A5102005867- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Cancer-related gene regulation
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Antifungal resistance and susceptibility
- Lung Cancer Treatments and Mutations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
Dalian Medical University
2021-2025
Zhejiang University
2012-2025
First Affiliated Hospital Zhejiang University
2018-2025
Kunming Children's Hospital
2025
Kunming Medical University
2023-2025
Capital Medical University
2010-2025
Beijing Anzhen Hospital
2020-2025
Shinawatra University
2025
Shanghai East Hospital
2005-2025
Shandong University
2025
The proteasome was validated as an oncology target following the clinical success of VELCADE (bortezomib) for injection treatment multiple myeloma and recurring mantle cell lymphoma. Consequently, several groups are pursuing development additional small-molecule inhibitors both hematologic solid tumor indications. Here, we describe MLN9708, a selective, orally bioavailable, second-generation inhibitor that is in phase I development. MLN9708 has shorter dissociation half-life improved...
Abstract Activation of T cells is a necessary step in the development specific antitumor immune response. In present study, we evaluated ability Gr-1+ myeloid cells, derived from bone marrow or spleen tumor-bearing mice, to inhibit CD3/CD28-mediated cell activation. Using flow cytometry, found that growth murine colon carcinoma (MCA-26) induces significant increase number and Gr-1+/Mac-1+ both tumor host. The proliferative response was dramatically decreased when naive were activated by...
Generation of CD8(+) memory T cells requires antigenic stimulation through cell receptor (TCR); however, maintenance seems to be mediated by cytokines, such as IL-15, in a TCR-independent manner. Compared with the TCR-induced activation, less is known about mechanisms IL-15 action. We report here comparative and kinetic analysis responses phenotype or TCR (anti-CD3) vitro. These two stimuli induce highly similar measured cellular proliferation, gene expression changes, synthesis effector...
Widespread provision of human embryonic stem cells (hESCs) for therapeutic use, drug screening and disease modelling will require cell lines sustainable over long periods in culture. Since the short-term, vitro culture mammalian embryos can result DNA methylation changes, epigenetic stability hESCs warrants investigation. Existing hESC have been derived cultured under diverse conditions, providing potential programming differential changes into epigenome that may inter-line variability above...
Ovarian cancer is the most lethal gynecological malignancy with high recurrence rates and low survival rates, remaining a disease of unmet need. Cancer immunotherapy, which harnesses potential immune system to attack tumors, has emerged as one promising treatment options in recent years. As an important form dendritic cell (DC)-based vaccines have demonstrated ability induce response, while clinical efficacy DC remains unsubstantiated long-term benefit only reported restricted proportion...
Lack of immunogenicity cancer cells has been considered a major reason for their failure in induction tumor specific T cell response. In this paper, we present evidence that decitabine (DAC), DNA methylation inhibitor is currently used the treatment myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and other malignant neoplasms, capable eliciting an anti-tumor cytotoxic lymphocyte (CTL) response mouse EL4 model. C57BL/6 mice with established tumors were treated DAC (1.0 mg/kg body...
Highlights•Incidence of invasive fungal disease was 7.7% overall; 9.0% allogeneic hematopoietic stem cell transplantation and 4.3% autologous transplantation.•Cumulative incidence increased steeply the first month after transplantation.•Antifungal prophylaxis independently protective against disease.•Therapeutic antifungal rate 40.6% (36.7% treated in hospital, whom 82.3% received empirical treatment).•Invasive substantially mortality.AbstractThe China Assessment Antifungal Therapy...
An efficient non-noble bifunctional electrocatalyst for both the oxygen evolution reaction (OER) and hydrogen (HER) in same electrolyte.
Purpose: To evaluate the long-term efficacy and safety of secukinumab in pediatric patients with generalized pustular psoriasis (GPP).
Abstract The translocation t(8;21)(q22;q22) in acute myeloid leukemia (AML) results the expression of fusion protein RUNX1/MTG8, which turn recruits histone deacetylases (HDAC) to silence RUNX1 target genes [e.g., interleukin-3 (IL-3)].We previously reported that RUNX1/MTG8 gene IL-3 is synergistically restored by combination inhibitors HDACs (i.e., depsipeptide) and DNA methyltransferases (DNMT; i.e., decitabine) RUNX1/MTG8-positive Kasumi-1 cells. Thus, we hypothesized DNMT1 also part...
We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1, HRX, and HTRX1), consisting an in-frame partial tandem duplication (PTD) exons 5 through 11 in the absence partner gene, occurring approximately 4%-7% patients with acute myeloid (AML) normal cytogenetics, associated poor prognosis. The mechanism by which MLL PTD contributes to aberrant hematopoiesis and/or is unknown. To examine this, we generated mouse knockin model murine Mll were targeted...
miR-203 is a tumour suppressor microRNA (miRNA). We studied the methylation of hsa-miR-203 in 150 samples including acute myeloid leukaemia (AML), lymphoblastic (ALL), chronic (CML), lymphocytic (CLL) and non-Hodgkin's lymphoma (NHL) by methylation-specific PCR, miRNA expression stem-loop RT-qPCR. promoter was unmethylated normal controls but homozygously methylated two AML four cell lines, which 5-Aza-2'-deoxycytidine treatment led to demethylation re-expression. Restoration cells inhibited...
AML1-ETO fusion protein (AE) is generated by t(8;21)(q22;q22) chromosomal translocation, which one of the most frequently observed structural abnormalities in acute myeloid leukemia (AML) and displays a pivotal role leukemogenesis. The histone acetyltransferase p300 promotes self-renewal cells acetylating AE facilitating its downstream gene expression as transcriptional coactivator, suggesting that may be potential therapeutic target for AE-positive AML. However, effects inhibitors on...
COPD (chronic obstructive pulmonary disease) is associated with sustained inflammation, excessive injury, and accelerated lung aging. Human Klotho (KL) an anti-aging protein that protects cells against inflammation damage. In the present study, we quantified KL expression in lungs of patients ozone-induced mouse model COPD, investigated mechanisms control function airways. distribution levels human airways were measured by immunohistochemistry Western blotting. The effect CSE (cigarette...