A5100344458- Genomics and Phylogenetic Studies
- Retinoids in leukemia and cellular processes
- Microbial Community Ecology and Physiology
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- Berberine and alkaloids research
- Cholesterol and Lipid Metabolism
- Traditional Chinese Medicine Analysis
- Bacteriophages and microbial interactions
- Gut microbiota and health
- Acupuncture Treatment Research Studies
- Antioxidant Activity and Oxidative Stress
- Peroxisome Proliferator-Activated Receptors
- Plant Disease Resistance and Genetics
- Protein Kinase Regulation and GTPase Signaling
- Fermentation and Sensory Analysis
- Probiotics and Fermented Foods
- Chromosomal and Genetic Variations
- Horticultural and Viticultural Research
- Plant biochemistry and biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Plant and animal studies
- Natural Compounds in Disease Treatment
Ningbo University
2012-2025
Yunnan Agricultural University
2016-2025
Anshun University
2025
Beijing University of Chinese Medicine
2009-2024
The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine
2024
Zhongda Hospital Southeast University
2024
Shandong First Medical University
2022-2024
Fourth People's Hospital of Sichuan Province
2024
Nanjing University of Chinese Medicine
2022-2024
Ningbo Medical Center Lihuili Hospital
2024
We have produced a draft sequence of the rice genome for most widely cultivated subspecies in China, Oryza sativa L. ssp. indica , by whole-genome shotgun sequencing. The was 466 megabases size, with an estimated 46,022 to 55,615 genes. Functional coverage assembled sequences 92.0%. About 42.2% exact 20-nucleotide oligomer repeats, and transposons were intergenic regions between Although 80.6% predicted Arabidopsis thaliana genes had homolog rice, only 49.4% A. . large proportion no...
PCSK9 is a natural inhibitor of LDL receptor (LDLR) that binds the extracellular domain LDLR and triggers its intracellular degradation. are coordinately regulated at transcriptional level by sterols through their promoter-imbedded sterol response elements (SRE) co-induced statins. Identification regulatory networks modulating transcription important for developing selective repressors to improve statin efficacy prolonging up-regulation LDLR. Interestingly, plant-derived hypocholesterolemic...
The large yellow croaker Larimichthys crocea (L. crocea) is one of the most economically important marine fish in China and East Asian countries. It also exhibits peculiar behavioral physiological characteristics, especially sensitive to various environmental stresses, such as hypoxia air exposure. These traits may render L. a good model for investigating response mechanisms stress. To understand molecular genetic underlying adaptation stress, we sequenced assembled genome using bacterial...
Abstract Understanding the Vitis species at genomic level is important for cultivar improvement of grapevine. Here we report whole-genome genetic variation single-base resolution 472 accessions, which cover 48 out 60 extant from a wide geographic distribution. The helps to identify recent dramatic expansion and contraction effective population size in domesticated grapevines that cultivars pan-Black Sea region have unique demographic history comparison other cultivars. We also find selective...
We elucidate grapevine evolution and domestication histories with 3525 cultivated wild accessions worldwide. In the Pleistocene, harsh climate drove separation of grape ecotypes caused by continuous habitat fragmentation. Then, occurred concurrently about 11,000 years ago in Western Asia Caucasus to yield table wine grapevines. The domesticates dispersed into Europe early farmers, introgressed ancient western ecotypes, subsequently diversified along human migration trails muscat unique...
Human kinesin family member 11 (KIF11) plays a vital role in regulating the cell cycle and is implicated tumorigenesis progression of various cancers, but its endometrial cancer (EC) still unclear. Our current research explored prognostic value, biological function targeting strategy KIF11 EC through approaches including bioinformatics, machine learning experimental studies. The GSE17025 dataset from GEO database was analyzed via limma package to identify differentially expressed genes...
