A5052517378- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Mechanisms of cancer metastasis
- Breast Cancer Treatment Studies
- Metabolism, Diabetes, and Cancer
- Kruppel-like factors research
- RNA and protein synthesis mechanisms
- Immune Cell Function and Interaction
- Fibroblast Growth Factor Research
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Cancer-related gene regulation
- Cancer-related cognitive impairment studies
Sun Yat-sen University
2015-2025
Sun Yat-sen University Cancer Center
2015-2025
State Key Laboratory of Oncology in South China
2014-2022
Chinese People's Liberation Army
2021
University of Alabama
2018
Distant metastasis remains the major cause of morbidity for breast cancer. Individuals with liver or brain have an extremely poor prognosis and low response rates to anti-PD-1/L1 immune checkpoint therapy compared those at other sites. Therefore, it is urgent investigate underlying mechanism resistance develop more effective immunotherapy strategies these patients. Using single-cell RNA sequencing, a high-resolution map entire tumor ecosystem based on 44 473 cells from cancer metastases...
Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading cause of death. Our previous studies have shown that TNBC progression greatly facilitated by circKIF4A, but uncertainty remains regarding its role in brain and molecular mechanism. In this study, we found notable upregulation circKIF4A cell lines metastases. Inhibition impaired ability to proliferate, migrate, metastasis. Luciferase reporter assays confirmed competed for binding miR-637 STAT3 3’ UTR....
This study aims to explore the function and mechanism of G Protein-coupled receptor class C group 5 member A (GPRC5A) in docetaxel-resistance liver metastasis breast cancer.
Macrophages can be polarized into functional classically activated (M1) or alternatively (M2) phenotype. Tumor-associated macrophages (TAMs) mainly exhibit M2 Previous works determined that up-regulation of enolase 2 (ENO2) in diffuse large B-cell lymphoma (DLBCL) cells promote to an M2-like phenotype, thereby consequently promoting the progression DLBCL. Exosomes are a subset extracellular vesicles, carrying various bioactive molecules, mediate signals transduction and regulate immune...
Abstract The cancer stem cell (CSC) hypothesis suggests that a subset of cells possesses properties and is crucial in tumor initiation, metastasis, drug resistance. To determine the mechanism CSCs breast cancer, we focused on LGR5, marker adult potentially serves as functional factor CSCs. LGR5 overexpression was detected significantly associated with recurrence poor outcome. promoted mobility, formation, epithelial-mesenchymal transition by activating Wnt/β-catenin signaling. In addition,...
Abstract Lactate dehydrogenase A (LDHA) is involved in a variety of cancers. The purpose this study was to investigate the expression, prognostic roles and function LDHA breast cancer. We found that upregulated both cancer cell lines clinical specimens using quantitative real-time PCR (qRT-PCR). Immunohistochemistry (IHC) analysis tissue microarrays (TMAs) showed high expression associated with proliferation, metastasis poor patient overall survival (OS) disease free (DFS). Furthermore, we...
// Cailu Song 1, * , Long-Zhong Liu 2, Xiao-Qing Pei Xiaoping 1 Lu Yang Feng Ye Xinhua Xie Jianping Chen 3 Hailin Tang Xiaoming Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou, Guangdong, China 2 Ultrasond, School Chinese The Hong Kong, Kong These authors have contributed equally to this work Correspondence to: Xie, e-mail: xiexm@sysucc.org.cn Tang, tanghl@sysucc.org.cn...
Triple-negative breast cancer is the most aggressive subtype. The aim of our study was to investigate functional role both miR-101 and MCL-1 in sensitivity human triple-negative (TNBC) paclitaxel. We found that expression strongly decreased tissues cell lines. not associated with clinical stage or lymph node infiltration TNBC. Ectopic overexpression inhibit growth induced apoptosis vitro suppressed tumorigenicity vivo. significantly overexpressed TNBC Luciferase assay results confirmed as a...
In the central nervous system diseases, glioma is one of most common malignancies around world. Despite recent improvements in therapies for glioma, prognosis some high-risk remains poor. isoliquiritigenin (ISL) reported to have antioxidative and antitumor activities. However, potential mechanisms between ISL circle RNAs (circRNAs) tumorigenesis process not yet been reported. Here, we treated cells with ISL, circRNA expression levels were detected. Circ0030018 was found significantly...
