A5079777837- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal Tumor Research and Treatment
- Renal and related cancers
- Wnt/β-catenin signaling in development and cancer
- Sarcoma Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Diet and metabolism studies
- Urinary Tract Infections Management
- Gut microbiota and health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Neonatal and fetal brain pathology
- Digital Imaging for Blood Diseases
- Pharmacological Receptor Mechanisms and Effects
Chonnam National University Hwasun Hospital
2017-2025
Ajou University
2024
Chonnam National University Hospital
2015-2024
Chonnam National University
2016-2023
Weatherford College
2021-2023
University of Washington
2023
Gwangju Institute of Science and Technology
2019-2022
Korea Disease Control and Prevention Agency
2021
National Health Insurance Service
2021
Lymphovascular invasion (LVI) is one of the most important prognostic factors in gastric cancer as it indicates a higher likelihood lymph node metastasis and poorer overall outcome for patient. Despite its importance, detection LVI(+) histopathology specimens can be challenging task pathologists subtle difficult to discern. Herein, we propose deep learning-based method using H&E-stained whole-slide images. The ConViT model showed best performance terms both AUROC AURPC among...
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types cancer, and novel treatment regimens are direly needed. Epigenetic regulation contributes to development various cancer types, but its role in potential as a therapeutic target for PDAC underexplored. Here, we show that PRMT1 is highly expressed murine human pancreatic essential cell proliferation tumorigenesis. Deletion delays KRAS-dependent mouse model, multi-omics analyses reveal depletion leads global changes...
Epithelial-mesenchymal transition (EMT), principally involving an E-cadherin to N-cadherin shift, linked tumor invasion or metastasis, and therapeutic resistance in various human cancer. A growing body of recent evidence has supported the hypothesis that EMT play a crucial role invasive phenotype gliomas. To evaluate prognostic connotation traits glioma, expression was explored large series glioma patients relation patient survival rate.Expressions E- were examined using immunohistochemical...
Abstract Background Comparisons of the gut microbiome lean and obese humans have revealed that obesity is associated with plus changes in numerous environmental factors, including high-fat diet (HFD). Here, we report two species Bifidobacterium are crucial to controlling metabolic parameters Korean population. Results Based on microbial analysis from 99 individuals, observed abundance longum bifidum was markedly reduced individuals increased visceral adipose tissue (VAT), body mass index...
Abstract Diffuse large B‐cell lymphoma (DLBCL) is a heterogeneous and prevalent subtype of aggressive non‐Hodgkin that poses diagnostic prognostic challenges, particularly in predicting drug responsiveness. In this study, we used digital pathology deep learning to predict responses immunochemotherapy patients with DLBCL. We retrospectively collected 251 slide images from 216 DLBCL treated rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R‐CHOP), their response labels. The...
Traditional serrated adenoma (TSA) is a rare and precancerous lesion of colorectal cancer. The clinical endoscopic differentiations between TSAs without dysplasia or adenocarcinoma (TSAOs) with (TSADs) remain unclear. To evaluate the characteristics compare TSAOs those TSADs. This retrospective study included 193 patients who underwent resection received pathologic diagnosis TSA. We reviewed medical, endoscopic, histopathologic records January 2010 December 2023. were more frequently located...
Spondin-2 (SPON2) is involved in cancer progression and metastasis of many tumors; however, its role underlying mechanism gastric are still obscure. In this study, we investigated the SPON2 related signaling pathway metastasis. expression levels were found to be upregulated cell lines patient tissues compared normal epithelial cells controls. Furthermore, silencing was observed decrease proliferation motility reduce tumor growth xenograft mice. Conversely, overexpression increase motility....
Aims: This study assessed the expression and clinical relevance of cancer-asssociated fibroblast (CAF)-related biomarkers in brain metastasis (BM). Moreover, molecular characterization patient-derived primary CAFs normal fibroblasts (NFs) was performed. Methods: Sixty-eight patients with BM from various cancer types were selected. Immunohistochemistry (IHC) immunofluorescence (IF) staining performed to evaluate CAF-related biomarkers. NFs isolated fresh tissues. Results: Various expressed...
The identification of predictive biomarkers or models is necessary for the selection patients who might benefit most from immunotherapy. Seven histological features (signet ring cell [SRC], fibrous stroma, myxoid tumor-infiltrating lymphocytes [TILs], necrosis, tertiary lymphoid follicles, and ulceration) detected in surgically resected tissues (N = 44) were used to train a model. presence SRC became an optimal decision parameter pathology alone (AUC 0.78). Analysis differentially expressed...
The oncoprotein KAI1 C-terminal interacting tetraspanin (KITENIN; vang-like 1) promotes cell metastasis, invasion, and angiogenesis, resulting in shorter survival times cancer patients. Here, we aimed to determine the effects of KITENIN on energy metabolism human colorectal cells.The were evaluated using vitro assays. GEPIA web tool was used extrapolate clinical relevance metabolism. bioavailability effect disintegrator complex compounds by LC-MS, vivo animal assay.KITENIN markedly...
