A5100719573- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Bone health and osteoporosis research
- Tendon Structure and Treatment
- Hip and Femur Fractures
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Exercise and Physiological Responses
- Chronic Disease Management Strategies
- Entomological Studies and Ecology
- Pharmacological Effects of Natural Compounds
- Human Health and Disease
- Medicinal Plants and Bioactive Compounds
- dental development and anomalies
- Metabolism and Genetic Disorders
- Peripheral Neuropathies and Disorders
- Renal Diseases and Glomerulopathies
- Tensor decomposition and applications
- Infectious Aortic and Vascular Conditions
- Vasculitis and related conditions
- Healthcare Systems and Public Health
- Aortic aneurysm repair treatments
- Single-cell and spatial transcriptomics
- Medical and Agricultural Research Studies
Zhongda Hospital Southeast University
2021-2023
Guangzhou University
2023
Southeast University
2022
BGI Group (China)
2016-2022
Anhui Medical University
2010-2022
Southeast University
2017-2022
BGI Genomics
2022
Shenzhen Genoimmune Medical Institute
2022
Peking University First Hospital
2022
Peking University
2022
Idiopathic membranous nephropathy (MN) is associated with HLA; however, the HLA allele involved remains unknown. To identify risk alleles phospholipase A2 receptor (PLA2R)-related MN in Chinese population, we sequenced entire MHC region DNA samples from 99 patients PLA2R-related MN, 50 PLA2R-unrelated and 100 healthy subjects. Two alleles, HLA-DRB1*15:01 HLA-DRB3*02:02, independently strongly an increased of MN. After adjusting for no other showed significant association A replication study...
Diminished regeneration or healing capacity of tendon occurs during aging. It has been well demonstrated that stem/progenitor cells (TSPCs) play a vital role in maintenance and repair. Here, we identified an accumulation senescent TSPCs tissue with In aged TSPCs, the activity JAK-STAT signaling pathway was increased. Besides, genetic knockdown JAK2 STAT3 significantly attenuated TSPC senescence TSPCs. Pharmacological inhibition AG490 similarly cellular senescence-associated secretory...
Objective The strong genetic contribution of the major histocompatibility complex (MHC) region to rheumatoid arthritis (RA) has been generally attributed human leukocyte antigen ( HLA)-DRB1 . However, due high polymorphisms and linkage disequilibrium within MHC, it is difficult define novel and/or independent risks using conventional HLA genotyping or chip-based microarray technology. This study aimed identify RA risk variants by performing deep sequencing for MHC. Methods We first conducted...
The 3 major subphenotypes observed in patients with nonsyndromic orofacial clefts (NSOFCs) are cleft lip only (NSCLO), palate (NSCLP), and (NSCPO). However, the genetic architecture underlying NSCPO is largely unknown. Here we performed a 2-stage genome-wide association study (GWAS) on replication analyses of selected variants other NSOFCs from Chinese Han population. We identified novel locus (15q24.3) known (1q32.2) where or near gene reached significance (2.80 × 10 −13 < P 1.72 −08 )...
T cells recognize antigens as peptides bound to major histocompatibility complex (MHC) proteins through cell receptors (TCRs) on their surface. To a wide range of pathogens, each individual possesses substantial number TCRs with an extremely high degree variability. It remains controversial whether germline-encoded TCR repertoire is shaped by MHC polymorphism and, if so, what the preference between genetic variants and V gene compatibility. investigate "net" association variations TRBV...
HLA-DRB3, DRB4 and DRB5 (DRB3/4/5) are paralogues of HLA-DRB1. They have important roles in transplantation been reported to be related many diseases. HLA typing methods for DRB3/4/5 based on NGS data limitations now, such as need polymerase chain reaction (PCR) or low accuracy.We present a method read mapping haplotype assembly from data. Also, copy number is determined by k-means clustering according ratio sequencing depth between DRB1.We achieved 100%, 100% accuracy simulated 95.88%,...
