A5101937759- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Conducting polymers and applications
- Advanced Photocatalysis Techniques
- Cancer-related gene regulation
- Copper-based nanomaterials and applications
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Ferroptosis and cancer prognosis
- ZnO doping and properties
- Circular RNAs in diseases
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Cancer Mechanisms and Therapy
- Perovskite Materials and Applications
- Immune cells in cancer
- Ginseng Biological Effects and Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Bioactive Compounds and Antitumor Agents
- Cancer-related Molecular Pathways
Yangzhou University
2018-2025
Liaocheng People's Hospital
2017-2025
Macau University of Science and Technology
2016-2025
Chinese University of Hong Kong
2023-2024
University of Hong Kong
2022-2024
Shandong University of Technology
2022-2024
Nanjing Medical University
2024
Jiangsu Cancer Hospital
2024
Xinqiao Hospital
2024
Army Medical University
2023-2024
Curcumenol, an effective ingredient of Wenyujin, has been reported that exerted its antitumor potential in a few cancer types. However, the effect and molecular mechanism curcumenol lung are largely unknown. Here, we found induced cell death suppressed proliferation cells. Next, demonstrated ferroptosis was predominant method contributed to curcumenol-induced vitro vivo for first time. Subsequently, using RNA sequencing, long non-coding H19 (lncRNA H19) significantly downregulated cells...
Nearly half of all Asian non-small cell lung cancer (NSCLC) patients harbour epidermal growth factor receptor (EGFR) mutations, and first-generation EGFR tyrosine kinase inhibitors (TKIs) are one the first-line treatments that have improved outcomes these patients. Unfortunately, 20% can not benefit from treatment. The basis this primary resistance is poorly understood. Therefore, overcoming EGFR-TKI maintaining efficacy TKIs has become a key issue. β-Elemene, sesquiterpene compound...
Ovarian cancer is the most lethal gynecological malignancy with high recurrence rates and low survival rates, remaining a disease of unmet need. Cancer immunotherapy, which harnesses potential immune system to attack tumors, has emerged as one promising treatment options in recent years. As an important form dendritic cell (DC)-based vaccines have demonstrated ability induce response, while clinical efficacy DC remains unsubstantiated long-term benefit only reported restricted proportion...
Despite the high response rate after surgery and platinum-combination chemotherapy, treatment of ovarian cancer remains challenging due to tumor recurrence metastasis. Tumor-associated macrophages (TAMs) have been linked progression However, impact crosstalk between chemotherapy TAMs on unclear. Here, we demonstrated that cisplatin-stimulated classically activated (CAMs) promote cell migration by increasing CCL20 production, which activates its receptor CCR6 cells, triggering...
Because of the complexity cancer, a combination chemotherapy and gene therapy is an emerging treatment modality.To realize full potential this strategy, smart, highly biocompatible nanosystem that enables precise co-delivery small-molecule anticancer drugs small interfering RNA (siRNA) urgently needed.This study aimed to improve therapeutic effect against cervical cancer by using cell membrane-camouflaged nanoparticles for simultaneous delivery paclitaxel (PTX) siRNA targeting E7.Methods: By...
Glucocorticoids (GCs) overuse is associated with decreased bone mass and osseous vasculature destruction, leading to severe osteoporosis. Platelet lysates (PL) as a pool of growth factors (GFs) were widely used in local repair by its potent pro-regeneration pro-angiogenesis. However, it still seldom applied for treating systemic osteopathia due the lack suitable delivery strategy. The non-targeted distribution GFs might cause tumorigenesis other organs. In this study, PL-derived exosomes...
It is desirable to develop strain sensors with large stretchability, high sensitivity, and good anti-corrosive properties, due their promising applications in wearable electronics.
Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) of liquid biofluids enables the probing biomolecular markers for disease diagnosis, characterized as a time and cost-effective approach. It remains poorly understood fast deep diagnosis digestive tract cancers (DTC) to detect abundant changes select specific in broad spectrum molecular species. Here, we present diagnostic protocol DTC which in-situ blood-based ATR-FTIR spectroscopic data mining pathway was...
Introduction:: Triple-negative breast cancer (TNBC), an aggressive type of cancer, remains difficult to treat. Isoliquiritigenin (ISL) is a bioactive compound that insoluble in water and exhibits significant anti-TNBC activity. Methods:: Method: We previously prepared oral aqueous ISL@ZLH NPs; however, they were less stable freezing environment. Hence, the present study aimed improve stability NPs using cryoprotectants can withstand long storage times are effective TNBC treatment by creating...
Objectives: IMP7068 is a potent and selective inhibitor of WEE1 kinase. Following oral administration predominantly metabolized by CYP3A4 in the liver. The major metabolite, IMP7253, also pharmacologically active. Population pharmacokinetic (PK) modeling was conducted to characterize concentration-time profiles IMP7253 patients with advanced solid tumors.Methods: population PK analysis based on data from Phase 1 dose-escalation study (IMP7068-101). dataset contains 1006 1028 quantifiable...
Culturable airborne microorganisms significantly impact air quality and human health in urban forest land. Their concentrations serve as key indicators. Over a year, this study analyzed six stands within the Zhuyu Bay Scenic Area, Yangzhou, Jiangsu Province, China, to assess concentration characteristics seasonal variations. Results showed that bacterial peaked spring summer, while fungal were highest March. Microbial levels remained elevated from April June, with variations among stands. A...
ABSTRACT Globally, non‐small cell lung cancer (NSCLC) is the primary cause of cancer‐related deaths. Rutecarpine (RUT), a quinazolinocarboline alkaloid that naturally occurring and present in Chinese medicinal herbs, has been shown to have anticancer properties several lines. However, specific antitumor mechanisms RUT NSCLC remain unclear. This study demonstrates induces apoptosis significantly reduces viability effect achieved by stimulating intracellular ROS production, leading...
Abstract Non-alcoholic fatty liver disease (NAFLD) has been shown to influence breast cancer progression, but the underlying mechanisms remain unclear. In this study, we investigated impact of NAFLD on tumor growth and cell viability through potential mediator, hepatic fibroblast factor 21 (FGF21). Both peritumoral systemic administration FGF21 promoted growth, while knockout attenuated tumor-promoting effects high-fat diet. Mechanistically, exogenous treatment enhanced anti-apoptotic...