A5025802408- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Health and Disease Prevention
- Tissue Engineering and Regenerative Medicine
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Angiogenesis and VEGF in Cancer
- Hormonal Regulation and Hypertension
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Congenital heart defects research
- Potassium and Related Disorders
- Mechanical Circulatory Support Devices
- Venous Thromboembolism Diagnosis and Management
- Eicosanoids and Hypertension Pharmacology
Catholic University of Korea
2015-2024
Seoul St. Mary's Hospital
2015-2024
Seoul Medical Center
2024
Yonsei University
2020
Severance Hospital
2020
Chungbuk National University Hospital
2019
Hallym University Sacred Heart Hospital
2019
Soonchunhyang University Hospital
2019
Janssen (United States)
2016
Deleted Institution
2016
Abstract— LCZ696 (Japanese adopted name: sucabitril valsartan sodium hydrate), a first-in-class angiotensin receptor neprilysin inhibitor, concomitantly inhibits and blocks type 1 receptor. This randomized, double-blind, placebo-controlled study, the first in Asia for this drug, evaluated dose-related efficacy safety of patients with hypertension using 24-hour ambulatory blood pressure (BP) monitoring. Asian aged ≥18 years (n=389) were randomized to receive 100 mg (n=100), 200 (n=101), 400...
Background and Objectives:The burden of heart failure has increased in Korea.This registry aims to evaluate demographics, clinical characteristics, management, long-term outcomes patients hospitalized for acute (AHF).Subjects Methods: We prospectively enrolled a total 5625 consecutive subjects AHF one 10 tertiary university hospitals from March 2011 February 2014.Descriptive statistics were used determine the baseline characteristics study population compare them with those other...
Aims This study aimed to develop and validate deep-learning-based artificial intelligence algorithm for predicting mortality of AHF (DAHF). Methods results 12,654 dataset from 2165 patients with in two hospitals were used as train data DAHF development, 4759 10 enrolled the Korean registry performance test data. The endpoints in-hospital, 12-month, 36-month mortality. We compared Get Guidelines–Heart Failure (GWTG-HF) score, Meta-Analysis Global Group Chronic Heart (MAGGIC) other...
The application of a simple blood test to predict prognosis in acute heart failure (AHF) patients is not well established. Neutrophil-lymphocyte ratio (NLR) inexpensive and easy obtain hospitalized using routine test. We evaluate the prognostic implications NLR as an independent predictor in-hospital long-term mortality AHF patients. Among 5625 enrolled Korean Acute Heart Failure registry, 5580 were classified into quartiles by their level, analyzed for post-discharge three-year mortality....
Background Many patients with heart failure ( HF ) reduced ejection fraction r EF experience improvement or recovery of left ventricular LVEF ). Data on clinical characteristics, outcomes, and medical therapy in improved (HFiEF) are scarce. Methods Results Of 5625 consecutive hospitalized for acute the KorAHF (Registry [Prospective Cohort] Heart Failure Korea) study, 5103 had baseline echocardiography 2302 follow-up at 12 months. phenotypes were defined as persistent ≤40% 1-year follow-up),...
Reactive oxygen species (ROS) and intracellular iron levels are critical modulators of lipid peroxidation that trigger iron-dependent non-apoptotic ferroptosis in myocardial ischemia-reperfusion (I/R) injury. Histochrome (HC), with a potent antioxidant moiety iron-chelating capacity, is now available clinical practice. However, limited data about the protective effects HC on ferroptotic cell death I/R In this study, we investigated whether intravenous administration (1 mg/kg) prior to...
Background In clinical practice, a risk prediction model is an effective solitary program to predict prognosis in particular patient groups. B-type natriuretic peptide (BNP)and N-terminal pro-b-type (NT-proBNP) are widely recognized outcome-predicting factors for patients with heart failure (HF).This study derived external validation of score 1-year mortality after discharge hospitalized HF using the Meta-analysis Global Group Chronic Heart Failure (MAGGIC)program data. We also assessed...
Cardiovascular diseases (CVDs) are a major cause of death worldwide. Due to the prevalence many side effects and incomplete recovery from pharmacotherapies, stem cell therapy is being targeted for treatment CVDs. Among different types cells, endothelial progenitor cells (EPCs) have great potential. However, cellular replicative senescence decreases proliferation, migration, overall function EPCs. Sirtuin 1 (SIRT1) has been mainly studied in mammalian aging process. MHY2233 potent synthetic...
Objective There are conflicting results among previous studies regarding the prognosis of heart failure with preserved ejection fraction (HFpEF) compared reduced (HFrEF). This study aimed to compare outcomes patients de novo acute (AHF) or decompensated HF (ADHF) according HFpEF (EF≥50%), HFrEF (EF<40%) and define mid-range EF (HFmrEF, 40≤EF<50%). Methods Between March 2011 February 2014, 5625 consecutive AHF were recruited from 10 university hospitals. A total 5414 (96.2%) data...
Guideline-directed medical therapy (GDMT) with renin-angiotensin system (RAS) inhibitors and beta-blockers has improved survival in patients heart failure reduced ejection fraction (HFrEF). As clinical trials usually do not include very old patients, it is unknown whether the results from are applicable to elderly HF. This study was performed investigate characteristics treatment strategies for HFrEF a large prospective cohort.The Korean Acute Heart Failure (KorAHF) registry consecutively...
The clinical characteristics and outcomes of acute heart failure (AHF) according to left ventricular ejection fraction (LVEF) have not been fully elucidated, especially for patients with mid-range LVEF. We performed a comprehensive comparison the epidemiology, patterns in-hospital management, in AHF different LVEF categories.
To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving active ingredients. However, safety evaluation is crucial during development stage before commercialization. Therefore, aim this study was to evaluate cytotoxicity two types newly nanoemulsions. Turmeric extract-loaded powder-10.6 (TE-NEP-10.6, high content artificial surfactant Tween 80), which forms optimal nanoemulsion, and TE-NEP-8.6 made by increasing...