Background and aim:As non-coding RNAs, circular RNAs (circRNAs) contribute to the progression of malignancies by regulating various biological processes.In prostate cancer, however, there is still a lack understanding regarding potential molecular pathways roles circRNAs.Methods: Loss-off function experiments were performed investigate circRNA in cancer.Western blot, qRT-PCR, IHC assay used examine expression level different genes or circRNAs.Further biology conducted uncover mechanism...
Introduction: Despite the abundance of research indicating participation immune cells in prostate cancer development, establishing a definitive cause-and-effect relationship has proven to be difficult undertaking. Methods: This study employs Mendelian randomization (MR), leveraging genetic variables related from publicly available genome-wide association studies (GWAS), investigate this association. The primary analytical method used is inverse variance weighting (IVW) analysis....
To the Editor: Neoadjuvant chemotherapy (NAC) significantly improves prognosis for patients with breast cancer internal mammary lymph node (IMN) involvement,[1] but locoregional treatment of IMNs including IMN dissection (IMND) and boost irradiation (IMNB) has long been debated,[2] owing to difficulty in surgical approaches cardiopulmonary side effects caused by high-dose radiation.[3] date, is rarely performed; thus, data regarding survival outcome IMND quite limited. In terms radiotherapy...
Long non-coding RNA (lncRNA) Actin filament-associated protein1-antisense 1 (AFAP1-AS1) is overexpressed in various types of cancers and plays important roles tumor progression prognosis. This study investigates the role AFAP1-AS1 triple-negative breast cancer (TNBC). We found that was TNBC tissues cells. Overexpression lncRNA associated with poor prognosis patients. Moreover, we demonstrated upregulation promoted cell proliferation invasion, inhibited apoptosis vitro, while overexpression...
This study explored the expression, biological function and prognostic role of SOX2 in triple negative breast cancer (TNBC). Quantitative real-time PCR (qRT-PCR) immunohistochemistry (IHC) were used to detect expression TNBC cell lines clinical tissues. MTT assay, Transwell flow cytometry xenograft mouse model assess functions SOX2. It was found that up-regulated both High associated with shorter overall survival (OS) disease free (DFS). Moreover, inhibition suppressed proliferation...
// Peng Liu 1, 2, * , Feng Ye Xinhua Xie Xing Li 2 Hailin Tang Shuaijie Xiaojia Huang Cailu Song Weidong Wei Xiaoming 1 Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People's Republic China State Key Laboratory Oncology in South China, Collaborative Innovation Center for Medicine, These authors have contributed equally to this work Correspondence to: Xie, e-mail: xiexm@sysucc.org.cn Wei, weiwd@sysucc.org.cn Keywords: mir-101-3p, AMPK, triple...
Abstract Background Metabolic disturbance is a hallmark of cancers. Targeting key metabolic pathways and metabolism‐related molecular could be potential therapeutic approach. Uncoupling protein 2 (UCP2) plays pivotal part in the malignancy cancer its capacity to develop resistance pharmaceutical interventions. However, it unclear about mechanism how UCP2 acts tumor growth reprogramming process non‐small cell lung (NSCLC). Methods Here, we conducted qRT‐PCR investigate expression both NSCLC...
Abstract More sensitive and effective diagnostic markers for the detection of breast cancer are urgently needed. The microRNA-183/182/96 cluster has been reported to be involved in tumorigenesis progression a variety cancers it is promising prognostic biomarker. goal this study was determine expression levels miR-183/182/96 tissues evaluate its role cancer. Real-time quantitative polymerase chain reaction analysis (qRT-PCR) used detect 41 adjacent normal (control tissues) also different...
Different breast cancer subtypes show distinct tropisms for sites of metastasis. Notably, the lung is most common site first distant recurrence in triple-negative (TNBC). The identification novel biomarkers metastasis great importance to improving outcome TNBC. In this study, we sought identify a microRNA (miRNA)-based biomarker and therapeutic target A total 669 patients without de novo stage IV TNBC were recruited study. miRNA profiling was conducted discovery cohort. Diagnostic accuracy...