressors, Per, Cry, CKIe...
Cellular senescence involves a reduction in adult stem cell self-renewal, and epigenetic regulation of gene expression is one the main underlying mechanisms. Here, we observed that cellular human umbilical cord blood-derived multipotent cells (hUCB-MSCs) caused by inhibition histone deacetylase (HDAC) activity leads to down-regulation high mobility group A2 (HMGA2) and, on contrary, up-regulation p16(INK)⁴(A), p21(CIP)¹(/WAF)¹ p27(KIP)¹. We found let-7a1, let-7d, let-7f1, miR-23a, miR-26a...
Abstract Objective Cancer can involve gene dysregulation via multiple mechanisms, so no single level of genomic data fully elucidates tumor behavior due to the presence numerous variations within or between levels in a biological system. We have previously proposed graph-based integration approach that combines multi-omics including copy number alteration, methylation, miRNA, and expression for predicting clinical outcome cancer. However, features likely interact with other complex signaling...
Background and Objectives. Chronic obstructive pulmonary disease (COPD) is a complex characterized by airflow limitation. Although airway inflammation oxidative stress are known to be important in the pathogenesis of COPD, mechanism underlying obstruction not fully understood. Gene expression profiling lung tissue was performed define molecular pathways that dysregulated COPD. Methods. RNA isolated from tissues obtained 98 subjects with COPD 91 control normal spirometry. The samples were...
Glutathione peroxidase 3 (GPx3), a major scavenger of reactive oxygen species (ROS) in plasma, acts as redox signal modulator. However, the mechanism underlying GPx3-mediated suppression cancer cell growth is unclear. The aim this study was to identify these mechanisms with respect lung cancer. To enhance modulating properties GPx3, cells were subjected serum starvation for 12 h, resulting ROS generation absence oxidant treatment. We then investigated whether tumorigenesis under conditions...
Article Abstract Objective: Depression is common after acute coronary syndrome (ACS) and has adverse effects on prognosis. There are few evidence-based interventions for treating depression in ACS. This study investigated the efficacy safety of escitalopram depressive disorders identified 2-14 weeks a confirmed ACS episode. Method: A total 217 patients with DSM-IV (121 major 96 minor) were randomly assigned to receive flexible doses 5-20 mg/d (n = 108) or placebo 109) 24 weeks. The was...
Abstract For cells to exit from pluripotency and commit a lineage, the circuitry of core transcription factor (CTF) network must be extinguished in an orderly manner through epigenetic modifications. However, how this choreographed remodeling at active embryonic stem cell (ESC) genes occurs during differentiation is poorly understood. In study, we demonstrate that C-terminal binding protein 2 (Ctbp2) regulates nucleosome deacetylation (NuRD)-mediated H3K27 facilitates recruitment polycomb...
Clinical studies can be conducted to gather real world evidence (RWE) not available from randomized controlled trials, providing new information and knowledge.Although the concept of RWE emerged relatively recently, numerous clinical are utilizing it.However, many researchers engaging in trial error that may overcome various biases occur electronic medical record (EMR)-based studies.While reflect world, there still limitations its acceptance.There hurdles using solutions must...
The presence of metastatic lymph nodes is a prognostic indicator for patients with thyroid carcinomas and an important determinant clinical decision making. However, evaluating neck requires experience labor- time-intensive. Therefore, the development computer-aided diagnosis (CAD) system to identify differentiate may be useful.From January 2008 December 2016, we retrieved records 804 consecutive 812 nodes. status all was confirmed by fine-needle aspiration. datasets were split into training...
Classification of colorectal neoplasms during colonoscopic examination is important to avoid unnecessary endoscopic biopsy or resection. This study aimed develop and validate deep learning models that automatically classify lesions histologically on white-light colonoscopy images.
Abstract Purpose: Gastric cancer is heterogeneous clinically and histologically, prognosis prediction by tumor grade or type difficult. Although previous studies have suggested that frozen tissue–based molecular classifications effectively predict prognosis, prognostic classification on formalin-fixed tissue needed, especially in early gastric cancer. Experimental Design: We immunostained 659 consecutive cancers using 56 tumor-associated antibodies the array method. Hierarchical cluster...
The aim of this study was to investigate the effects paeoniflorin (PF) and paeonol (PN), main active compounds Paeonia albiflora Pallas, on myocardial ischemia reperfusion (I/R)-induced injury in Sprague-Dawley rats vivo. Under anesthesia, were subjected 25 min by ligation left anterior descending coronary artery (LAD) followed 6 h (Western blot analysis) or 24 (hemodynamics infarct size) reperfusion. When size measured as percentage area at risk, both PF (25.0 % ± 7.0 %) PN (24.1 5.5...
Abstract Background Previous differential coexpression analyses focused on identification of differentially coexpressed gene pairs, revealing many insightful biological hypotheses. However, this method could not detect relationships between pairs sets. Considering the success set-wise analysis methods for microarray data, a based sets may elucidate underlying processes provoked by conditional changes. Here, we propose (dCoxS) algorithm that identifies set conditions. Results dCoxS is...