A5007806208- Genomics and Chromatin Dynamics
- Asymmetric Synthesis and Catalysis
- Fluorine in Organic Chemistry
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Inorganic Fluorides and Related Compounds
- Advanced Proteomics Techniques and Applications
- Mass Spectrometry Techniques and Applications
- RNA and protein synthesis mechanisms
- Cancer Mechanisms and Therapy
- Asymmetric Hydrogenation and Catalysis
- Fungal and yeast genetics research
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Plant Reproductive Biology
- DNA Repair Mechanisms
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Ion-surface interactions and analysis
- Bioinformatics and Genomic Networks
- Chromosomal and Genetic Variations
- Viral Infectious Diseases and Gene Expression in Insects
- Porphyrin Metabolism and Disorders
- Hemoglobin structure and function
Sun Yat-sen University
2015-2024
Institute for Systems Biology
2015-2024
InSysBio (Russia)
2023-2024
European Bioinformatics Institute
2015-2024
University of South China
2009-2024
Shanghai First Maternity and Infant Hospital
2024
Fujian Normal University
2024
SIB Swiss Institute of Bioinformatics
2024
Weizmann Institute of Science
2020-2023
Jiangnan University
2022
The BioMart Community Portal (www.biomart.org) is a community-driven effort to provide unified interface biomedical databases that are distributed worldwide. portal provides access numerous database projects supported by 30 scientific organizations. It includes over 800 different biological datasets spanning genomics, proteomics, model organisms, cancer data, ontology information and more. All resources available through the independently administered funded their host data federation...
Abstract Enantioselective trifluoromethylthiolation, especially of alkenes, is a challenging task. In this work, we have developed an efficient approach for enantioselective trifluoromethylthiolating lactonization by designing indane‐based bifunctional chiral sulfide catalyst and shelf‐stable electrophilic SCF 3 reagent. The desired products were formed with diastereoselectivities >99:1 good to excellent enantioselectivities. transformation represents the first trifluoromethylthiolation...
The Saccharomyces cerevisiae kinase Bur1 is involved in coupling transcription elongation to chromatin modification, but not all important targets the complex are known. Using a chemical genetics strategy wherein was engineered be regulated by specific inhibitor, we found that phosphorylates Spt5 C-terminal repeat domain (CTD) both vivo and isolated complexes vitro. Deletion of CTD or mutation serines targeted reduces recruitment PAF complex, which functions recruit factors modification mRNA...
BioMart Central Portal is a first of its kind, community-driven effort to provide unified access dozens biological databases spanning genomics, proteomics, model organisms, cancer data, ontology information and more. Anybody can contribute an independently maintained resource the Portal, allowing it be exposed shared with research community, linking other resources in portal. Users take advantage common interface quickly utilize different sources without learning new system for each. The...
The general transcription factor IID (TFIID) is a critical component of the eukaryotic preinitiation complex (PIC) and responsible for recognizing core promoter DNA initiating PIC assembly. We used cryo-electron microscopy, chemical cross-linking mass spectrometry, biochemical reconstitution to determine complete molecular architecture TFIID define conformational landscape in process TATA box-binding protein (TBP) loading onto DNA. Our structural analysis revealed five states presence TFIIA...
New approaches for the synthesis of enantiopure trifluoromethylthiolated molecules by chiral selenide-catalyzed allylic trifluoromethylthiolation and intermolecular difunctionalization unactivated alkenes are disclosed. In these transformations, functional groups were well tolerated, desired products obtained in good yields with excellent chemo-, enantio-, diastereoselectivities. This reaction is nicely complementary to enantioselective trifluoromethylthiolation, functionalization, alkene...
Novel cinchona alkaloid-derived bifunctional organocatalysts containing sulfonamide groups were utilized to promote Michael addition of bicyclic α-substituted β-ketoesters nitroolefins. The desired adducts with all-carbon quaternary centers constructed in high yield and excellent enantioselectivity, demonstrating the great potential sulfonamides asymmetric catalysis.
Transcription activation domains (ADs) are inherently disordered proteins that often target multiple coactivator complexes, but the specificity of these interactions is not understood. Efficient transcription by yeast Gcn4 requires its tandem ADs and four activator-binding (ABDs) on target, Mediator subunit Med15. Multiple ABDs a common feature complexes. We find large Gcn4-Med15 complex heterogeneous contains nearly all possible AD-ABD interactions. forms via dynamic fuzzy protein-protein...
