A5100761538- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- RNA Research and Splicing
- Renal and related cancers
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Phytochemistry and biological activity of medicinal plants
- Metabolism, Diabetes, and Cancer
- Marine Sponges and Natural Products
- Insect Resistance and Genetics
- Prostate Cancer Treatment and Research
- Proteoglycans and glycosaminoglycans research
- Seaweed-derived Bioactive Compounds
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Bioactive Compounds and Antitumor Agents
- Insect-Plant Interactions and Control
- Cardiac Ischemia and Reperfusion
- Ion Channels and Receptors
China National Institute of Standardization
2020-2024
Ocean University of China
2022-2024
China Light Industry Press (China)
2024
Zhongda Hospital Southeast University
2014-2023
Xuzhou Central Hospital
2023
Xuzhou Medical College
2023
Jiamusi University
2020-2023
Zhejiang University
2014-2023
Minzu University of China
2022
Institute of Crop Sciences
2022
Minsheng You and colleagues report the whole-genome sequence of diamondback moth, Plutella xylostella. Their transcriptome analysis from different life stages, together with comparative genomic phylogenetic analysis, provides insights into herbivore evolution insect adaptation to plant feeding detoxification. How an evolves become a successful is profound biological practical importance. Herbivores are often adapted feed on specific group evolutionarily biochemically related host plants1,...
Abstract Accumulated evidence indicates that CCAT1 functions as an oncogene in the progression of a variety tumors. However, little is known to how impacts tumorigenesis human prostate cancer. In this study, we found from The Cancer Genome Atlas and Memorial Sloan Kettering Center database highly upregulated castration-resistant cancer (CRPC) compared with androgen-dependent (ADPC). Higher level leads increased mortality patients CRPC. vitro vivo studies show promotes cell proliferation well...
A new TiIII -mediated reductive epoxide-opening/ Beckwith-Dowd rearrangement process efficiently assembles the bicyclo[3.2.1]octane framework of highly oxidized grayanane diterpenoids. By incorporation a Cu(tbs)2 -catalyzed (tbs=N-tert-butylsalicylaldiminato) intramolecular cyclopropanation, diastereoselective oxidative dearomatization-induced Diels-Alder cycloaddition and MeReO3 Rubottom oxidation, this approach has enabled first total syntheses rhodomolleins XX XXII in 23 22 steps, respectively.
Prostate cancer (PCa) is one of the leading causes deaths in America. The major cause mortality can be attributed to metastasis. Cancer metastasis involves sequential and interrelated events. miRNAs epithelial-mesenchymal transition (EMT) are implicated this process. miR-195 downregulated many human cancers. However, roles PCa EMT remain unclear. In study, data from Memorial Sloan Kettering Center (MSKCC) prostate database were re-analysed detect expression its PCa. was then overexpressed...
Saturated fatty acids (SFAs) generally have been thought to worsen insulin-resistance and increase the risk of developing type 2 diabetes mellitus (T2DM). Recently, accumulating evidence has revealed that SFAs are not a single homogeneous group, instead different associated with T2DM in opposing directions. Pentadecanoic acid (C15:0, PA) is directly correlated dairy products, negative association between circulating PA metabolic disease was observed epidemiological studies. Therefore, role...
The asymmetric total synthesis of (−)-retigeranic acid A was described, which relies on a crucial reductive skeletal rearrangement cascade for the controllable assembly diverse angular triquinane subunits. Taken together with an intramolecular Michael/aldol cyclization, ODI-[5 + 2] cycloaddition/pinacol cascade, Wolff ring contraction and stereoselective HAT reduction, our synthetic approach has enabled access to in concise practical manner.
In the present study, we theoretically investigated mechanism and origin of stereoselectivity in an NHC-catalyzed enantioselective activation/transformation α-bromo enal, utilizing α,β-unsaturated acyl azolium as a key intermediate...
MicroRNAs (miRNAs) play a significant role in tumor development. Recent studies indicate that miRNAs are implicated prostate cancer (PCa). In this study, we found miR‐19a expression was significantly increased castration‐resistant (CRPC) tissues compared with androgen‐dependent (ADPC) tissues. We inhibiting the overexpression of CRPC cells suppressed proliferation and apoptosis. Additionally, repressed BTG1 by binding to its 3′‐untranslated region. The conclude regulates apoptosis directly...
Accumulated evidence indicate that miR-744 functions as either tumor suppressor or oncogene in the progression of a variety tumors, with type-specific way. However, little is known about how impacts on tumorigenesis human prostate cancer. In this study, employing analyses microarray, qRT-PCR and re-analysis MSKCC data, we found CRPC tissues expressed much more than ADPC did, expression level was inversely associated survival patients. vitro studies revealed promotes PCa cells proliferation,...
A novel alpha-galactosidase gene (aga2) was cloned from Bifidobacterium breve 203. It contained an ORF of 2226-bp nucleotides encoding 741 amino acids with a calculated molecular mass 81.5 kDa. The recombinant enzyme Aga2 heterogeneously expressed, purified and characterized. Regarding substrate specificity for hydrolysis, highly active towards p-nitrophenyl-alpha-d-galactopyranoside (pNPG). Km value pNPG estimated to be 0.27 mM melibiose it 4.3 mM. capable catalyzing transglycosylation as...
Abstract The oncogenic fusion protein AML1-ETO retains the ability of AML1 to interact with enhancer core DNA sequences, but blocks AML1-dependent transcription. Previous studies have shown that post-translational modification may play a role in its regulation. Here we report AML1-ETO-positive patients, high histone lysine methyltransferase Enhancer zeste homolog 1 (EZH1) expression, show worse overall survival than those lower EZH1 expression. knockdown impairs and proliferation...
Clinical management of metastatic prostate cancer remains a challenge. Activation apoptosis signaling pathways via signal transducer and activator transcription 6 (STAT6) has been hypothesized to be therapeutic strategy for patients with cancer. The ONCOMINE® database two Gene Expression Omnibus datasets (Gene Series 40026 21032) were re‑analyzed determine the expression levels STAT6 microRNA (miR)‑135a in current study investigated induced overexpression miR‑135a cell lines detect its...