A5040340052- Ubiquitin and proteasome pathways
- Psychosocial Factors Impacting Youth
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- Education and Learning Interventions
- Cell Adhesion Molecules Research
- Lichen and fungal ecology
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Click Chemistry and Applications
- Bone Metabolism and Diseases
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Global Educational Reforms and Inequalities
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Bryophyte Studies and Records
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Advanced Breast Cancer Therapies
Chonnam National University
2014-2024
Chonnam National University Hwasun Hospital
2010-2024
Bank of Korea
2017-2020
Chonnam National University Hospital
2005-2018
Korea University
2013
CHA University
2010
CHA Bundang Medical Center
2010
Chosun University
2000-2009
University of Arkansas for Medical Sciences
2009
Korea Basic Science Institute
2009
A number of distinct stress signaling pathways in myocardium cause cardiac hypertrophy and heart failure. Class II histone deacetylases (HDACs) antagonize several stress-induced hypertrophy. However, induced by transgenic overexpression the homeodomain only protein, HOP, can be prevented nonspecific HDAC inhibitors trichostatin valproic acid, suggesting that alternate targets oppose class function might exist myocardium. We tested effects inhibitors, including a I HDAC-selective inhibitor,...
Osteoclast differentiation from hematopoietic precursors is controlled by the tumor necrosis factor family member factor-related activation-induced cytokine (TRANCE) via induction of various transcription factors, including nuclear activated T cells (NFAT) c1. During osteoclast differentiation, NFATc1 further calcium signaling when costimulatory receptors expressed on precursors, such as osteoclast-associated receptor (OSCAR), are stimulated. Here we show that expression precedes OSCAR...
Diverse cardiac diseases induce hypertrophy, which leads to dilatation and heart failure. We previously reported that hypertrophy can be blocked by class I histone deacetylase (HDAC) inhibitor, prompted us investigate the regulatory mechanism of HDACs. Cardiac was introduced aortic banding, infusion isoproterenol or angiotensin II, swimming. Hypertrophic stimuli transiently elevated activity deacetylase-2 (Hdac2), a HDAC. In cardiomyocytes, forced expression Hdac2 simulated in an...
Lichens are symbiotic organisms which produce distinct secondary metabolic products. In the present study, we tested cytotoxic activity of 17 lichen species against several human cancer cells and further investigated molecular mechanisms underlying their anti-cancer activity. We found that among lichens species, F. cucullata exhibited most potent cytotoxicity in cells. High performance liquid chromatography analysis revealed acetone extract contains usnic acid, salazinic Squamatic...
Epithelial-mesenchymal transition (EMT), principally involving an E-cadherin to N-cadherin shift, linked tumor invasion or metastasis, and therapeutic resistance in various human cancer. A growing body of recent evidence has supported the hypothesis that EMT play a crucial role invasive phenotype gliomas. To evaluate prognostic connotation traits glioma, expression was explored large series glioma patients relation patient survival rate.Expressions E- were examined using immunohistochemical...
Cell invasion is a crucial mechanism of cancer metastasis and malignancy. Matrix metalloproteinase-9 (MMP-9) an important proteolytic enzyme involved in the cell process. High expression levels MMP-9 gastric positively correlate with tumor aggressiveness have significant negative correlation patients' survival times. Recently, mechanisms suppressing by phytochemicals become increasingly investigated. Chrysin, naturally occurring chemical plants, has been reported to suppress metastasis....
Abstract Lichens are symbiotic organisms that produce various secondary metabolites. Here, different lichen extracts were examined to identify metabolites with anti-migratory activity against human lung cancer cells. Everniastrum vexans had the most potent inhibitory activity, and atranorin was identified as an active subcomponent of this extract. Atranorin suppressed β-catenin-mediated TOPFLASH by inhibiting nuclear import β-catenin downregulating β-catenin/LEF c-jun/AP-1 downstream target...
Thymosin beta(10) is a monomeric actin sequestering protein that regulates dynamics. Previously, we and others have shown thymosin acts as an actin-mediated tumor suppressor. In this study, show not only cytoskeletal regulator, but it also potent inhibitor of angiogenesis growth by its interaction with Ras. We found overexpressed significantly inhibited vascular endothelial factor-induced cell proliferation, migration, invasion, tube formation in vitro. Vessel sprouting was ex vivo. further...
Abstract We cloned recently an alternatively spliced variant of KAI1 mRNA that lacked exon 7 at the COOH-terminal region and showed differences in metastasis suppression when compared with wild-type KAI1. These findings indicated is critical for its suppressor function. In this study, we isolated a cDNA clone VANGL1, member tetraspanin protein family, which interacted specifically cytoplasmic domain yeast two-hybrid system. renamed it interacting (KITENIN). found KITENIN-overexpressing CT-26...
Lichens are symbiotic organisms that produce various unique chemicals can be used for pharmaceutical purposes. With the aim of screening new anti-cancer agents inhibit cancer cell motility, we tested inhibitory activity seven lichen species collected from Romanian Carpathian Mountains against migration and invasion human lung cells further investigated molecular mechanisms underlying their anti-metastatic activity. Among them, Alectoria samentosa, Flavocetraria nivalis, ochroleuca, Usnea...
Both nitric oxide (NO) and natriuretic peptides produce apoptosis of vascular smooth muscle cells. However, there is evidence that NO induces endothelial cell proliferation, which suggests a difference in the response cells to peptides. The purpose this study was investigate effect atrial peptide (ANP) on human survival. ANP within physiological concentration (10 −11 mol/l) induced 52% increase number coronary arterial 63% umbilical vein at low serum. numbers blocked by pretreatment with...
The transcription of neuron-specific genes must be repressed in nonneuronal cells. REST/NRSF is a factor that restricts the expression many neuronal through interaction with neuron-restrictive silencer element at promoter level. PAHX-AP1 gene developmentally up-regulated adult mouse brain but has no functional NRSE motif its 5' upstream sequence. Here, we report AP4 and corepressor geminin form complex which SMRT histone deacetylase 3 are recruited. represses cells participates regulating...
Object The authors evaluated the clinical manifestations and surgical results in patients with cystic vestibular schwannoma (VS), investigated matrix metalloproteinase (MMP) expression of cyst fluid wall an attempt to elucidate pathogenesis characteristics this disease. Methods neuroimaging features, perioperative findings, outcomes 24 cases VS 82 solid VS, all which were treated using suboccipital approach, retrospectively compared. To evaluate role MMP gelatin zymography...
Homeodomain only protein, Hop, is an unusual small protein that modulates target gene transcription without direct binding to DNA. Here we show Hop interacts with Enhancer of Polycomb1 (Epc1), a homolog Drosophila polycomb group product regulates transcription, induce the skeletal muscle differentiation. Yeast two-hybrid assay human adult heart cDNA library revealed can associate Epc1. The amino-terminal domain Epc1 as well full physically interacted in mammalian cells and yeast. highly...