A5086377751- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Cardiovascular Health and Disease Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
Chonnam National University Hospital
2016-2025
Chonnam National University
2015-2024
Ministry of Health and Welfare
2012-2024
Pohang University of Science and Technology
2024
Chonnam National University Hwasun Hospital
2021-2023
Weatherford College
2020-2022
Yonsei University
2022
Ulsan University Hospital
2021
Thrombolysis in Myocardial Infarction Study Group
2021
Therapeutics Clinical Research
2019
Mesenchymal stem cells (MSCs) have been widely studied for their applications in cell-based regeneration. During myocardial infarction (MI), infiltrated macrophages pivotal roles inflammation, angiogenesis and cardiac remodeling. We hypothesized that MSCs may modulate the immunologic environment to accelerate This study was designed assess functional relationship between macrophage phenotype MSCs. isolated from bone marrow marrow-derived (BMDMs) underwent differentiation induced by...
A number of distinct stress signaling pathways in myocardium cause cardiac hypertrophy and heart failure. Class II histone deacetylases (HDACs) antagonize several stress-induced hypertrophy. However, induced by transgenic overexpression the homeodomain only protein, HOP, can be prevented nonspecific HDAC inhibitors trichostatin valproic acid, suggesting that alternate targets oppose class function might exist myocardium. We tested effects inhibitors, including a I HDAC-selective inhibitor,...
Background: Procedural results for percutaneous coronary intervention (PCI) in vessels with chronic total occlusion (CTO) have improved recent years, and PCI strategies moved toward more complete revascularization liberal use of CTO-PCI. However, evidence evaluating CTO-PCI is limited to observational studies small clinical trials. Methods: In this open-label, multicenter, randomized, noninferiority trial, PCI-eligible patients were assigned receive either 1 2 strategies: or no the...
Abstract Ischaemic heart disease (IHD) is the leading cause of death worldwide. Although myocardial cell plays a significant role in infarction (MI), its underlying mechanism remains to be elucidated. To understand progression MI and identify potential therapeutic targets, we performed tandem mass tag (TMT)-based quantitative proteomic analysis using an mouse model. Gene ontology (GO) gene set enrichment (GSEA) revealed that glutathione metabolic pathway reactive oxygen species (ROS) were...
Development of localized inflammatory environments by M1 macrophages in the cardiac infarction region exacerbates heart failure after myocardial (MI). Therefore, regulation inflammation and their timely polarization toward regenerative M2 suggest an immunotherapy. Particularly, controlling cellular generation reactive oxygen species (ROS), which cause differentiation, developing macrophage phenotypes propose a therapeutic approach. Previously, stem or dendritic cells were used MI for...
Background:The Korea Acute Myocardial Infarction Registry (KAMIR)-National Institutes of Health (NIH) registry has the aim evaluating clinical characteristics, management, and long-term outcomes patients with acute myocardial infarction (AMI) in Korea.Methods Results:Patients hospitalized for AMI 20 tertiary university hospitals have been enrolled since November 2011. The study is expected to complete scheduled enrollment approximately 13,000 October 2015, follow-up duration up 5 years each...
<h3>Importance</h3> Depression has been associated with poorer medical outcomes in acute coronary syndrome (ACS), but there are few data on the effects of antidepressant treatment long-term prognosis. <h3>Objective</h3> To investigate effect major adverse cardiac events (MACE) escitalopram depression patients recent ACS. <h3>Design, Setting, and Participants</h3> Randomized, double-blind, placebo-controlled trial conducted among 300 ACS enrolled from May 2007 to March 2013, follow-up...
Although venoarterial extracorporeal membrane oxygenation (VA-ECMO) is beneficial for the treatment of profound cardiogenic shock, peripheral VA-ECMO cannulation can increase left ventricular afterload, thus compromising myocardial recovery. We investigated whether early routine unloading reduce 30-day mortality compared with conventional approach in patients shock undergoing VA-ECMO.
