Yong Liang
A5066819567- Wheat and Barley Genetics and Pathology
- Plant Disease Resistance and Genetics
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Animal Nutrition and Physiology
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Plant-Microbe Interactions and Immunity
- Genetic Mapping and Diversity in Plants and Animals
- Chromosomal and Genetic Variations
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Gene expression and cancer classification
- Genetic and phenotypic traits in livestock
- Estrogen and related hormone effects
- Plant pathogens and resistance mechanisms
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Genetics and Plant Breeding
- Ovarian cancer diagnosis and treatment
- Bacteriophages and microbial interactions
- Plant Pathogens and Resistance
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
Tel Aviv University
2023-2024
Central South University
2024
University of Electronic Science and Technology of China
2024
Zigong First People's Hospital
2016-2024
Wuyi University
2024
Xihua University
2024
Xiangya Hospital Central South University
2024
Wuyi University
2024
Ningbo University Affiliated Hospital
2023
Jianghan University
2009-2022
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion human genome was generated by whole-genome shotgun sequencing method. The 14.8-billion bp DNA over 9 months from 27,271,853 high-quality reads (5.11-fold coverage genome) both ends plasmid clones made five individuals. Two assembly strategies—a and a regional chromosome assembly—were used, each combining data Celera publicly funded effort. public were shredded into 550-bp segments to create 2.9-fold those regions...
Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes 1 deaths each year. Tenfold shotgun sequence coverage was obtained from PEST strain A. assembled into scaffolds span 278 base pairs. A total 91% genome organized in 303 scaffolds; largest scaffold 23.1 There substantial genetic variation within this strain, apparent existence two haplotypes approximately equal frequency ("dual haplotypes") fraction likely reflects outbred...
PHAge Search Tool (PHAST) is a web server designed to rapidly and accurately identify, annotate graphically display prophage sequences within bacterial genomes or plasmids. It accepts either raw DNA sequence data partially annotated GenBank formatted performs number of database comparisons as well phage 'cornerstone' feature identification steps locate, features. Relative other tools, PHAST up 40 times faster 15% more sensitive. also able process both Genbank files, provide richly tables on...
We report on the quality of a whole-genome assembly Drosophila melanogaster and nature computer algorithms that accomplished it. Three independent external data sources essentially agree with support assembly's sequence ordering contigs across euchromatic portion genome. In addition, there are isolated we believe represent nonrepetitive pockets within heterochromatin centromeres. Comparison previously sequenced 2.9- megabase region indicates sequencing accuracy segments is greater than 99....
The International Cancer Genome Consortium (ICGC) is a collaborative effort to characterize genomic abnormalities in 50 different cancer types. To make this data available, the ICGC has created Data Portal. Powered by BioMart software, Portal allows each member institution manage and maintain its own databases locally, while seamlessly presenting all single access point for users. currently contains from 24 projects, including ICGC, Atlas (TCGA), Johns Hopkins University, Tumor Sequencing...
A combination of advanced sequencing and mapping techniques is used to produce a reference genome Aegilops tauschii, progenitor the wheat D genome, providing valuable resource for comparative genetic studies. Sequencing genomes crops plants provides useful resources crop improvement breeding. Jan Dvořák, Katrien Devos, Steven Salzberg colleagues report diploid hexaploid wheat. They use ordered-clone sequencing, whole-genome shotgun BioNano optical assemble this large highly repetitive...
Minsheng You and colleagues report the whole-genome sequence of diamondback moth, Plutella xylostella. Their transcriptome analysis from different life stages, together with comparative genomic phylogenetic analysis, provides insights into herbivore evolution insect adaptation to plant feeding detoxification. How an evolves become a successful is profound biological practical importance. Herbivores are often adapted feed on specific group evolutionarily biochemically related host plants1,...
BioMart Central Portal is a first of its kind, community-driven effort to provide unified access dozens biological databases spanning genomics, proteomics, model organisms, cancer data, ontology information and more. Anybody can contribute an independently maintained resource the Portal, allowing it be exposed shared with research community, linking other resources in portal. Users take advantage common interface quickly utilize different sources without learning new system for each. The...
High-density genetic linkage maps are necessary for precisely mapping quantitative trait loci (QTLs) controlling grain shape and size in wheat. By applying the Infinium iSelect 9K SNP assay, we have constructed a high-density map with 269 F 8 recombinant inbred lines (RILs) developed between Chinese cornerstone wheat breeding parental line Yanda1817 high-yielding Beinong6. The contains 2431 SNPs 128 SSR & EST-SSR markers total coverage of 3213.2 cM an average interval 1.26 per marker....
Verticillium dahliae isolates are most virulent on the host from which they were originally isolated. Mechanisms underlying these dominant adaptations currently unknown. We sequenced genome of V. Vd991, is highly its original host, cotton, and performed comparisons with reference genomes JR2 (from tomato) VdLs.17 lettuce). Pathogenicity-related factor prediction, orthology multigene family classification, transcriptome analyses, phylogenetic pathogenicity experiments performed. The Vd991...
