A5100457999- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Mesenchymal stem cell research
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Immune Cell Function and Interaction
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- T-cell and B-cell Immunology
- Mitochondrial Function and Pathology
- Cardiac Structural Anomalies and Repair
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Electrospun Nanofibers in Biomedical Applications
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Effects of Exercise
- Protease and Inhibitor Mechanisms
Zhejiang University
2016-2025
Second Affiliated Hospital of Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2000-2025
Second Affiliated Hospital of Nanjing Medical University
2022-2025
Nanjing Medical University
2025
Jiangnan University
2023-2025
China Agricultural University
2024
Anhui Medical University
2018-2024
Blood Center of Zhejiang Province
2015-2024
Weihai Chest Hospital
2024
<h3>Importance</h3> Uncertainty remains about the efficacy of folic acid therapy for primary prevention stroke because limited and inconsistent data. <h3>Objective</h3> To test hypothesis that with enalapril is more effective in reducing first than alone among Chinese adults hypertension. <h3>Design, Setting, Participants</h3> The China Stroke Primary Prevention Trial, a randomized, double-blind clinical trial conducted from May 19, 2008, to August 24, 2013, 32 communities Jiangsu Anhui...
Abstract Our group recently reported positive therapeutic benefit of human endometrium-derived mesenchymal stem cells (EnMSCs) delivered to infarcted rat myocardium, an effect that correlated with enhanced secretion protective cytokines and growth factors compared parallel cultures bone marrow MSCs (BMMSCs). To define more precisely the molecular mechanisms EnMSC therapy, in present study, we assessed paracrine properties derived from endometrium, marrow, adipose tissues a model myocardial...
Rationale : Autophagy can preserve cell viability under conditions of mild ischemic stress by degrading damaged organelles for ATP production, but severe ischemia, it promote death and worsen cardiac performance. Mesenchymal stem cells (MSCs) are cardioprotective when tested in animal models myocardial infarction, whether these benefits occur through the regulation autophagy is unknown. Objective: To determine transplanted MSCs reduce rate autophagic degradation (autophagic flux) infarcted...
Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim this study was to investigate whether exosomes from hypoxia-treated MSCs (ExoH) are superior those normoxia-treated (ExoN) for myocardial repair. Mouse bone marrow-derived were cultured under hypoxia or normoxia 24 h, and conditioned media intramyocardially injected into infarcted heart C57BL/6 mouse. ExoH resulted in significantly higher survival, smaller scar size better cardiac functions recovery....
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have been widely used for treating myocardial infarction (MI). However, low retention and short-lived therapeutic effects are still significant challenges. This study aimed to determine whether incorporation of MSC-derived sEVs in alginate hydrogel increases their the heart thereby improving effects. Methods: The optimal sodium incorporating system was determined by its release ability rheology hydrogel. Ex...
Extracellular vesicles containing miR-486-5p augment angiogenesis after MI in mice and nonhuman primates by targeting fibroblastic Mmp19 .
CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (TRM) cell phenotype are associated favorable prognosis in patients triple-negative breast cancer (TNBC). However, the relative contribution of TRM cells to anti-tumor immunity and immune checkpoint blockade efficacy remains unknown. Here, we show that intratumoral murine mammary tumors transcriptionally resemble those from TNBC patients. Phenotypic transcriptional studies established two sub-populations: one more enriched...
Cardiovascular disease (CVD) has increasing challenges for human health with an increasingly aging population worldwide, imposing a significant obstacle to the goal of healthy aging. Rapid advancements in our understanding biological process have shed new light on some important insights aging-related diseases. Although numerous reviews delved into mechanisms through which affects CVD and age-related diseases, most these relied heavily research related cellular molecular processes often...
Abstract Calcific aortic valve disease is a prevalent cardiovascular with no available drugs capable of effectively preventing its progression. Hence, an efficient drug delivery system could serve as valuable tool in screening and potentially enhance therapeutic efficacy. However, due to the rapid blood flow rate associated stenosis lack specific markers, achieving targeted for calcific has proved be challenging. Here we find that protease-activated-receptor 2 (PAR2) expression up-regulated...
