A5007017195- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Cancer Mechanisms and Therapy
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Plant biochemistry and biosynthesis
- Ginseng Biological Effects and Applications
- Molecular Biology Techniques and Applications
- Bioactive natural compounds
- Plant-based Medicinal Research
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- Genomics and Phylogenetic Studies
- Berberine and alkaloids research
- Caveolin-1 and cellular processes
- Eicosanoids and Hypertension Pharmacology
- Phytochemical compounds biological activities
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Magnolia and Illicium research
- Plant-derived Lignans Synthesis and Bioactivity
Sichuan University
2018-2025
Sichuan Agricultural University
2021-2024
Taian City Central Hospital
2024
Shandong Agricultural University
2023
Southwestern Institute of Physics
2023
Chengdu University of Traditional Chinese Medicine
2015-2022
State Key Laboratory of Biotherapy
2022
Shengli Oilfield Central Hospital
2021-2022
Neijiang Normal University
2019
Chinese University of Hong Kong
2019
In the central nervous system diseases, glioma is one of most common malignancies around world. Despite recent improvements in therapies for glioma, prognosis some high-risk remains poor. isoliquiritigenin (ISL) reported to have antioxidative and antitumor activities. However, potential mechanisms between ISL circle RNAs (circRNAs) tumorigenesis process not yet been reported. Here, we treated cells with ISL, circRNA expression levels were detected. Circ0030018 was found significantly...
Cutibacterium acnes ( C. ) is a major pathogen implicated in the evolution of acne inflammation. Inhibition -induced inflammation prospective therapy strategy. Berberine (BBR), safe and effective natural ingredient, has been proven to exhibit powerful antimicrobial anti-inflammatory properties. However, effect BBR against its role -mediated inflammatory have not explored. The objective this investigation was assess antibacterial activity s inhibitory on response. results vitro experiments...
Abstract Triple‐negative breast cancer (TNBC) is the most aggressive and lethal clinical subtype lacks effective targeted therapies at present. Isobavachalcone (IBC), main active component of Psoralea corylifolia L., has potential anticancer effects. Herein, we identified IBC as a natural sirtuin 2 (SIRT2) inhibitor characterized mechanisms underlying inhibition TNBC. Molecular dynamics analysis, enzyme activity assay, cellular thermal shift assay were performed to evaluate combination...
Triple-negative breast cancer (TNBC) is a subtype of that accounts for the largest proportion cancer-related deaths. Thus, it imperative to search novel drug candidates with potent anti-TNBC effects. Recent studies suggest isoliquiritigenin (ISL) can significantly suppress growth, migration, and invasion cells. We previously synthesized ISL derivatives found 3',4',5',4″-tetramethoxychalcone (TMC) inhibits TNBC cell proliferation greater degree than ISL. The present study aimed investigate...
Breast cancer ranks as the leading cause of death in lethal malignancies among women worldwide, with a sharp increase incidence since 2008. Triple negative breast (TNBC) gives rise to largest proportion cancer-related deaths because its aggressive growth and rapid metastasis. Hence, searching for promising targets innovative approaches is indispensable TNBC treatment. Maackiain (MA), natural compound multiple biological activities, could be isolated from different Chinese herbs, such...
Abstract Objectives Doxorubicin (DOX) is a chemotherapy drug for treating malignant tumours. However, its cardiotoxicity has limited clinical application. The Radix Aconiti Lateralis Preparata, also known as Fuzi, been used heart failure. Nevertheless, there still deficiency of claeity to whether the Fuzi polysaccharide (FPS) may prevent side effects DOX. Methods Mice were intraperitoneally administered DOX (15 mg/kg) establish mouse model DOX-induced chronic (DICC). mice then different...
Although there is evidence of the association between RA and NSCLC, little known about their interaction mechanisms. The aim this study to identify potential hub genes biological mechanism in NSCLC via integrated bioinformatics analysis. gene expression datasets were downloaded discover validate genes. After identifying DEGs, we performed enrichment analysis, PPI network construction module selection validation Moreover, selected PTPRC for prognosis immune mutation methylation analysis...
Abstract Melatonin has been reported to have tumor-suppressive effects via comprehensive molecular mechanisms, and long non-coding RNAs (lncRNAs) may participate in this process. However, the mechanism by which melatonin affects function of lncRNAs triple-negative breast cancer (TNBC), most aggressive subtype cancer, is still unknown. Therefore, we aimed investigate differentially expressed mRNAs melatonin-treated TNBC cells interaction mechanisms. Microarray analyses were performed identify...
The environmental adaptation of eudicots is the most reasonable explanation for why they compose largest clade modern plants (>70% angiosperms), which indicates that basal would be valuable and helpful to study their survival ability thrive throughout evolutionary processes. Here, we detected two whole-genome duplication (WGD) events in high-quality assembled Akebia trifoliata genome (652.73 Mb) with 24 138 protein-coding genes based on evidence intragenomic intergenomic collinearity,...
Mastitis is one of the most prevalent diseases dairy cows. Currently, mastitis treatment in cows mainly based on antibiotics. However, use antibiotics causes adverse effects, including drug resistance, residues, host-microbiome destruction, and environmental pollution. The present study sought to investigate potentiality geraniol as an alternative for bovine Additionally, effectiveness treatment, improvement inflammatory factors, influence microbiome, presence resistance induction were...