A5100429324- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- Cancer-related Molecular Pathways
- Education and Learning Interventions
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Consumer Perception and Purchasing Behavior
- NF-κB Signaling Pathways
- Nonlinear Partial Differential Equations
- Plant chemical constituents analysis
- Bioactive Compounds and Antitumor Agents
- Advanced Mathematical Modeling in Engineering
- interferon and immune responses
- Cell death mechanisms and regulation
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Conducting polymers and applications
- Telecommunications and Broadcasting Technologies
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Diverse Approaches in Healthcare and Education Studies
- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
Kyung Hee University
2015-2025
Yonsei University
2016-2025
Electronics and Telecommunications Research Institute
2014-2025
Samsung (South Korea)
2012-2025
Ulsan College
2000-2025
Soonchunhyang University Hospital
2000-2025
National Cancer Center
2002-2025
University of Ulsan
2007-2025
Asan Medical Center
2000-2025
Dong-Eui University
2021-2025
Abstract mTORC1 is an important regulator of muscle mass but how it modulated by oxygen and nutrients not completely understood. We show that loss the prolyl hydroxylase domain isoform 1 sensor in mice (PHD1 KO ) reduces mass. PHD1 muscles impaired activation response to leucine whereas growth factors or eccentric contractions was preserved. The ability promote activity independent its hydroxylation caused decreased protein content leucyl tRNA synthetase (LRS) sensor. Mechanistically,...
The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide unified interface biomedical databases that are distributed worldwide. portal provides access numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the independently administered funded their host data federation...
Knowledge regarding the genetic risk loci for gestational diabetes mellitus (GDM) is still limited. In this study, we performed a two-stage genome-wide association analysis in Korean women. stage 1 genome scan, 468 women with GDM and 1,242 nondiabetic control were compared using 2.19 million genotyped or imputed markers. We selected 11 further genotyping 2 samples of 931 case 783 subjects. The joint effect plus studies was analyzed by meta-analysis. also investigated known type variants GDM....
In this study, we found that alpha-pinene (α-pinene) exhibits anti-inflammatory activity through the suppression of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) pathway in mouse peritoneal macrophages. α-Pinene is oils many coniferous trees rosemary. We investigated inhibitory effects on inflammatory responses induced by lipopolysaccharide (LPS) using significantly decreased LPS-induced production interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), nitric...
Frequent discrepancies between preclinical and clinical results of anticancer agents demand a reliable translational platform that can precisely recapitulate the biology human cancers. Another critical unmet need is ability to predict therapeutic responses for individual patients. Toward this goal, we have established library orthotopic glioblastoma (GBM) xenograft models using surgical samples GBM These patient-specific tumors histopathological properties maintain genomic characteristics...
Abstract β-Amyloid precursor protein (APP) and its cleaved products are strongly implicated in Alzheimer’s disease (AD). Endosomes highly active APP processing sites, endosome anomalies associated with upregulated expression of early endosomal regulator, rab5, the earliest known disease-specific neuronal response AD. Here, we show that rab5 effector APPL1 (adaptor containing pleckstrin homology domain, phosphotyrosine binding domain leucine zipper motif) mediates overactivation Down syndrome...
Commensal bacteria are critically involved in the establishment of tolerance against inflammatory challenges, molecular mechanisms which just being uncovered. All kingdoms life produce aminoacyl-tRNA synthetases (ARSs). Thus far, non-translational roles ARSs have largely been reported eukaryotes. Here, we report that threonyl-tRNA synthetase (AmTARS) gut-associated bacterium Akkermansia muciniphila is secreted and functions to monitor modulate immune homeostasis. Secreted AmTARS triggers M2...
Abstract Amyloid-β (Aβ) oligomers are implicated in the onset of Alzheimer’s disease (AD). Herein, quinoline-derived half-curcumin-dioxaborine (Q-OB) fluorescent probe was designed for detecting Aβ by finely tailoring hydrophobicity biannulate donor motifs donor-π-acceptor structure. Q-OB shows a great sensing potency dynamically monitoring oligomerization during amyloid fibrillogenesis vitro. In addition, we applied this strategy to fluorometrically analyze self-assembly kinetics...
Autosomal-recessive juvenile parkinsonism (AR-JP) is caused by loss-of-function mutations of the parkin gene. Parkin, a RING-type E3 ubiquitin ligase, responsible for ubiquitination and degradation substrate proteins that are important in survival dopamine neurons Parkinson's disease (PD). Accordingly, abnormal accumulation neurotoxic substrates attributable to loss function may be cause neurodegeneration parkin-related parkinsonism. We evaluated known identified date null mice determine...
The clinicopathologic characteristics of malignant lymphomas vary according to geography. aim this study was determine the clinical and relative frequency in Republic Korea belonging newly described REAL (revised European-American lymphoma) classification categories.The Hematolymphoreticular Study Group Korean Society Pathologists conducted a consensus-based morphologic review nationwide collection 1548 lymphomas, including Hodgkin's disease (HD), diagnosed at 23 institutes over recent...