Protein-truncating variants (PTVs) have important impacts on phenotype diversity and disease. However, their population genetics characteristics in more globally diverse populations are not well defined. Here, we describe patterns of PTVs 1320 genes sequenced 10,539 healthy controls 9434 patients with psoriasis, all Han Chinese ancestry. We identify 8720 PTVs, which 77% novel, estimate 88% deleterious subject to purifying selection. Furthermore, show that individuals psoriasis a...
Massive multiple-input multiple-output (MIMO) systems employ a large number of antennas to achieve gains in capacity, spectral efficiency, and energy efficiency. However, the antenna array also incurs substantial storage computational costs. This paper proposes novel data compression framework for massive MIMO channel matrices based on tensor Tucker decomposition. To address burdens systems, we formulate high-dimensional as tensors propose groupwise decomposition model. model efficiently...
Isolated thoracic aortic aneurysms (TAAs) are asymptomatic before dissection or rupture and heterogeneous in clinical phenotype. It is urgent need but difficult to identify individuals at high risk enable enhanced screening preventive therapies. Because TAAs have a genetic component, one possible approach stratify based on inherited DNA variations. Here, we constructed an integrated exome score (ERS) both common rare variants found whole-exome sequencing through machine-learning framework...
Abstract T cells recognize antigens as peptides bound to major histocompatibility complex (MHC) proteins through cell receptors (TCRs) on their surface. To a wide range of pathogens, each individual possesses substantial number TCRs with an extremely high degree variability. It remains controversial whether germline-encoded TCR repertoire is shaped by MHC polymorphism and, if so, what the preference between genetic variants and V gene compatibility. investigate “net” association variations...
Abstract Background This paper aimed to review the databases on non-displaced femoral neck fractures in elderly patients. We also discussed surgical and non-surgical treatments selection of implants. Methods Reviewed was literature Four major medical a combination search terms “femoral fractures”, “nondisplaced”, “undisplaced”, “non-displaced”, “un-displaced”, “aged”, “the elderly”, “geriatric” were used relevant topic review. Results Patients who unable tolerate operation anesthesia could...
ABSTRACT The strong genetic contribution of the major histocompatibility complex (MHC) to rheumatoid arthritis (RA) susceptibility has been generally attributed HLA-DRB1 . However, due high linkage disequilibrium in MHC region, it is difficult define ‘real’ or/and additional independent risks using conventional HLA genotyping or chip-based microarray technology. By capture sequencing entire region for discovery and HLA-typing validation 2,773 subjects Han ancestry, we identified...
Abstract Background The number of patients with osteoporosis or low bone mass is increasing annually. Weight loss reportedly associated and a strong predictor osteoporosis. It was still not clear the relationship between weight in elder. Methods study included 520 aged ≥65 years (178 men 342 women). Age, gender, weight, height were recorded. Femoral neck mineral density T-score investigated using dual-energy X-ray absorptiometry scanner. Blood calcium (Ca), phosphorus (P), albumin (ALB),...
Background: Visceral adiposity index is a new type of indicator that accurately reflects distribution and function visceral fat. The relation between VAI new-onset hyperuricemia remains largely understudied. Purpose: This study sought to further investigate the prospective association risk by examining possible effect modifies in hypertensive patients. Methods: We enrolled 10,513 patients with normal uric acid (UA) concentrations (<357 μmol/L (6 mg/dL)) who participated UA Sub-study China...
Objective: To analyze the relationship between migration time and prevalence of myopia children adolescents aged 6 18 years old in Shenzhen. Methods: From April to May 2019, 26 618 from 14 schools six streets Baoan District, including Fuyong, Shajing, Xin'an, Xixiang, Songgang Shiyan, were included study by using random cluster sampling method. The demographic characteristics, status, self-reported myopia, screen last seven days, outdoor activities one month other information collected...