A5100735429- Gut microbiota and health
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Monoclonal and Polyclonal Antibodies Research
- Aortic aneurysm repair treatments
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- T-cell and B-cell Immunology
- MRI in cancer diagnosis
- Genetic Mapping and Diversity in Plants and Animals
- Clostridium difficile and Clostridium perfringens research
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Acute Myocardial Infarction Research
- Mesenchymal stem cell research
- Diet and metabolism studies
- Ginseng Biological Effects and Applications
- Single-cell and spatial transcriptomics
- Advanced MRI Techniques and Applications
- Probiotics and Fermented Foods
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Diagnosis and Treatment
Yunnan University
2020-2025
Zhejiang Sci-Tech University
2025
Shandong First Medical University
2020-2025
Yangzhou University
2018-2025
Second Affiliated Hospital of Zhejiang University
2025
Purdue University West Lafayette
2025
Puer University
2025
Jining First People's Hospital
2025
Henan Academy of Sciences
2025
Liaoning Cancer Hospital & Institute
2025
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells. We identified 1,234 high confidence clusters of which 94% are projected to be bona fide ERalpha regions. Only 5% the located within 5 kb upstream transcriptional start adjacent genes, regions containing proximal promoters, whereas vast majority intronic or distal locations (>5 from 5' 3' ends transcript), suggesting...
Abstract Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of complex interaction between gut microbiota and brain. Here we explore fecal microbiome based on 90 medication-free schizophrenia 81 controls identify microbial species classifier distinguishing with...
Importance Programmed cell death ligand 1 inhibitors combined with chemotherapy has changed the approach to first-line treatment in patients extensive-stage small lung cancer (SCLC). It remained unknown whether adding a programmed (PD-1) inhibitor provided similar or better benefits SCLC, which would add evidence on efficacy of checkpoint SCLC. Objective To evaluate and adverse event profile PD-1 serplulimab plus compared placebo as Design, Setting, Participants This international,...
We report the discovery and characterization of SM-406 (compound 2), a potent orally bioavailable Smac mimetic an antagonist inhibitor apoptosis proteins (IAPs). This compound binds to XIAP, cIAP1, cIAP2 with Ki 66.4, 1.9, 5.1 nM, respectively. Compound 2 effectively antagonizes XIAP BIR3 protein in cell-free functional assay, induces rapid degradation cellular cIAP1 protein, inhibits cancer cell growth various human lines. It has good oral bioavailability mice, rats, non-human primates,...
De novo mutations (DNMs) are important in Autism Spectrum Disorder (ASD), but so far analyses have mainly been on the ~1.5% of genome encoding genes. Here, we performed whole sequencing (WGS) 200 ASD parent-child trios and characterized germline somatic DNMs. We confirmed that majority DNMs (75.6%) originated from father, these increased significantly with paternal age only (p=4.2×10-10). However, when clustered (those within 20kb) were found ASD, not did they mostly originate mother...
Abstract The COVID-19 pandemic has accounted for millions of infections and hundreds thousand deaths worldwide in a short-time period. patients demonstrate great diversity clinical laboratory manifestations disease severity. Nonetheless, little is known about the host genetic contribution to observed interindividual phenotypic variability. Here, we report first study Chinese population by deeply sequencing analyzing 332 categorized varying levels severity from Shenzhen Third People’s...
Abstract To explore potential intermediate host of a novel coronavirus is vital to rapidly control continuous COVID-19 spread. We found genomic and evolutionary evidences the occurrence 2019-nCoV-like (named as Pangolin-CoV) from dead Malayan Pangolins. Pangolin-CoV 91.02% 90.55% identical at whole genome level 2019-nCoV BatCoV RaTG13, respectively. lowest common ancestor RaTG13. The S1 protein much more closely related than Five key amino-acid residues involved in interaction with human...
Abstract SARS-CoV-2 is the cause of COVID-19. It infects multiple organs including respiratory tract and gut. Dynamic changes regional microbiomes in infected adults are largely unknown. Here, we performed longitudinal analyses throat anal swabs from 35 COVID-19 19 healthy adult controls, as well 10 non-COVID-19 patients with other diseases, by 16 S rRNA gene sequencing. The results showed a partitioning into 3-4 categories based on microbial community types (I-IV) both sites. bacterial...
Abstract MicroRNAs (miRs) play an important role in regulating gene expression. Limited by their instabilities, miR therapeutics require delivery vehicles. Tetrahedral framework nucleic acids (tFNAs) are potentially applicable to drug because they prominently penetrate tissue and taken up cells. However, tFNA‐based strategies have failed separate the miRs after enter cells, affecting efficiency. In this study, RNase H‐responsive sequence is applied connect a sticky‐end tFNA (stFNA) miR‐2861,...
Abstract Imbalance of macrophage polarization characterized by an increase in the percentage pro‐inflammatory M1 macrophages and a decrease anti‐inflammatory M2 is considered critical pathogenic mechanism bisphosphonate‐related osteonecrosis jaws (BRONJ). Because high levels Toll‐like receptor 4 (TLR4) mediates mitochondrial dyshomeostasis Zoledronic Acid (ZA)‐treated macrophages, tetrahedral DNA nanomaterial (TDN)‐modified with TLR4‐siRNA on each vertex (TDN‐TLR4‐4siR) excellent...
MicroRNAs (miRNAs) have been implicated in the maintenance of cancer stem cell (CSC) phenotype via their ability to affect expression genes and proteins that regulate proliferation and/or death. Thus, identification CSC-related miRNAs would provide information for a better understanding CSCs. Here, we compared miRNA profiles CD133+ CD133- primary hepatocellular carcinoma (HCC) subpopulations found upregulation 5 subpopulations, including hsa-miR-150, which may be involved liver CSC...
Abstract Osteoarthritis, a disorder characterized by articular cartilage deterioration, varying degrees of inflammation, and chondrocyte apoptosis, is the most common chronic joint disease. To slow or reverse its progression, inflammation should be inhibited, proliferation promoted. Tetrahedral framework nucleic acids can internalized chondrocytes (even inflammatory chondrocytes) enhance their migration. Wogonin, naturally occurring flavonoid, suppresses oxidative stress inhibits...
Abstract The oral microbiota contains billions of microbial cells, which could contribute to diseases in many body sites. Challenged by eating, drinking, and dental hygiene on a daily basis, the is regarded as highly dynamic. Here, we report significant human genomic associations with metagenome from more than 1915 individuals, for both tongue dorsum ( n = 2017) saliva 1915). We identified five genetic loci associated at study-wide significance p < 3.16 × 10 −11 ). Four were well...
Abstract The gut microbiome has been established as a key environmental factor to health. Genetic influences on the have reported, yet, doubts remain significance of genetic associations. Here, we provide shotgun data for whole genome and metagenome from Chinese cohort, identifying no <20% contribution microbiota. Using common variants-, rare copy number variations-based association analyses, identified abundant signals associated with especially in metabolic, neurological, immunological...