Trifluoromethylthiolated molecules are an important class of biologically active compounds and potential drug candidates. Because the lack efficient synthetic methods, catalytic enantioselective construction these is rare remains a challenge. To expand this field, we herein disclose bifunctional selenide-catalyzed approach for synthesis various chiral trifluoromethylthiolated tetrahydronaphthalenes bearing all-carbon quaternary stereocenter with gem-diaryl-tethered alkenes alkynes by merging...
An efficient approach to vicinal trifluoromethylthioamination of alkenes with a broad substrate scope catalyzed by electron-rich diaryl selenide has been developed. This intermolecular amination strategy was successfully applied SCF3-esterification using weak acids as nucleophiles.
Twice as good: The title reaction using the tryptophan-derived bifunctional organic catalyst 1 has been developed. reported method led to synthesis of chiral γ-substituted butenolides in excellent yields, with high diastereo- and enantioselectivities. Facile glycerol derivatives containing a tertiary hydroxy group also demonstrated. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
The enantioselective construction of axially chiral compounds by electrophilic carbothiolation alkynes is disclosed for the first time. This transformation enabled use a Ts-protected bifunctional sulfide catalyst and Ms-protected ortho-alkynylaryl amines (Ts=tosyl; Ms=mesyl). Both arylthiolating trifluoromethylthiolating reagents are suitable this reaction. obtained products vinyl-aryl amino sulfides can be easily converted into biaryl sulfides, sulfoxides, amines, other valuable...
Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member SWI/SNF remodeler family, plays critical roles in genome maintenance, transcription, and repair. Here, we report cryo-electron microscopy (cryo-EM) crosslinking mass spectrometry (CLMS) studies yeast complex show that composed rigid tripartite core two flexible lobes....
Construction of two kinds prevalent skeletons for chiral pyrrolidines bearing a quaternary stereocenter and bridged dinitrogen heterocycles is long-standing challenge in synthetic organic chemistry. In this work, we introduce multifunctional Ag(I)/CAAA-amidphos complex-catalyzed asymmetric [3 + 2] cycloaddition α-substituted acrylamides with iminoesters as powerful strategy the construction 4,4-disubstituted endoamidopyrrolidines (up to 98% yield, m/b > 99:1, 99% ee)...
Bisphenol A (BPA), one of the most abundantly produced endocrine disrupting chemicals, is widely used in everyday plastic products and thus must be monitored. Multimode sensing platforms are able to combine advantages different strategies while solving issues inaccurate test results single signal sensing. However, exploration this field limited due compromise conditions inevitable mutual interferences systems. Herein, we constructed a two-dimensional photonic crystal dually cross-linked...
Enantioselective difunctionalization of alkenes offers a straightforward means for the rapid construction enantioenriched complex molecules. Despite tremendous efforts devoted to this field, enantioselective aminative remains challenge, particularly through an electrophilic addition fashion. Herein, we report unprecedented approach via copper-catalyzed with external azo compounds as nitrogen sources. A series valuable cyclic hydrazine derivatives either [3 + 2] cycloaddition or...
Organocatalytic asymmetric Michael reactions of fluorinated nucleophiles with nitroolefins catalyzed by Cinchona alkaloid-derived thioureacatalysts generated the desired products containing vicinal quaternary and tertiary chiral centers exceptional enantioselectivity.
The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberrant complexes contribute human disease. Snf5/SMARCB1/INI1 subunit of a tumor suppressor frequently lost in pediatric rhabdoid cancers. We examined the effects Snf5 loss on composition, nucleosome binding, recruitment, activities SWI/SNF. shown by crosslinking-mass spectrometry (CX-MS) deletion analysis interact with ATPase domain Snf2 form submodule consisting Snf5, Swp82, Taf14. promotes binding...
An indane-based, bifunctional, chiral selenide catalyst has been developed. The new is efficient for the enantioselective synthesis of saturated azaheterocycles possessing a trifluoromethylthio group. desired products were obtained in good yields with high diastereo- and enantioselectivities.