A5100323516- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Urinary Tract Infections Management
- Hydrogels: synthesis, properties, applications
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Neurogenesis and neuroplasticity mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacteriophages and microbial interactions
- Biochemical and Molecular Research
- Total Knee Arthroplasty Outcomes
- Psoriasis: Treatment and Pathogenesis
- Antimicrobial Peptides and Activities
- Microbial Natural Products and Biosynthesis
- Curcumin's Biomedical Applications
- Antimicrobial Resistance in Staphylococcus
- Tissue Engineering and Regenerative Medicine
- Nerve injury and regeneration
- Dermatology and Skin Diseases
- Bacterial Identification and Susceptibility Testing
- Mesenchymal stem cell research
- Inhalation and Respiratory Drug Delivery
First Affiliated Hospital of Anhui Medical University
2012-2025
Anhui Medical University
2014-2025
Fudan University
2021-2025
Beijing University of Chinese Medicine
2024
Hangzhou Medical College
2024
Peking Union Medical College Hospital
2013-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2023
South China Agricultural University
2022-2023
West China Hospital of Sichuan University
2022
Fujian Medical University
2022
To determine the health-related quality of life (HRQoL) COVID-19 patients after discharge and its predicting factors.COVID-19 has caused a worldwide pandemic led huge impact on health human daily life. It been demonstrated that physical psychological conditions hospitalised are impaired, but studies focus from hospital rare.A multicentre follow-up study.This was study who had discharged six designated hospitals. Physical symptoms HRQoL were surveyed at first (the third month discharge). The...
To evaluate in vitro susceptibilities of aerobic and facultative Gram-negative bacterial (GNB) isolates from intra-abdominal infections (IAIs) to 12 selected antimicrobials Chinese hospitals 2012 2014.Hospital acquired (HA) community (CA) IAIs were collected 21 centers 16 cities. Extended spectrum beta-lactamase (ESBL) status antimicrobial determined at a central laboratory using CLSI broth microdilution interpretive standards.From all isolated strains the Enterobacteriaceae (81.1%)...
Significance Bacteria can produce β-lactamases, enzymes that destroy β-lactam antibiotics and thereby resist these potent target cell wall synthesis. Production of β-lactamases is often controlled by β-lactam-induced perturbations in the wall. Here, we have identified a new mechanism controlling β-lactamase production. We found signaling system which membrane-associated histidine kinase directly binds β-lactams, triggering expression resistance to antibiotics. Direct sensing may enable...
Axonal demyelination is a consistent pathological characteristic of Spinal cord injury (SCI). Promoting differentiation oligodendrocytes importance for remyelination. Conversion reactive astrocytes with stem cell potential to proposed as an innovative strategy SCI repair. Neuregulin-1 (Nrg1) plays essential role in the oligodendrocytes. Therefore, it's treatment that using Nrg1 drive toward oligodendrocyte lineage cells. In this study, tumor necrosis factor-α (TNF-α) was used induce...
Abstract Thirteen curcuminoids (1–13) were isolated from the rhizomes of Curcuma longa . Among them, 1,5‐dihydroxy‐1,7‐bis(4‐hydroxyphenyl)‐4,6‐heptadiene‐3‐one (1), 1,5‐dihydroxy‐1‐(4‐hydroxy‐3‐methoxyphenyl)‐7‐(4‐hydroxyphenyl)‐4,6‐heptadiene‐3‐one (2), 1,5‐dihydroxy‐1‐(4‐hydroxyphenyl)‐7‐(4‐hydroxy‐3‐methoxyphenyl)‐4,6‐heptadiene‐3‐one (3), and 3‐hydroxy‐1,7‐bis‐(4‐hydroxyphenyl)‐6‐heptene‐1,5‐dione (4) are new compounds, 1‐(4‐hydroxyphenyl)‐7‐(3, 4‐dihydroxyphenyl)‐1, 6‐heptadiene‐3,...
Melittin is a water-soluble toxic peptide derived from the venom of bee. Although many studies show anti-tumor activity melittin in human cancer including glioma cells, underlying mechanisms remain elusive. Here effect on hepatocelluar carcinoma HepG2 cell proliferation vitro and further was investigated. We found could inhibit using Flow cytometry MTT method. Besides, we discovered that significantly downregulated expressions CyclinD1 CDK4. Results western Blot Real-time PCR analysis...
Rationale: Rheumatoid arthritis (RA) is a prototype of inflammatory in which synovial fibroblasts (SFs) play key roles cartilage and bone destruction through tumor-like proliferation, migration, invasion inflammation. This study aimed to research forkhead box protein C1 (FoxC1) microRNA (miR)-141-3p, modulate pathological changes the membrane, find possible strategies for treating RA. Methods: FoxC1, β-catenin miR-141-3p gene expression tissues SFs was quantified by real-time PCR; FoxC1...
