A5026872254- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Metastasis and carcinoma case studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Liver Disease and Transplantation
- Diverticular Disease and Complications
- Ubiquitin and proteasome pathways
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Pancreatitis Pathology and Treatment
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
Chonnam National University
2016-2025
Chonnam National University Hospital
2009-2024
Chonnam National University Hwasun Hospital
2013-2023
Weatherford College
2021
Dongguk University Ilsan Hospital
2016
Seoul National University
2016
Yonsei University
2016
Gangnam Severance Hospital
2016
Hallym University Sacred Heart Hospital
2016
Wonkwang University
2016
Abstract Background The aim of this study was to evaluate the time trend seropositivity Helicobacter pylori ( H . ) over period 13 years in an asymptomatic Korean population, and investigate associated risk factors. Methods This cross-sectional nationwide multicentre surveyed anti- IgG antibodies 19,272 health check-up subjects (aged [greater than equal to]16 years) 2011. Risk factors for infection were investigated using logistic regression. Seropositivity without eradication compared...
<b>Background and study aims:</b> Post-polypectomy coagulation syndrome (PPCS) is a well known complication of colonoscopic polypectomy. However, no previous studies have reported on the clinical outcomes or risk factors PPCS. The aim current was to analyze PPCS developing after <b>Patients methods:</b> Data for all patients who underwent polypectomies required hospitalization in nine university hospitals were analyzed retrospectively. incidence, clinicopathological characteristics, cases...
Atrophic gastritis (AG) and intestinal metaplasia (IM) are premalignant gastric lesions. The aims of this study were to evaluate the prevalence endoscopic AG IM document risk factors for these lesions.In total, 4,023 subjects enrolled at eight hospitals in Korea. diagnosed by endoscopy. Helicobacter pylori immunoglobulin G antibodies measured.The prevalences 40.7% 12.5%. In a multivariate analysis, age groups 40 59 years >60 years, male sex, positive H. serology, IM, education below college...
Helicobacter pylori eradication rates with clarithromycin-based triple therapy are declining, and an alternative strategy is needed urgently. We sought to compare the efficacy of pretreatment antimicrobial susceptibility-guided vs. for H. in a region high multiple drug resistance.Consecutive pylori-infected patients gastric epithelial neoplasms were randomized receive or 7 days. In whom infection was not eradicated, antibiotics given according initial susceptibility test as second-line both...
Cell invasion is a crucial mechanism of cancer metastasis and malignancy. Matrix metalloproteinase-9 (MMP-9) an important proteolytic enzyme involved in the cell process. High expression levels MMP-9 gastric positively correlate with tumor aggressiveness have significant negative correlation patients' survival times. Recently, mechanisms suppressing by phytochemicals become increasingly investigated. Chrysin, naturally occurring chemical plants, has been reported to suppress metastasis....
Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social economic burden worldwide. The aim this study to identify prevalence risk factors in health check-up population tertiary centers Korea.A nationwide multicenter prospective was performed at 9 healthcare Korea between September 2016 June 2017. A total 2525 subjects were investigated based on endoscopic findings questionnaires with Rome III criteria, Helicobacter pylori serology (IgG).A 1714...
Immunotherapy has revolutionized the clinical outcomes of intractable cancer patients. Little is known about intestinal nonpathogenic bacterial composition hepatocellular carcinoma (HCC) patients treated by immunotherapy.To determine whether there a correlation between gut and prognosis in HCC patients.From September 2019 to March 2020, we prospectively collected fecal samples examined microbiome 8 advanced with nivolumab as second- or third-line systemic treatment. Fecal were before start...
Dieulafoy lesion is a rare cause of massive gastrointestinal hemorrhage, most commonly from the proximal stomach. Surgery was regarded as treatment choice in past, but recently endoscopic management has become standard approach. However, effectiveness various modalities treating bleeding been little studied. This study therefore done to compare hemostatic efficacy hemoclipping and epinephrine injection therapy.Between January 1998 December 2001, consecutive series 32 patients with underwent...
Mast cells (MC) may be one factor influencing the response of visceral afferent nerves to mechanical and chemical stimuli. The aim this study was evaluate degree infiltration activity colonic MC in irritable bowel syndrome (IBS). Biopsy specimens were obtained from cecum rectum 14 diarrhea predominant IBS normal controls. Electron microscopy used determine number intact degranulated quantify these separately according distance between enteric nerves. An increased both group comparison with...
