A5110389978- Antibiotic Resistance in Bacteria
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Escherichia coli research studies
- Enterobacteriaceae and Cronobacter Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Antimicrobial Peptides and Activities
- Liver Disease Diagnosis and Treatment
- Infections and bacterial resistance
- Antimicrobial Resistance in Staphylococcus
- Malaria Research and Control
- Gut microbiota and health
- Viral Infections and Vectors
- Vibrio bacteria research studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanoplatforms for cancer theranostics
- GaN-based semiconductor devices and materials
- ZnO doping and properties
- Antibiotic Use and Resistance
- Salmonella and Campylobacter epidemiology
- Aquaculture disease management and microbiota
Shenyang Pharmaceutical University
2025
Anhui Medical University
2015-2024
First Affiliated Hospital of Anhui Medical University
2015-2024
Children's Hospital of Zhejiang University
2024
Zhejiang University
2024
Chaohu Hospital of Anhui Medical University
2014-2023
Wuhan University of Technology
2022
Nanfang Hospital
2022
First Affiliated Hospital Zhejiang University
2022
Beijing YouAn Hospital
2022
Nanozymes that mimic peroxidase (POD) activity can convert H2O2 into bactericidal free radicals, which is referred to as chemodynamic therapy (CDT). High glutathione (GSH) levels in the infectious tissue severely limit performance of CDT. Herein, we report a near-infrared-controlled antibacterial nanoplatform based on encapsulating tungsten sulfide quantum dots (WS2QDs) and antibiotic vancomycin thermal-sensitive liposome. The system exploits photothermal sensitivity WS2QDs achieve selective...
Klebsiella (K.) pneumoniae is a common cause of pneumonia-derived sepsis in human and associated with high morbidity mortality. The microbiota promotes maintains host immune homeostasis during bacterial infections. However, the mechanisms by which gut affects responses lung still remain poorly understood. Here, we performed cecal metabolomics sequencing fecal 16s rRNA K. pneumoniae-infected mice uninfected controls showed that infection led to profound alterations microbiome thus metabolome....
Non-volatile memory (NVM) will play a very important role in the next-generation digital technologies, including Internet of things. The metal-oxide memristors, especially based on HfO2, have been favored by lots researchers because its simple structure, high integration, fast operation speed, low power consumption, and compatibility with advanced (complementary metal oxide silicon) CMOS technologies. In this paper, 20-level stable resistance states Al-doped HfO2-based memristor is...
The antimicrobial resistance pattern was studied among 300 Stenotrophomonas maltophilia isolates collected from nonduplicated inpatients. average age of the patients 73.5 ± 14.6 years old. Isolates nonsusceptible to levofloxacin, chloramphenicol, minocycline or trimethoprim/sulfamethoxazole (SXT) were more prevalent in 99 aged over 81 than other (p < 0.05). Multidrug found be significantly associated with recovered blood (72.7%, p = 0.000) and elderly (31.3%, 0.003). A trend increased...
Aspergillus-related disease was confirmed to be associated with immune disorders in patients, severe patients fever thrombocytopenia syndrome (SFTS) infected by novel phlebovirus were have damage including cellular immunosuppression and cytokine storms. Secondary invasive pulmonary aspergillosis (IPA) SFTS can increase fatality rate. This study investigated early-warning predictive factors of secondary IPA patients. Receiver operating characteristic analysis used assess the value parameters...
Haifei Yang, M.D., Guosheng Chen, Yulin Zhu, Yanyan Liu, Jun Cheng, Lifen Hu, Ying Ye, and Jiabin Li, M.D.. Ann Lab Med 2013;33:111-5. https://doi.org/10.3343/alm.2013.33.2.111
Treatment of Acinetobacter baumannii infections is challenging owing to widespread multidrug-resistant A. (MDR-AB) and the lack novel agents. Although recent data suggest that levofloxacin (LVX) may have unique activity against MDR-AB in combination with colistin (CST), further preclinical work needed.We used a type strain ATCC19606, CST-resistant AB19606R, two clinical isolates (GN0624 GN1115) investigate vitro vivo efficacy LVX-CST combination. Synergy studies were performed using...
To investigate the in vitro and vivo activity of imipenem-colistin combination against multidrug-resistant Enterobacter cloacae infections order to determine whether it should be explored further.The antimicrobial colistin alone with imipenem was assessed versus an imipenem-susceptible isolate, E. GN1059, or imipenem-resistant strain, GN0791, isolated Anhui, China. The potential synergy evaluated using a checkerboard assay, as well static time-kill experiments at 1× 2× minimum inhibitory...
Fifty extensively drug-resistant Acinetobacter baumannii (XDRAB) were isolated from patients. The chequerboard microdilution method was used to determine the in vitro activities of five colistin (COL)-based combinations including COL+fosfomycin (FOS), COL+rifampicin (RIF), COL+imipenem (IMP), COL+sulbactam (SUP) and COL+levofloxacin (LVX). synergistic activity evaluated by fractional inhibitory concentration index (FICI). According our results, combination COL with FOS, RIF, IMP, SUP LVX...
Spread of the carbapenemase-encoding and mobilized colistin resistance ( mcr ) genes among Enterobacteriales poses a great threat to global public health, especially when both are transferred by single plasmid. Here, we identified bla NDM– 1 - mcr-9 -co-encoding plasmid harbored clinical isolate Klebsiella pneumoniae (KPN710429). KPN710429 was recovered from blood sample an inpatient in tertiary hospital China, antimicrobial susceptibility testing showed that it multidrug-resistant only...
Childhood obesity presents a serious health concern associated with gut microbiota alterations. Dietary interventions targeting the have emerged as promising strategies for managing in children. This study aimed to elucidate impact of stachyose (STS) supplementation on composition and metabolic processes obese Fecal samples were collected from 40 children (20 boys 20 girls) aged between 6 15
Enterobacter cloacae is a well-recognized nosocomial pathogen. Use of rapid, in vivo infection model for E. that can determine the efficacy antibiotic therapies could help facilitate screening new treatments. Nonmammalian systems infection, such as Galleria mellonella, have significant logistical and ethical advantages over mammalian models. We utilized G. mellonella larvae to utility this study antibacterial efficacy. killing with heat-killed or live clinical isolates (E. GN1059 GN0791) was...
We examined the prevalence of plasmid–mediated quinolone resistance (PMQR) determinants among Acinetobacter baumannii in Anhui, China. And β–lactamase genes and mutations resistance–determining regions (QRDRs) were also investigated PMQR-positive isolates. Among 39 A. isolates, 3 (7.7%) isolates harbored qnrB 1 (2.6%) qnrS. Mutations QRDRs gyrA identified 2 amongst 4 Quinolone could be transferred by conjugation from all donors. In conclusion, more attention should taken to prevent...
Treatment of Staphylococcus aureus infections is challenging owing to widespread multidrug resistance. There now considerable interest in the potential combination therapies. Although linezolid/fosfomycin appears be a promising treatment option based on vitro data, further preclinical work needed. In this study, Galleria mellonella system was employed study vivo efficacy order determine whether it should explored for S. infections. The antimicrobial activity linezolid and fosfomycin alone...