A5100362709- Dermatology and Skin Diseases
- Antibiotic Resistance in Bacteria
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Microbial Natural Products and Biosynthesis
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Stress Responses and Cortisol
- Fatty Acid Research and Health
- Hepatitis C virus research
- Estrogen and related hormone effects
- Genetic Associations and Epidemiology
- Climate Change and Health Impacts
- Mesenchymal stem cell research
- melanin and skin pigmentation
- Immune Response and Inflammation
- Neonatal skin health care
- Advancements in Transdermal Drug Delivery
- Microbial Metabolism and Applications
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Biochemical and Structural Characterization
Children's Hospital of Fudan University
2020-2025
Affiliated Hospital of Nantong University
2022-2025
Nantong University
2022-2025
Huazhong University of Science and Technology
2022-2025
Culture Resource
2025
First Affiliated Hospital of Anhui Medical University
2012-2024
Anhui Medical University
2012-2024
Nanjing Medical University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Gansu Provincial Center for Disease Control and Prevention
2018-2023
Prenyltransfer is an early-stage carbon–hydrogen bond (C–H) functionalization prevalent in the biosynthesis of a diverse array biologically active bacterial, fungal, plant, and metazoan diketopiperazine (DKP) alkaloids. Toward development unified strategy for biocatalytic construction prenylated DKP indole alkaloids, we sought to identify characterize substrate-permissive C2 reverse prenyltransferase (PT). As first tailoring event within cytotoxic notoamide metabolites, PT NotF catalyzes...
Metagenomic next-generation sequencing (mNGS) could improve the diagnosed efficiency of pathogens in bloodstream infections or sepsis. Little is known about clinical impact mNGS test when used for early diagnosis suspected infections. Herein, our main objective was to assess efficacy utilizing blood samples perform infections, as well evaluate its potential guiding antimicrobial therapy decisions.
By integrating heterologous expression of the entire biosynthetic gene cluster in Aspergillus nidulans and a building blocks-based molecular networking (BBMN) strategy, six novel aspertetronin dimers (diasperonins A-F, 1-6) with three unprecedented skeletons two additional congeners (7-8) were characterized from engineered strain. High monomer levels overexpression likely triggered nonenzymatic dimerization. Compound 7 suppressed NF-κB pathway LPS-induced RAW264.7 cells mouse model,...
Fifty extensively drug-resistant Acinetobacter baumannii (XDRAB) were isolated from patients. The chequerboard microdilution method was used to determine the in vitro activities of five colistin (COL)-based combinations including COL+fosfomycin (FOS), COL+rifampicin (RIF), COL+imipenem (IMP), COL+sulbactam (SUP) and COL+levofloxacin (LVX). synergistic activity evaluated by fractional inhibitory concentration index (FICI). According our results, combination COL with FOS, RIF, IMP, SUP LVX...
This study reevaluated the secular trends of blood pressure and hypertension prevalence in Chinese children adolescents by adjusting for growing body sizes.The population was from China Health Nutrition Survey (1991-2011) included 7358 boys 6881 girls aged 8-17 years. Body size measurements were standardized into z-scores using national references to allow comparisons among different age groups survey Prehypertension rates defined international age-specific height-specific references.SBP DBP...
ABSTRACT Dystrophic epidermolysis bullosa (DEB) is a genetic skin disease with limited therapeutic options for managing pruritus. This study retrospectively evaluated the efficacy and safety of Dupilumab monotherapy in patients DEB suffering from severe treated between June 2021 2023 were reviewed. severity pruritus intensity assessed using Birmingham Epidermolysis Bullosa Severity (BEBS, range 0–100) scores Numerical Rating Scale (NRS, 0–10), respectively. A linear mixed model was used to...
A variety of diseases are caused by chromosomal abnormalities such as aneuploidies (having an abnormal number chromosomes), microdeletions, microduplications, and uniparental disomy. High density single nucleotide polymorphism (SNP) microarrays provide information on copy changes, well genotype (heterozygosity homozygosity). SNP array studies generate multiple types data for each site, some with more than 100,000 SNPs represented array. The identification different classes anomalies within...
Dipyrithione (PTS2) possesses anti‐bacterial and anti‐fungal activity. In the present study, we found that PTS2 dose‐dependently inhibited LPS‐induced up‐regulation of nitric oxide synthase (iNOS) cyclooxygenase‐2 (COX‐2) protein level in RAW264.7 cells. RT‐PCR experiments showed suppressed iNOS but not COX‐2 expression at mRNA level. As expected, prevented NO secretion Furthermore, administration significantly decreased mortality mice. Mechanistically, phosphorylation STAT1, did interfere...
Bone marrow mesenchymal stem cells (BMSCs) represent a promising tool for cell-based therapies. However, the majority of BMSC transplants only allow limited recovery lost functions. We previously found that human cerebrospinal fluid (hCSF) is more potent than growth factors in differentiating BMSCs into neuron-like vitro. In this study, we studied effect transplantation rat BMSC-derived (BMSC-Ns) induced by hCSF brain with middle cerebral artery occlusion (MCAO). The survival and...
The anti-ageing gold standard, retinol, has been widely recognized for its anti-wrinkle benefits in the Chinese population. Studies have shown that Asians are more sensitive to retinol compared their Caucasian counterparts, and it is generally recommended use once a day evening. However, there few reports on most appropriate concentration frequency of general
Abstract Background Skin barrier functions develop after birth and may be related to skin disorders in infants. We aimed assess associations between dynamic trends of four functional parameters early life with infant atopic dermatitis (AD). Methods Based on the prospective cohort MKNFOAD (NCT02889081), we examined transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, sebum content at five anatomical sites (cheek, forehead, forearm, abdomen, lower leg) 418 term infants birth,...
A novel homologous polyketide dimer, asperosin (1), constructed with a unique hetero-bicycle 6/5 core skeleton featuring four continuous quaternary carbons, was isolated from solid culture of the fungus Aspergillus rugulosa .
Abstract Background Comorbidities of coronavirus disease 2019 (COVID-19)/coronary heart (CHD) pose great threats to outcomes, yet little is known about their shared pathology. The study aimed examine whether comorbidities COVID-19/CHD involved genetic pathology, as well clarify the variants predisposing risks common COVID-19 severity and CHD risks. Methods By leveraging publicly available summary statistics, we assessed genetically determined causality between with bidirectional Mendelian...
Abstract Background Trajectories of stratum corneum (SC) lipid subclasses and their associations with infant atopic dermatitis (AD) are unclear. This study aimed to quantify the trajectories 15 SC carbon chain lengths AD within 12 months. Methods In total, 213 newborns were enrolled at birth nonlesional skin samples collected from inner forearm birth, 42 days, 3, 6, months, respectively. Lesional 120 patients clinic disease onset first year life. Mass spectrometry was applied assess relative...