A5060322031- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Transplantation: Methods and Outcomes
- Cardiovascular and exercise physiology
- Cardiovascular Health and Disease Prevention
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Nutrition and Health in Aging
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Cardiomyopathy and Myosin Studies
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Potassium and Related Disorders
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Mechanical Circulatory Support Devices
- Cardiac Health and Mental Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
Severance Hospital
2016-2025
Yonsei University
2016-2025
Gangnam Severance Hospital
2015-2024
National Heart Centre Singapore
2024
British Heart Foundation
2024
National Heart Hospital
2024
Cardiovascular Institute Hospital
2012-2024
The University of Texas Rio Grande Valley
2023-2024
Seoul National University Bundang Hospital
2013-2024
SUNY Downstate Health Sciences University
2024
The pathogenic role of T cells in hypertension has been documented well recent animal studies. However, the existence T-cell–driven inflammation human not confirmed. Therefore, we undertook immunologic characterization from patients with and measured circulating levels C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for cells. We analyzed markers on by multicolor flow cytometry. then monokine induced γ interferon (IFN), IFN γ–induced protein 10,...
BackgroundCoronary artery calcium (CAC) score is a clinically validated marker of cardiovascular disease risk. We developed and novel risk stratification system based on deep-learning-predicted CAC from retinal photographs.MethodsWe used 216 152 photographs five datasets South Korea, Singapore, the UK to train validate algorithms. First, using one dataset Korean health-screening centre, we trained deep-learning algorithm predict probability presence (ie, score, RetiCAC). stratified RetiCAC...
BackgroundSteroidal mineralocorticoid receptor antagonists reduce morbidity and mortality among patients with heart failure reduced ejection fraction, but their efficacy in those mildly or preserved fraction has not been established. Data regarding the safety of nonsteroidal antagonist finerenone are needed.MethodsIn this international, double-blind trial, we randomly assigned a left ventricular 40% greater, 1:1 ratio, to receive (at maximum dose 20 mg 40 once daily) matching placebo,...
Aims To describe the baseline characteristics of participants in FINEARTS‐HF trial, contextualized with prior trials including patients heart failure (HF) mildly reduced and preserved ejection fraction (HFmrEF/HFpEF). The trial is comparing effects non‐steroidal mineralocorticoid receptor antagonist finerenone placebo reducing cardiovascular death total worsening HF events HFmrEF/HFpEF. Methods results Patients symptomatic HF, left ventricular (LVEF) ≥40%, estimated glomerular filtration...
The number of people with heart failure (HF) is increasing worldwide, and the social burden as HF has high mortality morbidity. We aimed to provide updated trends on epidemiology in Korea shape future measures against HF.
Background and Objectives:The burden of heart failure has increased in Korea.This registry aims to evaluate demographics, clinical characteristics, management, long-term outcomes patients hospitalized for acute (AHF).Subjects Methods: We prospectively enrolled a total 5625 consecutive subjects AHF one 10 tertiary university hospitals from March 2011 February 2014.Descriptive statistics were used determine the baseline characteristics study population compare them with those other...
Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is biomarker of poor outcome in ischemic heart disease. However, its precise role postischemic cardiovascular remodeling poorly understood. Here, we show Angpt2 plays multifaceted roles the exacerbation cardiac hypoxia and inflammation after myocardial ischemia. was highly expressed endothelial cells at infarct border zone infarction (MI) or ischemia/reperfusion injury mice. In acute...
<h3>Objective</h3> Plasma level of N-terminal–pro-brain natriuretic peptide (NT-proBNP) is a reliable prognostic factor in patients with heart failure (HF). However, it unclear how differently the biomarker predicts adverse outcomes HF preserved EF (HFpEF) versus reduced (HFrEF). <h3>Methods</h3> From Korean Heart Failure registry, prospective multicentre cohort for consecutive who were hospitalised acute syndrome, those available NT-proBNP and LVEF measurements extracted. Patients ≥50%...
Aims This study aimed to develop and validate deep-learning-based artificial intelligence algorithm for predicting mortality of AHF (DAHF). Methods results 12,654 dataset from 2165 patients with in two hospitals were used as train data DAHF development, 4759 10 enrolled the Korean registry performance test data. The endpoints in-hospital, 12-month, 36-month mortality. We compared Get Guidelines–Heart Failure (GWTG-HF) score, Meta-Analysis Global Group Chronic Heart (MAGGIC) other...
