A5102838548- Retinal Diseases and Treatments
- Nanoplatforms for cancer theranostics
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Extracellular vesicles in disease
- Advanced Drug Delivery Systems
- Graphene and Nanomaterials Applications
- Adipokines, Inflammation, and Metabolic Diseases
- T-cell and B-cell Immunology
- Adenosine and Purinergic Signaling
- Autoimmune and Inflammatory Disorders Research
- Retinal and Optic Conditions
- Circular RNAs in diseases
- Genetic and Kidney Cyst Diseases
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Hypoxia, and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Protease and Inhibitor Mechanisms
- Systemic Lupus Erythematosus Research
- Retinopathy of Prematurity Studies
- Ocular Diseases and Behçet’s Syndrome
- Ferroptosis and cancer prognosis
- Cerebrospinal fluid and hydrocephalus
- Pulmonary Hypertension Research and Treatments
- Immune Cell Function and Interaction
Heze Medical College
2024
Jilin University
2019-2024
University College London
2024
Jilin Medical University
2021
Health Commission of Jilin Province
2021
University of Wisconsin–Madison
2020
Anhui Medical University
2016
Tumor drug resistance has long been a major challenge in medical oncology. Ferroptosis is form of regulated cell death with promising clinical applications. However, the efficacy ferroptosis-inducing agents often limited by endogenous factors when used alone, and thus, synergistic therapy offers strategy to address this issue. In study, we developed an iron-doped metal-organic framework (MOF), Fe/ZIF-8, loaded glucose oxidase (Gox), l-arginine (l-arg), adriamycin hydrochloride (Dox). The...
Age-related macular degeneration is a multifactorial disease involving inflammation and choroidal neovascularization. Vascular endothelial growth factor (VEGF) has been regarded as potential therapeutic target to treat Dexamethasone can interfere with the expression or action of VEGF while bevacizumab targets combines VEGF. We propose electrostatically-conjugated bevacizumab-bearing dexamethasone-loaded poly (D,L-lactide-co-glycolide)/polyethylenimine nanoparticles (eBev-DPPNs) for...
The development of cell-like nanoreactors with the ability to initiate biocatalytic cascades under special conditions holds tremendous potential for therapeutic applications. Herein, conformationally gated that respond acidic microenvironment infected diabetic wounds were developed by cucur[8]bituril (CB[8])-based supramolecular assembly. bioinspired exhibit not only self-regulated permeability and selectivity control internal enzyme activities substance exchange but also distinct binding...
Bevacizumab, a vascular endothelial growth factor (VEGF)-targeting drug, is widely used as an off-label therapeutic for age-related macular degeneration (AMD). To reduce the monthly administration frequency, this study investigated microspheres comprising poly(d, l-lactide-co-glycolide)/poly(cyclohexane-1,4-diyl acetone dimethylene ketal) (PLGA/PCADK) blend that could be loaded with bevacizumab-dextran particles using solid-in-oil-in-water (S/O/W) emulsification. Control were also prepared...
The synergy of photothermal therapy (PTT) and chemotherapy is widely regarded as an effective treatment for complex diseases, such cancer inflammation. In this paper, we report the synthesis a nanoscaled drug delivery system, which was composed gold nanorod (GNR) agent mesoporous silica shell methotrexate (MTX) reservoir, named FAGMs. Due to folate modification on surface, FAGMs targeted specifically activated macrophages in rheumatoid arthritis (RA). Under 808 nm laser irradiation, could...
Vascular endothelial growth factor (VEGF) expression increased significantly in the pathogenesis of age-related macular degeneration, which induced formation pathological blood vessels. Dexamethasone is an exogenous anti-angiogenic drug while bevacizumab endogenous drug. They both have been widely used ophthalmology. However, independent administration not enough to completely block development choroidal neovascularization (CNV), and number eyes vitreous injections limited. Reasonable...
The rapid advancements in gene therapy have opened up new possibilities for the treatment of genetic disorders, including Duchenne muscular dystrophy, Thalassemia, cystic fibrosis, Hemophilia, and Familial hypercholesterolemia. utilization clustered regularly interspaced short palindromic repeats (CRISPR) - CRISPR-associated protein (Cas) system has revolutionized field by enabling precise targeting genes. In recent years, CRISPR/Cas9 demonstrated remarkable efficacy treating cancer...