Large numbers of inbred laboratory rat strains have been developed for a range complex disease phenotypes. To gain insights into the evolutionary pressures underlying selection these phenotypes, we sequenced genomes 27 strains, including 11 models hypertension, diabetes, and insulin resistance, along with their respective control strains. Altogether, identified more than 13 million single-nucleotide variants, indels, structural variants across Analysis strain-specific selective sweeps gene...
Abstract Recent studies found that membrane-bound K-Ras dimers are important for biological function. However, the structure and thermodynamic stability of these complexes remained unknown because they hard to probe by conventional approaches. Combining data from a wide range computational experimental approaches, here we describe structure, dynamics, energetics mechanism assembly multiple dimers. Utilizing techniques detection reactive surfaces, protein-protein docking molecular...
Macrofungus is defined as the fungus that grows an observable sporocarp. The sporocarps of many species are commonly called mushrooms and consumed by people all around world food and/or medicine. Most macrofungi belong to divisions Basidiomycetes Ascomycetes, which estimated contain more than 80,000 in total. We report draft genome assemblies (83 7 Ascomycetes species) based on Illumina sequencing. sizes these ranged from 27.4 Mb (Hygrophorus russula) 202.2 MB (Chroogomphus rutilus). numbers...
Abstract Background Danshen (Salvia miltiorrhiza Bunge), also known as Chinese red sage, is a member of Lamiaceae family. It valued in traditional medicine, primarily for the treatment cardiovascular and cerebrovascular diseases. Because its pharmacological potential, ongoing research aims to identify novel bioactive compounds danshen, their biosynthetic pathways. To date, only expressed sequence tag (EST) RNA-seq data this herbal plant are available public. We therefore propose that...
Lactobacillus plantarum strain ST-III, a probiotic with several functions, was isolated from kimchi. Here we report the complete genome sequence of ST-III and compared it two published L. genomes.
The atypical AGC kinase Greatwall (Gwl) mediates a pathway that prevents the precocious removal of phosphorylations added to target proteins by M phase-promoting factor (MPF); Gwl is thus essential for phase entry and maintenance. itself activated phase-specific are investigated here. Many nonessential, being located within long nonconserved region, any part which can be deleted without effect. Using mass spectrometry mutagenesis, we have identified 3 phosphorylation sites (phosphosites)...
Maca (Lepidium meyenii Walp, 2n = 8x 64), belonging to the Brassicaceae family, is an economic plant cultivated in central Andes sierra Peru (4000-4500 m). Considering that rapid uplift of occurred 5-10 million years ago (Ma), evolutionary question arises regarding how plants such as maca acquire high-altitude adaptation within a short geological period. Here, we report high-quality genome assembly maca, which two closely spaced maca-specific whole-genome duplications (WGDs; ∼6.7 Ma) were...
Family samples, which can be enriched for rare causal variants by focusing on families with multiple extreme individuals and facilitate detection of de novo mutation events, provide an attractive resource next-generation sequencing studies. Here, we describe, implement, evaluate a likelihood-based framework analysis next generation sequence data in family samples. Our is able to identify variant sites accurately assign individual genotypes, handle increasing the sensitivity specificity...
Panax notoginseng (2n = 2x 24), reputed as a valuable medicinal plant, belongs to the Araliaceae family (Figure 1a). P. has been used traditional Chinese medicine with obvious efficacy and favourable safety. Currently, is an important material of many well-known patent medicines including Xuesaitong, Yunnan Baiyao Compound Danshen Dripping Pills (Xu et al., 2019). Triterpenoid saponins (TSs) dencichine are main bioactive compounds in notoginseng. The therapeutic effects TSs include...
Numerous genes have been associated with multiple morphological abnormalities of the sperm flagella (MMAF), which cause severe asthenozoospermia and lead to male infertility, while causes approximately 50% MMAF cases remain unclear. To reveal genetic in an infertile patient, whole-exome sequencing was performed screen for pathogenic genes, electron microscope used flagellar ultrastructure. A novel heterozygous missense mutation outer dense fiber protein 2 (ODF2) gene detected, inherited from...