Dieulafoy's lesion is a rare cause of massive gastrointestinal hemorrhage, most commonly in the proximal stomach. Mechanical endoscopic methods have recently become standard therapeutic approach. However, there been few studies comparing efficacy different mechanical treating gastric lesions. This study was therefore carried out to compare hemostatic and safety band ligation (EBL) hemoclip placement (EHP) treatment bleeding lesions.Between January 2002 October 2003, 26 consecutive patients...
Capsaicin is known to have tumor suppressive effects. However, the molecular mechanisms and targets of capsaicin involved in exerting anticancer activity are complex remain be clarified. The aim current study was investigate effects on human gastric cancer cells (AGS cells) demonstrate that induced apoptosis AGS cells. Results MTT assay flow cytometry revealed potentially inhibited proliferation vitro a dose-dependent manner. Cleaved caspase-3 increased Bcl-2 reduced by treatment with...
Objective This study was conducted to present the clinical outcome of invasive fungal sinusitis sphenoid sinus and analyze factors influencing patient survival. Methods A retrospective review 12 cases sphenoiditis conducted. Results Cases were divided into acute fulminant spheonoidits (n=4) chronic (n=8). The most common underlying disease diabetes mellitus (n=9). presenting symptoms signs included visual disturbance (100%). Intracranial extension observed in 8 patients. Endoscopic...
Epigallocatechin-3-gallate (EGCG), the primary catechin in green tea, has anti-inflammatory and anti-oxidative properties. The aim of current study was to characterize impact EGCG on lipopolysaccharide (LPS)-induced innate signaling bone marrow-derived macrophages (BMMs) isolated from ICR mice.The effect LPS-induced pro-inflammatory gene expression nuclear factor-κB (NF-κB) mitogen-activated protein kinase (MAPK) examined using reverse transcription-polymerase chain reaction, Western...
With advances in diagnostic endoscopy, the detection of rectal neuroendocrine tumors (NETs) has increased. However, clinical outcomes, especially after endoscopic treatment, are still unclear. The aim this study was to determine long-term outcomes endoscopically resected NETs according pathologic status initial resection.In large, multicenter, retrospective cohort study, we analyzed medical records patients who underwent resection and were followed for ≥24 months at 16 university hospitals....
Angiogenesis is a key prerequisite for the successful establishment, growth, and dissemination of tumors. Vascular endothelial growth factor (VEGF) has potent angiogenic activity cyclooxygenase-2 (COX-2) promotes angiogenesis by modulated production factors including VEGF. The current study was designed to investigate possible roles COX-2 VEGF in gastric cancer angiogenesis. In this study, we conducted an immunohistochemical investigation expression 97 patients with cancer. To assess tumor...
Bacterial infection may be a critical trigger for variceal bleeding. Antibiotic prophylaxis can prevent rebleeding in patients with acute gastroesophageal bleeding (GEVB). The aim of the study was to compare prophylactic third generation cephalosporins on-demand antibiotics prevention rebleeding. In prospective trial, first GEVB were randomly assigned receive (intravenous cefotaxime 2 g q 8 hr 7 days, group) or same only when became evident (on-demand group). Sixty-two group and 58 included...
<h3>Background and aims</h3> 90K, a tumour-associated glycoprotein, interacts with galectins has roles in host defence by augmenting the immune response, but serum 90K level was suggested to indicate poor prognosis several cancers. The cellular mechanisms of action on colorectal cancer (CRC) cell motility its effect CRC progression were investigated. <h3>Methods</h3> impact analysed combining cultures, vitro assays, immunohistochemistry. <h3>Results</h3> Secreted suppresses invasion, this is...
Background The impact of tomato lycopene extract (TLE) on intestinal inflammation is currently unknown. We investigated the effect TLE lipopolysaccharide (LPS)-induced innate signaling and experimental colitis. Methodology/Principal Findings Mice were fed a diet containing 0.5 2% or isoflavone free control (AIN-76). therapeutic efficacy was assessed using dextran sulfate sodium (DSS) exposed mice IL-10−/−;NF-κBEGFP mice, representing an acute spontaneous chronic colitis model respectively. A...