Stripe rust and powdery mildew are both devastating diseases for durum common wheat. Pyramiding of genes conferring resistance to one or more in a single cultivar is an important breeding approach provide broader spectra resistances wheat improvement. A new gene originating from wild emmer (Triticum turgidum var. dicoccoides) backcrossed into (T. aestivum) line WE35 was identified. It conferred intermediate level Blumeria graminis f. sp. tritici isolate E09 at the seedling stage high adult...
Human tumors harbor a plethora of microbiota. It has been shown that the composition and diversity intratumor microbiome are significantly associated with survival patients pancreatic ductal adenocarcinoma (PDAC). However, association in Chinese as well effect different microorganisms on inhibiting tumor growth unclear. In this study, we collected samples resected from long-term short-term PDAC survivors performed 16S rRNA amplicon sequencing. We found time were different, differential...
Chicken prolactin (PRL) is a physiological candidate gene for egg production. The objective of the current research was to investigate association polymorphisms in chicken PRL promoter region with Genotyping 177 individuals from White Leghorn, Yangshan, Taihe Silkies, Rock, and Nongdahe breeds 6 single nucleotide (C-2402T, C-2161G, T-2101G, C-2062G, T-2054A, G-2040A) 1 24-bp indel (insertion-deletion) at site -358 revealed large breed differences allelic frequencies all but T-2101G T-2054A...
BioMart is a freely available, open source, federated database system that provides unified access to disparate, geographically distributed data sources. It designed be agnostic and platform independent, such existing databases can easily incorporated into the framework. allows hosted on different servers presented seamlessly users, facilitating collaborative projects between research groups. contains several levels of query optimization efficiently manage large sets offers diverse selection...
Gossypium raimondii is a Verticillium wilt-resistant cotton species whose genome encodes numerous disease resistance genes that play important roles in the defence against pathogens. However, characteristics of gene analogues (RGAs) and dahliae response loci (VdRLs) have not been investigated on global scale. In this study, RGA were systematically analysed using bioinformatics-driven methods. Moreover, potential VdRLs involved to wilt identified by RNA-seq correlations with known QTLs.The G....
The wide application of immune checkpoint inhibitors has significantly improved the survival expectation cancer patients. While immunotherapy brings benefits to patients, it also results in a series immune-related adverse events (irAEs). Increasing evidence suggests that gut microbiome is critical for response and development irAEs.In this prospective study, we recruited 95 patients with advanced/unresectable gastrointestinal cancers treated report comprehensive analysis association irAEs....
Nucleotide-binding leucine-rich repeat (NLR) disease resistance genes typically confer against races of a single pathogen. Here, we report that Yr87/Lr85, an NLR gene from Aegilops sharonensis and longissima, confers both P. striiformis tritici (Pst) Puccinia triticina (Pt) cause stripe leaf rust, respectively. Yr87/Lr85 Pst Pt in wheat introgression as well transgenic lines. Comparative analysis the cloned Triticeae shows contains two distinct LRR domains is only found Ae. longissima....
Powdery mildew, caused by Blumeria graminis f. sp. tritici, is one of the most important wheat diseases in world. In this study, a single dominant powdery mildew resistance gene MlIW172 was identified IW172 wild emmer accession and mapped to distal region chromosome arm 7AL (bin7AL-16-0.86-0.90) via molecular marker analysis. closely linked with RFLP probe Xpsr680-derived STS Xmag2185 EST markers BE405531 BE637476. This suggested that might be allelic Pm1 locus or new Pm1. By screening...
The wax (glaucousness) on wheat leaves and stems is mainly controlled by two sets of genes: glaucousness loci (W1 W2) non-glaucousness (Iw1 Iw2). (Iw) act as inhibitors the (W). High-resolution comparative genetic linkage maps Iw1 originating from Triticum dicoccoides, Iw2 Aegilops tauschii were developed genomics analyses Brachypodium, sorghum rice genomic sequences corresponding to syntenic regions Iw in wheat. Eleven eight linked EST markers mapped distal chromosomes 2BS 2DS,...
BACKGROUND Currently, the role of UPR signaling in prostate cancer (PCa) is unclear. To evaluate relationship between pathway and prognosis PCa, we explored expression IRE1, PERK, ATF6 tissues. METHODS A total 160 PCa 30 benign hyperplasia (BPH) tissues were collected. The factors was assessed by immunohistochemistry. staining characteristics identified evaluated for associations with clinicopathologic parameters, PSA recurrence survival, cancer‐specific morality. RESULTS expressions ATF6α,...
To elucidate the association between nerve growth factor (NGF) level and bladder pain syndrome/interstitial cystitis (BPS/IC) by conducting a meta-analysis.We conducted systematic literature search to identify original studies of NGF in BPS/IC before November 2015. Eligible were retrieved via both computer searches manual review references. The summary difference estimates controlled group calculated based on weighted mean (WMD) with its 95 % confidence interval (CI). Sensitivity publication...