Abstract The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, administration Lactobacillus spp. ameliorates diet-induced obesity humans mice. However, mechanisms through which control host remain unclear. Accordingly, this study, we evaluated physiological fermentum controlling obesity. Our results demonstrated that L. fermentum- potentiated oxidative phosphorylation adipose tissue, resulting increased energy expenditure to...
Breast cancer (BC) is the second most common solid malignant tumor that metastasizes to brain. Despite emerging therapies such as immunotherapy, whether microenvironment (TME) in breast brain metastasis (BCBM) has potential a target of new treatments unclear. Expression profiling 770 genes 12 pairs primary BC and matched (BM) samples was performed using NanoString nCounter PanCancer IO360TM Panel. Immune cell profiles were validated by immunohistochemistry (IHC) from 50 patients with BCBM....
The receptor tyrosine kinase, recepteur d'origine nantais (RON), is known to be associated with the progression, metastasis, and prognosis of various types cancers. Nevertheless, role RON in human oral squamous cell carcinoma (OSCC) unclear. This study evaluated whether affects oncogenic behavior, signaling pathways, clinical outcomes, including survival, OSCC. Reverse transcription‑PCR, quantitative PCR, western blotting immunohistochemical staining were used determine mRNA protein...
Abstract Background Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses metastases. Herein, we investigated relationship between expression stromal CAF markers metastatic sites, platelet-derived growth factor receptor-beta (PDGFR-β), alpha-smooth muscle actin (α-SMA) prognostic variables BCBM patients. Methods Immunohistochemistry (IHC) PDGFR-β α-SMA...
Yes-associated protein (YAP) in the Hippo signaling pathway is a growth control that regulates cell proliferation and stem functions. Abnormal regulation of YAP was reported human cancers including liver, lung, breast, skin, colon, ovarian cancer. However, function not known prostate adenocarcinoma. The purpose this study to investigate role tumorigenesis, differentiation, prognosis adenocarcinoma.The nuclear cytoplasmic expression examined 188 cases adenocarcinoma using...
Several studies reported that aspirin can potentially help prevent infection and serious complications of coronavirus disease (COVID-19), but no study has elucidated a definitive association between COVID-19. This aims to investigate the COVID-19.This case-control used demographic, clinical, health screening laboratory test data collected from National Health Insurance Service database. Patients who tested positive for severe acute respiratory syndrome 2 (SARS-CoV-2) until June 4, 2020, were...
The molecular profile of cholangiocarcinoma (CC) remains elusive. prognostic value isocitrate dehydrogenase (IDH) mutations in CC is controversial, and there have been few relevant studies Asian populations. In the present study, we investigated frequency significance IDH Korean patients with CC. specimens were collected from who underwent surgical liver resection between 2004 2019. Clinical pathological data retrospectively reviewed medical records. Mutational profiling was performed by...
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a mesenchymal tumor originating from various soft tissues and meninges, which carries the NAB2-STAT6 fusion gene. Meningeal/intracranial SFT/HPCs (icSFT/HPC) have poor clinical outcome with metastatic behavior compared to tissue/extracranial (exSFT/HPC), but underlying genetic factors are unclear. Differentially expressed genes (DEGs) were analyzed by NanoString nCounter assay using RNA extracted formalin-fixed paraffin-embedded (FFPE)...
This is the first reported case of pineal lymphoma with concomitant prolactin-producing pituitary adenoma.A 51-year-old male experienced worsening headaches accompanied by nausea, diplopia, and memory loss for 1 month. Cranial nerve examination revealed bilateral upward gaze limitation convergence impairment, which known as Parinaud syndrome. Magnetic resonance images a mass in gland coexisting within enlarged sella fossa. Hormone analysis hyperprolactinemia. The was removed without injuring...
Background: Stroke involving the cerebral white matter (WM) has increased in prevalence, but most experimental studies have focused on ischemic injury of gray matter.This study was performed to investigate WM a unique rat model photothrombotic infarct targeting posterior limb internal capsule (PLIC), focusing identification vulnerable structure by injury, subsequent glial reaction and fundamental histopathologic feature causing different neurologic outcomes.Methods: Light microscopy with...
Urinary bladder cancer has various etiologies and tends to recur then progress a higher grade. When muscles are invaded, the response conventional therapy is poor quality of life deteriorates rapidly. Here, we summarize compare two representative methods used create syngeneic mouse models required for immunological research.In this study, utilized six-week-old female C3H/HeNCrl mice tumor cell line MBT-2. The first method involved transurethral catheterization with poly-L-lysine pretreatment...
Abstract The skin supports a diverse microbiome whose imbalance is related to inflammation and diseases. Exposure fine particulate matter (PM 2.5 ), major air pollutant, can adversely affect the microbiota equilibrium. In this study, effect mechanism of PM exposure in HaCaT keratinocytes were investigated. stimulated aryl hydrocarbon receptor (AhR) produce reactive oxygen species (ROS) cells, leading mitochondrial dysfunction intrinsic apoptosis. We observed that culture medium derived from...
Tumor-to-tumor metastasis with schwannoma as a recipient tumor is very rare. There have been no reports on to spinal metastasis. We report case of 57-year-old woman who presented neck pain and turned out cervical nerve breast carcinoma