A5021564348- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Blood Pressure and Hypertension Studies
- Peripheral Artery Disease Management
- Cardiovascular Disease and Adiposity
- Chemotherapy-induced cardiotoxicity and mitigation
- Atherosclerosis and Cardiovascular Diseases
- Optical Imaging and Spectroscopy Techniques
- Vascular Procedures and Complications
- Acute Myocardial Infarction Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Angiogenesis and VEGF in Cancer
- Hormonal Regulation and Hypertension
- Infectious Aortic and Vascular Conditions
- Cardiac electrophysiology and arrhythmias
- Entrepreneurship Studies and Influences
- Lipoproteins and Cardiovascular Health
- RNA Interference and Gene Delivery
- Cardiac Arrhythmias and Treatments
- Paraoxonase enzyme and polymorphisms
- Tissue Engineering and Regenerative Medicine
- Renal and Vascular Pathologies
- Advanced MRI Techniques and Applications
Ewha Womans University
2013-2025
Yonsei University
2000-2022
Baewha Women's University
2003-2022
Severance Hospital
2004-2022
Korea Institute of Ceramic Engineering and Technology
2022
Kyungpook National University
2022
Korea University Medical Center
2022
Hanyang University
2022
Hanmi Pharmaceutical (South Korea)
2022
Korea Institute of Machinery and Materials
2019
For healthy populations without comorbidities, whether prehypertension and impaired fasting glucose (IFG) are associated with new onset atrial fibrillation (AF) is not well known. We included 366 507 subjects (age ≥20 years) diagnosed non-valvular AF from the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC) 2003 to 2008. In total, 139 306 AF-related comorbidities were excluded, a 227 102 population was followed up until 2013. The body mass index (BMI), blood...
Bone marrow mesenchymal stem cells (MSCs) have shown potential for cardiac repair following myocardial injury, but this approach is limited by their poor viability after transplantation. To reduce cell loss transplantation, we introduced the fibroblast growth factor-2 (FGF-2) gene ex vivo before The isolated MSCs produced colonies with a fibroblast-like morphology in 2 weeks; over 95% expressed CD71, and 28% cardiomyocyte-specific transcription factor, Nkx2.5, as well α-skeletal actin,...
Abstract Urothelial bladder carcinoma (UBC) is characterized by a large number of genetic alterations. DNA from urine promising source for liquid biopsy in urological malignancies. We aimed to assess the availability cell-free (cfDNA) and exosomal (exoDNA) as UBC. included 9 patients who underwent surgery UBC performed genomic profiling tumor samples matched urinary cfDNA exoDNA. For mutation analysis, deep sequencing was gene targets shallow whole genome (sWGS) used detection copy variation...
The precipitation behavior and mechanical properties of high-nitrogen austenitic stainless steels were investigated for various chemical compositions solution treatment temperatures. For this study, Fe-22.1Cr-12.2Ni-5.1Mn-2.1Mo alloys with three different sets Nb, V, N contents prepared, two distinct temperatures applied. An increase in Nb or content resulted finer austenite grain size, attributed to the formation additional precipitates, such as Z-phase (Nb,V)(C,N), at boundaries. Notably,...
Lysyl-tRNA synthetase 1 (KARS1), an aminoacyl-tRNA synthetase, was recently identified as a secreted pro-inflammatory agent. However, the vascular secretion and functions of KARS1 have not been characterized. This study investigated mechanisms explored its functional roles in biology. We found that expression upregulated by oscillatory shear stress, atherogenic factor, suggesting presence free dissociated from complexes. Moreover, Ca2+, serum starvation triggered cytosolic release...
Traditional touch trigger probes are widely used on most commercial coordinate measuring machines (CMMs). However, the CMMs with these have a systematic error due to shape of probe tip and elastic deformation stylus resulting from contact pressure specimen. In this paper, new three degrees-of-freedom force sensor is proposed. From relationships between an obtained vector geometric probe, it possible calculate coordinates exact probe–specimen points. An empirical model applied points amount...
Accurate measurement of peripheral tissue perfusion is challenging but necessary to diagnose vascular insufficiency. Because near infrared (NIR) radiation can penetrate relatively deep into tissue, significant attention has been given intravital NIR fluorescence imaging.We developed a new optical imaging-based strategy for quantitative by time-series analysis local pharmacokinetics the fluorophore, indocyanine green (ICG). Time-series images were obtained after injecting ICG intravenously in...
Introduction The presence of late gadolinium enhancement (LGE) at the right ventricular insertion point (RVIP) on cardiac magnetic resonance (CMR) is generally believed to be nonspecific, but clinical implication this unique LGE pattern in patients with non-ischemic dilated cardiomyopathy (NICM) has not been elucidated. Objectives We investigated prognostic significance RVIP-LGE NICM patients. Methods A total 360 consecutive referred for CMR (102 no LGE, 50 RVIP-LGE, 121 left [LV]-LGE, and...