The convergence of carbapenem-resistance and hypervirulence in Klebsiella pneumoniae has led to a significant public health challenge. In recent years, there have been more reports on carbapenem-resistant hypervirulent (CR-hvKP) isolates.Clinical data patients infected with CR-hvKP from January 2019 December 2020 tertiary hospital were retrospectively evaluated. number isolates pneumoniae, hypermucoviscous (hmKP), (CR-hmKP) collected during the period 2 years was calculated. antimicrobial...
The current idea that compensatory evolution processes can account for the “plasmid paradox” phenomenon associated with maintenance of large costly plasmids in host bacteria has attracted much attention. Although many mutations have been discovered through various plasmid-host bacterial experiments, basis mechanisms and nature themselves to address fitness costs remain unclear.
Hypervirulent carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) has recently aroused an extremely severe health challenge and public concern. However, the underlying mechanisms of fitness costs that accompany antibiotic resistance acquisition remain largely unexplored. Here, we report a hv-CRKP-associated fatal infection reveal reduction in virulence due to aminoglycoside resistance.The bacterial identification, antimicrobial susceptibility, hypermucoviscosity, factors, MLST serotypes...
The objective of this study was to investigate the susceptibility hospital-associated (HA) and community-associated (CA) Escherichia coli Klebsiella pneumoniae isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 2011, minimum inhibitory concentrations (MICs) 12 antibiotics against 3074 E. 1025 K. 23 centres located 16 cities were determined by broth microdilution method. During 10 year period, ertapenem, imipenem, amikacin piperacillin-tazobactam retained high...
Hydrogels have a wide range of applications in the fields biomedicine, flexible electronics, and bionics. In this study, injectable self-healable hydrogels were first prepared based on dynamic covalent C═C bond formed via Knoevenagel condensation reaction between poly(ethylene glycol) dicyanoacetate water-soluble poly(vanillin acrylate). Three kinds catalysts (phosphate buffer, zeolitic imidazolate framework-8, tertiary amine) used for preparing hydrogels. All study could be situ, their...
Short-stem total hip arthroplasty (SHA) has become popular because it preserves femoral bone stock and enables the use of short stems in revision (THA). However, no study evaluated whether a stem THA, replacing standard stem, can provide adequate primary stability to facilitate osseous integration. In this biomechanical study, metaphyseal anchoring SHA (Tri-Lock BPS) THA (Corail) were implanted into ten composite femurs loaded dynamically from 300 1700 N with 1 Hz. Primary was estimated...
AIM: To investigate changes in local brain activity after laser assisted situ keratomileusis (LASIK) myopia patients, and further explore whether post-LASIK (POL) patients healthy controls (HCs) can be distinguished by differences dynamic amplitude of low-frequency fluctuations (dALFF) specific regions. METHODS: The resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 15 myopic who underwent LASIK matched controls. This method was selected to calculate the...
KL1, KL2 CR-hvKP and KL64, KL47 hv-CRKP all exhibit overlapping multidrug resistance hypervirulence phenotypes, but the differences in epidemiological, phenotypic genotypic characteristics between them remains unclear. In this study, we collected non-repeated hv-CRKP/CR-hvKP isolates a tertiary hospital Shanghai, China from January 2019 to December 2022. Furthermore, selected four typical hypervirulent carbapenem-resistant Klebsiella pneumoniae, including ST23-KL1/ST86-KL2 (WYKP3 WYKP194)...
Metagenomic next-generation sequencing (mNGS) could improve the diagnosed efficiency of pathogens in bloodstream infections or sepsis. Little is known about clinical impact mNGS test when used for early diagnosis suspected infections. Herein, our main objective was to assess efficacy utilizing blood samples perform infections, as well evaluate its potential guiding antimicrobial therapy decisions.
In the present study, effects of chordin‑like protein 1 (CHRDL1) overexpression, together with bone morphogenetic protein‑4 (BMP‑4) treatment, on differentiation rat spinal cord‑derived neural stem cells (NSCs) was investigated. Adult NSCs were cultured in serum‑free medium. The recombined eukaryotic expression vector pSecTag2/Hygro B‑CHRDL1 transfected into adult using a lipid‑based transfection reagent and assessed by western blot analysis. Differentiation following BMP‑4 treatment...
Animal farms have become one of the most important reservoirs carbapenem-resistant Klebsiella spp. (CRK) owing to wide usage veterinary antibiotics. "One Health"-studies observing animals, environment, and humans are necessary understand dissemination CRK in animal breeding areas. Based on concept "One-Health," 263 samples feces, wastewater, well water, human feces from 60 livestock poultry Shandong province, China were screened for CRK. Five pneumoniae (CRKP) three quasipneumoniae (CRKQ)...
Considering the increasing incidence of carbapenem-resistant Enterobacteriaceae in China, this study aimed to establish vitro effectiveness imipenem/relebactam (IMI/REL) on clinical isolates derived from intra-abdominal infections (IAIs), respiratory tract (RTIs), and urinary (UTIs) China between 2015 2018.In total, 8781 IAI, RTI, UTI samples were collected 22 hospitals across 7 geographic regions China. Susceptibility antimicrobial drugs was tested using Clinical Laboratory Standards...