The application of a simple blood test to predict prognosis in acute heart failure (AHF) patients is not well established. Neutrophil-lymphocyte ratio (NLR) inexpensive and easy obtain hospitalized using routine test. We evaluate the prognostic implications NLR as an independent predictor in-hospital long-term mortality AHF patients. Among 5625 enrolled Korean Acute Heart Failure registry, 5580 were classified into quartiles by their level, analyzed for post-discharge three-year mortality....
Calcium (Ca2+) signaling is an important process, implicated in cancer cell proliferation and motility of the deadly glioblastomas that aggressively invade neighboring brain tissue. We have previously demonstrated caffeine blocks glioblastoma invasion extends survival by inhibiting Ca2+ release channel inositol 1,4,5-trisphosphate receptor (IP3R) subtype 3. Trifluoperazine (TFP) FDA-approved antipsychotic drug for schizophrenia. Interestingly, TFP has been recently reported to show a strong...
Background Many patients with heart failure ( HF ) reduced ejection fraction r EF experience improvement or recovery of left ventricular LVEF ). Data on clinical characteristics, outcomes, and medical therapy in improved (HFiEF) are scarce. Methods Results Of 5625 consecutive hospitalized for acute the KorAHF (Registry [Prospective Cohort] Heart Failure Korea) study, 5103 had baseline echocardiography 2302 follow-up at 12 months. phenotypes were defined as persistent ≤40% 1-year follow-up),...
Background and Objectives: Heart failure (HF) is a disease with high morbidity mortality.With ageing society increasing prevalence of risk factors HF, the HF expected to increase, as well.In this official report Korean Society Failure epidemiology in Korea presented.Methods: The data National Health Insurance big data, (KorHF) Acute (KorAHF) registries have been used.Results: In 2018, prevalence, incidence, mortality patients, due were 2,261, 579, 245, 10.4 per 100.000persons,...
Abstract Aims Sacubitril/valsartan (SV) reduced heart failure hospitalization and cardiovascular mortality compared with enalapril in the Prospective Comparison of ARNI ACE‐I to Determine Impact on Global Mortality Morbidity Heart Failure trial. However, this trial excluded patients end stage renal disease (ESRD); thus, efficacy safety SV ejection fraction (HFrEF) ESRD remains uncertain. Methods results We retrospectively analysed clinical laboratory data 501 HFrEF who administered from...
Importance Atrial fibrillation (AF) can develop following thoracic irradiation. However, the critical cardiac substructure responsible for AF has not been properly studied. Objective To describe incidence of in patients with lung cancer and determine predictive dosimetric parameters. Design, Setting, Participants This retrospective cohort study was performed at a single referral center included 239 diagnosed limited-stage small cell (SCLC) 321 locally advanced non–small (NSCLC) between...
BACKGROUND: The morbidity and mortality rates of patients with heart failure (HF) functional mitral regurgitation (MR) remain substantial despite guideline-directed medical therapy for HF. We evaluated the efficacy ertugliflozin reduction MR associated HF mild to moderately reduced ejection fraction. METHODS: EFFORT trial (Ertugliflozin Functional Mitral Regurgitation) was a multicenter, double-blind, randomized examine hypothesis that sodium-glucose cotransporter 2 inhibitor is effective...
Bone marrow mesenchymal stem cells (MSCs) have shown potential for cardiac repair following myocardial injury, but this approach is limited by their poor viability after transplantation. To reduce cell loss transplantation, we introduced the fibroblast growth factor-2 (FGF-2) gene ex vivo before The isolated MSCs produced colonies with a fibroblast-like morphology in 2 weeks; over 95% expressed CD71, and 28% cardiomyocyte-specific transcription factor, Nkx2.5, as well α-skeletal actin,...
Acute heart failure (AHF) is associated with a poor prognosis and it requires repeated hospitalizations. However, there are few studies on the characteristics, treatment prognostic factors of AHF. The aims this study were to describe clinical management outcomes patients hospitalized for AHF in Korea.We analyzed data 3,200 hospitalization episodes that recorded between June 2004 April 2009 from Korean Heart Failure (KorHF) Registry database. mean age was 67.6±14.3 years 50%...