Myocardial infarction (MI) is a major cause of death worldwide. After the occurrence MI, heart frequently undergoes serious pathological remodeling, leading to excessive dilation, electrical disconnection between cardiac cells, and fatal functional damage. Hence, extensive efforts have been made suppress remodeling promote repair infarcted heart. In this study, we developed hydrogel patch that can provide mechanical support, conduction, tissue adhesiveness aid in recovery an function....
A comprehensive nationwide study on the incidence and outcomes of COVID-19 vaccination-related myocarditis (VRM) is in need.Among 44 276 704 individuals with at least 1 dose vaccination, clinical courses VRM cases confirmed by Expert Adjudication Committee Korea Disease Control Prevention Agency were analyzed. was 480 (1.08 per 100 000 persons). Vaccination-related significantly higher men than women (1.35 vs. 0.82 persons, P < 0.001) mRNA vaccines other (1.46 0.14 0.001). highest males...
Female mice are much more resistant to ischemia/reperfusion (I/R)-induced kidney injury when compared with males. Although estrogen administration can partially reduce associated I/R, we demonstrated that the presence of testosterone, than absence estrogen, plays a critical role in gender differences susceptibility ischemic injury. Testosterone females increases ischemia. Dihydrotestosterone, which not be aromatized has effects equal those testosterone. Castration reduces I/R-induced In...
Heart failure is associated with death of cardiomyocytes leading to loss contractility. Previous studies using membrane-targeted Akt (myristolated-Akt), an enzyme involved in antiapoptotic signaling, showed inhibition cell and prevention pathogenesis induced by cardiomyopathic stimuli. However, recent our group have found accumulation activated the nucleus, suggesting that biologically relevant target(s) activity may be located there. To test this hypothesis, a targeted construct was created...
We investigated the mechanism by which cannabinoid receptors-1 (CB1) and -2 (CB2) modulate inflammatory activities of macrophages. Real-time polymerase chain reaction showed predominant CB2 expression in freshly isolated human monocytes. PMA, a potent inducer differentiation, upregulated CB1 increased CB1:CB2 transcript ratio from 1:17.5 to 1:3 5 days culture. Immunohistochemistry that protein was colocalized CD68- CD36-positive macrophages atheroma. Through selective or...
This study was designed to examine whether mesenchymal stem cells (MSCs) transduced with Akt enhance cardiac repair after transplantation into the ischemic porcine heart.MSCs isolated from bone marrow and myr-Akt were transplanted hearts experimental myocardial infarction (MI) using intracoronary injection [Group I, vehicle; Group II, MSCs; III, Akt-MSCs]. Myocardial single photon emission tomography (M-SPECT) performed assess function infarcted area. Pigs also sacrificed for...
Background Myocardial infarction with nonobstructive coronary arteries ( MINOCA ) is a heterogeneous disease entity. Its prognosis and predictor of mortality remain unclear. This study aimed to compare the between myocardial obstructive artery identify factors related all-cause death in using nation-wide, multicenter, prospective registry. Methods Results Among 13 104 consecutive patients enrolled, without previous history significant who underwent angiography were selected. The primary...
Stem cell therapy has emerged as a potential modality for myocardial infarction treatment. Mesenchymal stem cells (MSCs) exert reparative actions in the injured myocardium mainly through secretion of paracrine factors. In addition, overexpression connexin 43 (Cx43), gap junction protein, promotes cardiac repair and function restoration. It is known that MSCs spheroid form, which have enhanced cell–cell interaction, exhibit expression factors Cx43. However, cell‐extracellular matrix (ECM)...
Abstract Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases. However, the molecular mechanisms linking VC to these diseases have yet be elucidated. Here we report that MDM2-induced ubiquitination of histone deacetylase 1 (HDAC1) mediates VC. Loss HDAC1 activity via either chemical inhibitor or genetic ablation enhances protein, but not mRNA, reduced in cell animal models human calcified coronary artery. Under calcification-inducing conditions,...