Soluble receptor for advanced glycation end products RAGE (sRAGE), a secretory form of RAGE, plays an important role in suppressing signals that induce pro-inflammatory gene activation range inflammatory diseases, such as Alzheimer's disease, complications diabetes mellitus and atherosclerosis. Recent studies have suggested fluid shear stress generated by laminar blood flow protects vessels from atherosclerosis, whereas low oscillatory (OSS) disturbed causes Although levels are increased...
Diabetes mellitus (DM) is one of the most common diseases worldwide. Uncontrolled and prolonged hyperglycemia can cause diabetic complications, which reduce quality life patients. Diabetic complications are in DM Because it impossible to completely recover from important for early detection. In this study, we suggest a novel method determining blood flow characteristics based on fluorescence image analysis with indocyanine green report that have unique characteristics.We analyzed time-series...
Vascular endothelial growth factor receptor-2 (VEGFR2) plays a key role in maintaining vascular homeostasis. Here, we show that blood flows determine activation and inactivation of VEGFR2 through selective cysteine modifications. is regulated by reversible oxidation at Cys1206 residue. H2O2-mediated induced oscillatory flow cells the induction NADPH oxidase-4 expression. In contrast, laminar induces expression nitric oxide synthase results S-nitrosylation Cys1206, which counteracts oxidative...
Abstract Extracellular vesicles (EVs) have emerged as a potential delivery vehicle for nucleic‐acid‐based therapeutics, but challenges related to their large‐scale production and cargo‐loading efficiency limited therapeutic potential. To address these issues, we developed novel “shock wave extracellular engineering technology” (SWEET) non‐genetic, scalable manufacturing strategy that uses shock waves (SWs) encapsulate siRNAs in EVs. Here, describe the use of SWEET platform load large...
Abstract Atherosclerosis occurs preferentially in arterial regions exposed to disturbed blood flow. Targeting these pro-atherogenic is a potential anti-atherogenic therapeutic approach, but it has been extremely challenging. Here, using vivo phage display approach and the partial carotid ligation model of flow-induced atherosclerosis mouse, we identified novel peptides that specifically bind endothelial cells (ECs) flow condition regions. Two peptides, CLIRRTSIC CPRRSHPIC, selectively bound...
The properties of Al-doped SnOx films deposited via reactive co-sputtering were examined in terms their potential applications for the fabrication transparent and flexible electronic devices. Al 2.2-atom %-doped thin-film transistors (TFTs) exhibit improved semiconductor characteristics compared to non-doped films, with a lower sub-threshold swing ~0.68 Vdec−1, increased on/off current ratio ~8 × 107, threshold voltage (Vth) near 0 V, markedly reduced (by 81%) Vth instability air,...
Background: There are still controversies about long‐term clinical outcomes of sirolimus‐eluting stents (SES) versus bare metal (BMS) implantation in patients with end‐stage renal diseases (ESRD). Objective: To compare (ESRD) following SES BMS implantation. Methods: Between March 2003 and July 2005, a total 54 (80 lesions) ESRD undergoing [SES‐ESRD] were enrolled compared 51 (54 receiving during the same periods [BMS‐ESRD] Korean Multicenter Angioplasty Team Registry. The primary outcome was...
Abstract: This study was conducted to investigate the sensory characteristics and consumer acceptability of beef stock samples containing GSH‐xylose Maillard reaction product (GX) and/or monosodium glutamate (MSG) with varying levels salt (NaCl). The were examined using a descriptive analysis. Total 50 consumers evaluated overall flavor intensities odor, salty taste, flavor, seasoning in samples. Samples both GX MSG (GX‐MSG), only (GX), higher level (GX‐NaCl) had stronger “beef...
Purpose:To report successful percutaneous repair of a peripheral mycotic aneurysm as bridge to standard surgical therapy.Case Report:An the left common femoral artery was diagnosed in 43-year-old man with subacute infective endocarditis. A Jostent stent-graft percutaneously deployed exclude lesion. Computed tomography at 8 months after procedure documented regression and patency without evidence infection. Arteriography 18 has confirmed continued patient remains asymptomatic.Conclusions:The...
Advanced atherosclerosis is often associated with dystrophic calcification and remodeling of extracellular matrix vascular wall. Recently many studies have documented a general relationship between severity coronary disease, discussed the feasibility electron beam computed tomography for detecting quantifying artery in patients. The present study investigated expression localization osteopontin, one noncollagenous bone protein, within calcified arteries. Autopsy-derived specimens were...