A5100445803- Mass Spectrometry Techniques and Applications
- Inflammasome and immune disorders
- PI3K/AKT/mTOR signaling in cancer
- Bladder and Urothelial Cancer Treatments
- Microfluidic and Capillary Electrophoresis Applications
- Kawasaki Disease and Coronary Complications
- RNA modifications and cancer
- Analytical Chemistry and Chromatography
- Mitochondrial Function and Pathology
- Ion-surface interactions and analysis
- Immune cells in cancer
- Urinary and Genital Oncology Studies
- Wnt/β-catenin signaling in development and cancer
- Gout, Hyperuricemia, Uric Acid
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Viral Infections and Vectors
- Air Quality and Health Impacts
- Adrenal and Paraganglionic Tumors
- Toxoplasma gondii Research Studies
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury and Neurovascular Disturbances
- TGF-β signaling in diseases
- HER2/EGFR in Cancer Research
Northwest A&F University
2021-2024
Guangxi Medical University
2023
Huashan Hospital
2017-2022
Fudan University
1996-2022
Shanghai Eye Disease Prevention & Treatment Center
2022
Shandong Provincial Hospital
2015-2020
Shandong First Medical University
2020
Shandong University
2015-2018
Army Medical University
2015
Daping Hospital
2015
Viruses use diverse strategies to impair the antiviral immunity of host in order promote infection and pathogenesis. Herein, we found that PCV2 promotes DNA viruses through inhibiting IFN-β induction vivo vitro . In early phase infection, phosphorylation cGAS at S278 via activation PI3K/Akt signaling, which directly silences catalytic activity cGAS. Subsequently, can facilitate K48-linked poly-ubiquitination K389, been served as a signal for recognizing by ubiquitin-binding domain histone...
Background: We aimed to evaluate the prognostic value of site-specific metastases in patients with metastatic bladder cancer and analyze roles that surgeries play treatment this malignancy. Materials methods: A population-based retrospective study using Surveillance, Epidemiology End Results dataset was performed were classified according sites (bone, brain, liver, lung distant lymph nodes). Kaplan–Meier analysis log-rank test used for survival comparisons. Multivariate Cox regression model...
Pseudorabies virus (PRV) infection causes systemic inflammatory responses and damages in infected animals, which are associated with the activation of inflammasome pyroptosis tissues. Here, we identified a critical function PRV non-structural protein UL4 that enhanced ASC-dependent to promote pyroptosis. Whereas, deficiency viral was able reduce occurrences Mechanistically, 132–145 aa permitted its translocation from nucleus cytoplasm interact cytoplasmic ASC NLRP3 AIM2 inflammasome. Further...
In the range of miniature mass spectrometers, ion trap spectrometer with continuous atmospheric pressure interface (CAPI) shows good performance potential and advantages due to its excellent sensitivity analysis speed. However, in previous cases, placing directly near skimmer aperture means it will suffer high gas shock, which may affect performance. this study, an improved CAPI was developed by flow optimization. According experimental results, excessive affects stability resolution. The...
In this study, we investigated the antitumor activity of axitinib, a selective inhibitor vascular endothelial growth factor receptor tyrosine kinases, against melanoma cells. Axitinib dose-dependently inhibited proliferation and induced apoptosis B16F1 cells in vitro. mouse model xenograft, axitinib significantly suppressed tumor tissues at dose 25 mg/kg. addition, lung metastasis prolonged life span tumor-bearing mice. also enhanced proportion CD8⁺ T reduced myeloid-derived suppressor...
The concept and method for mass selective ion transfer accumulation within quadrupole trap arrays have been demonstrated. Proof-of-concept experiments performed on two sets of arrays: (1) a linear with axial ejection plus radial ejection; (2) ejection. In both arrays, ions trapped in the first could be selectively transferred accumulated into second trap, while keeping other reserved trap. Different operating modes implemented tested, including transferring all ions, selected range,...
Fibronectin (FN) is associated with tumorigenesis and progression in bladder cancer, however, the underlying mechanisms causing this remain largely unknown. Furthermore, cancerous inhibitor of protein phosphatase 2A (CIP2A) has been shown to play important regulatory roles cancer proliferation. Here, we investigated whether FN regulates CIP2A expression promote cell The correlations stromal proliferating nuclear antigen (PCNA) were analyzed a cohort patients. regulating proliferation...
Various small molecule GLP1R agonists have been developed and tested for treating type 2 diabetes (T2DM) obesity. However, many of these new compounds drawbacks, such as potential hERG inhibition, lower activity compared to natural GLP-1, limited oral bioavailability in cynomolgus monkeys, short duration action. Recently, a category 3-phenyloxetane derivative with enhanced inhibition has discovered. Using an AIDD/CADD method, compound 14 (DD202-114) was identified potent selective agonist,...
// Xiaogang Sun 1 , Shuhong Huang 2 Xin Wang 3 Xiaohua Zhang and Shandong Provincial Hospital Affiliated to University, Jinan, P.R. China Department of Neurobiology, Key Laboratory Medical School Medicine, Shandong, Tengzhou Municipal Traditional Chinese Tengzhou, Correspondence to: Wang, email: Wangxin20120916@163.com Keywords: CD300A; PECAM1; ADCY7; acute myeloid leukemia; U937 Received: August 24, 2017 Accepted: December 01, Epub: January 11, 2018 Published: June 08, ABSTRACT CD300A is a...
To date, the relationship between conjunctivitis and air pollutants has been widely concerned, but conclusions are not very unified. This study aims to explore short-term effects of ambient ozone (O3) on outpatient visits in Pudong New Area, Shanghai. A quasi-Poisson model combined with distributed lag nonlinear (DLNM) was performed O3 risk for conjunctivitis, after controlling temperature, relative humidity wind speed. Taking median concentration as a reference, moderate high (75th...
The ion funnel has proven to be an important transport device. It is used in mass spectrometry as a replacement for the transmission limited skimmer. However, conventional out-of-phase radiofrequency (RF) supply approaches inevitably produce potential barriers, decreasing efficiency. A novel RF method proposed that produces better performance.We designed driven by phase-modulated rectangular wave (PMRW). field distributions of PMRW and were computer simulated evaluate their focusing...
The rectilinear ion trap (RIT) has gradually become one of the preferred mass analyzers for portable spectrometers because its simple configuration. In order to enhance performance, including sensitivity, quantitation capability, throughput, and resolution, a novel RIT spectrometer with dual pressure chambers was designed characterized. studied system constituted quadrupole linear (QLIT) in first chamber second chamber. Two control modes are hereby proposed: Storage Quadrupole Linear Ion...
Abstract Mitochondria play a key role in the cerebral ischemia-reperfusion injury. Although extracellular signal-regulated kinase 1/2 inhibitor PD98059 (PD) is selective and reversible flavonoid that can protect mitochondria rat model of cardiac arrest/cardiopulmonary resuscitation, its requires further confirmation. In this study, we investigated whether PD could maintain mitochondrial homeostasis decrease reactive oxygen species (ROS) production neuroblastoma (SH-SY5Y) cells exposed to...