Cardiac fibrosis is a common feature in left ventricular remodeling that leads to heart failure, regardless of the cause. EphrinB2 (erythropoietin-producing hepatoma interactor B2), pivotal bidirectional signaling molecule ubiquitously expressed mammals, crucial angiogenesis during development and disease progression. Recently, was reported protect kidneys from injury-induced fibrogenesis. However, its role cardiac remains be clarified.We sought determine underlying mechanisms pathological...
We sought to describe the morphological characteristics of aortic valve disease in a Chinese population presenting for transcatheter replacement (TAVR).Racial and regional differences are known exist stenosis (AS), but limited data comparing specific anatomical variations between populations.Patients were prospectively evaluated TAVR Venus A-Valve trial, first trial evaluating China. A systematic assessment protocol employed contrast-enhanced computed tomography (CT) all cases.A total 120...
The hydrodynamics and mixing process within droplets travelling along a three dimensional serpentine microchannel have been studied using computational fluid dynamics simulation based on the volume-of-fluid approach.
Heart failure (HF) is among the leading causes of morbidity and mortality, its prevalence continues to rise. LARP7 (La ribonucleoprotein domain family member 7) a master regulator that governs DNA damage response RNAPII (RNA polymerase II) pausing pathway, but role in HF pathogenesis incompletely understood. We assessed expression human nonhuman primate mouse models. To study function heart, we generated global cardiac-specific knockout mice. acutely abolished mature cardiomyocytes by...
The incidence and severity of acute kidney injury (AKI) is increased yearly in diabetic patients. Although the mechanisms for this remain unclear, prevention AKI nephropathy feasible value. As we detected highly activation TGF-β/Smad3 signaling both human biopsy mouse model nephropathy, hypothesized that Smad3 kidneys may increase sensitivity. We tested our hypothesis vitro using TGF-β type II receptor (TGF-βRII) disrupted tubular epithelial cells (TECs) vivo mice with streptozotocin...
The regulation of the informational flow from mitochondria to nucleus (mitonuclear communication) is not fully characterized in heart. We have determined that mitochondrial ribosomal protein S5 (MRPS5/uS5m) can regulate cardiac function and key pathways coordinate this process during stress. demonstrate loss Mrps5 developing heart leads defects embryonic lethality while postnatal induces hypertrophy failure. structure disrupted mutant cardiomyocytes, impairing translation OXPHOS. identify...
The index of microcirculatory resistance is a reliable measure for evaluating coronary microvasculature, but its prognostic value in patients with non–ST-segment elevation myocardial infarction (NSTEMI) remains unclear. This study aimed to evaluate the impact post–percutaneous intervention (PCI) angiography-derived (angio-IMR) NSTEMI. culprit vessel's angio-IMR was measured after PCI 2,212 NSTEMI at 3 sites. primary endpoint 2-year major adverse cardiac events (MACEs), defined as composite...
We previously pioneered a negatively ionized polyethylene terephthalate membrane method (the SMART technique) with the LAMax (test) occluder to reduce platelet adhesion and promote endothelialization. This study aimed compare safety efficacy of test Watchman 2.5 device (control) in patients nonvalvular atrial fibrillation stroke risk. Overall, 236 were randomly assigned (1:1) (open-label) or control for left appendage occlusion (LAAO). The effectiveness endpoints included 12-month successful...
The electron transfer from NAD(P)H to heme is a rate-limiting step in the redox partner-mediated catalysis of P450 enzyme. However, due lack efficient engineering strategies, it difficult improve properties partner. Herein, we construct an effective approach modify partner for typical enzyme (OleP) that can catalyze stereoselective conversion lithocholic acid murideoxycholic acid. Firstly, combination computational modeling and experimental validation was performed rapidly identify most...