A5052176348- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Cardiac electrophysiology and arrhythmias
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroinflammation and Neurodegeneration Mechanisms
- Mechanical Circulatory Support Devices
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Angiogenesis and VEGF in Cancer
- Seaweed-derived Bioactive Compounds
- Tea Polyphenols and Effects
- Anesthesia and Neurotoxicity Research
- Restraint-Related Deaths
- Acute Myocardial Infarction Research
- Respiratory Support and Mechanisms
- RNA regulation and disease
- Heart Failure Treatment and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Flavonoids in Medical Research
Shanghai University of Traditional Chinese Medicine
2024
Shuguang Hospital
2024
Guangxi Medical University
2013-2023
Affiliated Zhongshan Hospital of Dalian University
2019
Guangxi University
2013
First Affiliated Hospital of GuangXi Medical University
2007-2011
Red Cross Hospital
1999
The clinical and experimental postcardiac arrest treatment has not reached therapeutic success. present study investigated the effect of PD98059 (PD) in rats subjected to cardiac (CA)/cardiopulmonary resuscitation (CPR). Experimental were divided randomly into 3 groups: sham, CA, PD. except for sham group CA 5 min followed by CPR operation. Once spontaneous circulation was restored, saline PD injected groups, respectively. survival rates neurologic deficit scores (NDS) observed, following...
Cerebral ischemia-reperfusion injury (CIRI) is the main cause leading to high mortality and neurological disability in patients with cardiac arrest/cardiopulmonary resuscitation (CA/CPR). Our previous study found that extracellular signal-regulated kinase (ERK) activation, dynamin-related protein1 (Drp1)/Mitofusin2 (Mfn2)-dependent mitochondrial dynamics imbalance, excessive autophagy were involved mechanism of nerve after CA/CPR. However, specific pathological signaling pathway still...
Background. In cardiac accident/cardiopulmonary resuscitation (CA/CPR) rat model, oxidative stress occurs during cerebral ischemia/reperfusion injury (CIRI), and antioxidative treatment has a neuroprotective effect. The antioxidant capabilities of pomelo peel essential oil (PPEO) have mostly been investigated in vitro, with little convincing data vivo, particularly whether PPEO role against CIRI. Methods. this investigation, CA/CPR SD model an oxygen-glucose deprivation/reperfusion (OGD/R)...
Purpose: To determine the risk factors, clinical characteristics, and prognosis of adolescent non-puerperal mastitis patients. Patients methods: A retrospective analysis was conducted on 10 cases NPM in adolescents who underwent surgical treatment at Shuguang Hospital affiliated to Shanghai University Traditional Chinese Medicine from August 2021 2023. We analyze patient’s general information, related medical history, laboratory indicators, breast magnetic resonance imaging examination,...
Some in vitro studies have identified an antithrombotic effect of polysaccharides from Laminaria japonica , but this activity remains to be confirmed vivo . In study a polysaccharide fraction termed PLG was extracted L. the Beibu Gulf Guangxi, China, and its effects explored rat models carotid venous thrombosis. Its anticoagulation antiplatelet properties were assessed by measuring prothrombin time (PT), activated partial thromboplastin (APTT) ADP‐induced platelet aggregation rate (Agg max...
Various and opposite roles of epigallocatechin gallate (EGCG) have been reported in different studies. We aimed to investigate how EGCG affects the cerebral injury a cardiac arrest/cardiopulmonary resuscitation (CA/CPR) model rat.The rats which were subjected CA/CPR randomly received low dose (3 mg/kg, Low-EGCG group, n=16), high (9 High-EGCG n=16) equal volume 0.9% saline solution (NS at first minute after return spontaneous circulation (ROSC). The underwent anesthesia intubation defined as...
Background . Reducing cerebral ischemia-reperfusion injury is crucial for improving survival and neurologic outcomes after cardiac arrest/cardiopulmonary resuscitation (CA/CPR). The purpose of this study to investigate the neuroprotective effects green tea polyphenols (GTPs) concern with modulation endogenous antioxidation endoplasmic reticulum stress. Methods After subjecting CA/CPR, rats were randomized into saline group (NS, n = 40) GTPs (GTPs, 40). Each was blindly located four subgroups...
Background: It is not known whether naloxone as efficacious epinephrine during cardiopulmonary resuscitation (CPR). The aim of the study was to compare effects and on outcomes CPR following asphyxial cardiac arrest in rats. Methods: Cardiac induced with asphyxia by clamping tracheal tubes. Twenty‐four Sprague–Dawley rats were randomized prospectively into a saline group (treated normal saline, 1 ml intravenously, n = 8), an epinephrine, 0.04 mg/kg 8) or naloxone, blind fashion after arrest....
The anti-apoptotic effect of an increase in the extracellular concentration potassium ([K+]) has been confirmed vitro. However, it is not yet known whether elevated serum [K+] exerts a cerebroprotective vivo. In this study, we aimed to explore rat model middle cerebral artery occlusion and reperfusion (MCAO/R).Rats subjected 90-min MCAO received 2.5% KCL, 1.25% or normal saline solution at dose 3.2 mL/kg onset reperfusion. Rats that were vascular exposure ligation without defined as Sham...
Pomelo peel oil (PPO) [Citrus maxima (Burm.) Merr. (Rutaceae)] is reported to possess antioxidant and antimelanogenic activities.To investigate the effect of PPO cv. Shatian Yu] on tumour necrosis factor-α (TNF-α)-induced necroptosis in cerebral ischaemia-reperfusion injury (CIRI) after cardiac arrest (CA).Male Sprague Dawley rats were randomly assigned six groups: sham group, PP0-L (10 mg/kg), PPO-M (20 PPO-H (40 mg/kg) two control groups (CA, 0.9% saline; Gly, 10% glycerol). All drugs...
The NLR family pyrin domain‑containing 3 (NLRP3) inflammasome, which is composed of NLRP3, apoptosis‑associated speck‑like protein containing a CARD (ASC) and pro‑caspase‑1 complexes, activated by the reactive oxygen species (ROS) that are associated with ischemia‑reperfusion (I/R) involved in brain damage. Pomelo peel oil (PPO) exhibits antioxidant activity. However, it unclear whether PPO able to attenuate NLRP3 inflammasome‑induced inflammation pyroptosis. Healthy male Sprague‑Dawley rats...