A5016158133- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Connective tissue disorders research
- RNA regulation and disease
- melanin and skin pigmentation
- Inflammasome and immune disorders
- Eicosanoids and Hypertension Pharmacology
- Cleft Lip and Palate Research
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Folate and B Vitamins Research
- Mast cells and histamine
- Cytokine Signaling Pathways and Interactions
- COVID-19 and Mental Health
- Fetal and Pediatric Neurological Disorders
- Craniofacial Disorders and Treatments
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Herpesvirus Infections and Treatments
- Blood Pressure and Hypertension Studies
- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
Jinzhou Medical University
2025
Anhui Medical University
2006-2024
First Affiliated Hospital of Anhui Medical University
2019-2024
Jiangnan University
2023-2024
Wuxi Fourth People's Hospital
2023-2024
Anhui Provincial Hospital
2021-2023
The First People's Hospital of Tianmen
2022
Chinese Academy of Sciences
2016-2021
Kunming Institute of Zoology
2016-2021
China Medical University
2012-2015
To determine the health-related quality of life (HRQoL) COVID-19 patients after discharge and its predicting factors.COVID-19 has caused a worldwide pandemic led huge impact on health human daily life. It been demonstrated that physical psychological conditions hospitalised are impaired, but studies focus from hospital rare.A multicentre follow-up study.This was study who had discharged six designated hospitals. Physical symptoms HRQoL were surveyed at first (the third month discharge). The...
•NCP is characterized by GGO and consolidation in the subpleural area.•Pleural effusions mediastinal lymphadenopathy are rare COVID-19 patients.•CT shows abnormal some patients with negative nucleic acid or laboratory tests. AIMTo investigate characteristics clinical value of chest computed tomography (CT) images novel coronavirus pneumonia (NCP).MATERIALS AND METHODSClinical data CT 80 cases NCP were collected. The manifestations test results analysed. lesions each lung segment patient's...
Abstract CaMK4 has an important function in autoimmune diseases, and the contribution of psoriasis remains obscure. Here, we show that expression is significantly increased psoriatic lesional skin from patients compared to healthy human as well inflamed imiquimod (IMQ)-induced mouse model skin. Camk4 -deficient ( −/− ) mice treated with IMQ exhibit reduced severity wild-type (WT) mice. There are more macrophages fewer IL-17A + γδ TCR cells IMQ-treated WT inhibits IL-10 production by...
Pathogen invasion triggers a number of cellular responses and alters the host transcriptome. Here we report that type changes to transcriptome is related functions affected by lytic infection Herpes Simplex Virus I in Human primary fibroblasts. Specifically, genes involved stress nuclear transport exhibited mostly alternative polyadenylation (APA), cell cycle showed splicing (AS) changes, while neurogenesis, rarely underwent these changes. Transcriptome wide, resulted 1,032 cases AS, 161...
Abstract Cutaneous sympathetic nerve is a crucial part of neuropsychiatric factors contributing to skin immune response, but its role in the psoriasis pathogenesis remains unclear. It found that cutaneous calcium/calmodulin‐dependent protein kinase II‐γ (CAMK2γ), expressed mainly nerves, activated by stress and imiquimod mouse skin. Camk2g ‐deficient mice exhibits attenuated imiquimod‐induced psoriasis‐like manifestations inflammation. CaMK2γ regulates dermal γδT‐cell interleukin‐17...
The ureido moiety stands as one of the most regarded scaffolds in medicinal and organic synthesis. In this study, we endeavored to synthesize a product containing tertiary amine moieties through nucleophilic substitution reaction 2-chloroethyl urea derivative with secondary amine, utilizing either inorganic bases, such K₂CO₃ or bases like triethylamine acidbinding agents diverse media. Unfortunately, failed yield desired high yield, attributed reactivity derivative. structures potential...
Background It has been shown that a deletion in the late cornified envelope (LCE) gene cluster (LCE3C_LCE3B‐del) is associated with susceptibility to psoriasis European populations. However, relationship remains unclear northern Chinese population. Objectives The aim of present study was clarify this association Methods In total, 970 patients and 1064 healthy controls were recruited polymerase chain reaction assay used determine frequency deletion. effect on assessed using SPSS software...
Non‐alcoholic fatty liver disease ( NAFLD ) is the most common cause of chronic disease, resulting not only in dysfunction, glucose and lipid metabolism disorder, but also neuropsychiatric damage. In present study, a rat model was established via feeding high‐fat diet, behaviour observed open field test OFT ), sucrose preference SPT elevated plus maze EPM forced swimming FST Morris water MWM ). The plasma concentrations alanine aminotransferase ALT glucose, free acid FFA total cholesterol TC...
Emetine, an isoquinoline alkaloid that is enriched at high concentrations in the lung, has shown potent vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim of this study was to better understand effectiveness low-dose emetine for patients with disease 2019 (COVID-19).In real-world study, 63 mild or common COVID-19 were recruited from Wuhan Fangcang Shelter Hospital and five COVID-19-designated hospitals Anhui Province, China February March 2020....
Abstract Background Dyschromatosis universalis hereditaria (DUH) is a pigmentary dermatosis characterized by generalized mottled macules with hypopigmention and hyperpigmention. ABCB6 SASH1 are recently reported pathogenic genes related to DUH, the aim of this study was identify causative mutations in Chinese family DUH. Methods Sanger sequencing performed investigate clinical manifestation molecular genetic basis these familial cases bioinformatics tools multiple sequence alignment were...
Progressive pseudorheumatoid dysplasia (PPD) is a rare autosomal recessive genetic disease, which caused by the functional loss or abnormality of Wntl-inducible signaling pathway protein 3 [WISP3 (also termed CCN6, OMIM #603400)]. WISP3 member cysteine-rich 61/connective tissue growth factor/nephroblastoma overexpressed family. Mutations in may result continuous degeneration and articular cartilage. The present study collected clinical data from three patients with PPD unrelated families,...
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial birth malformations in humans and generally classified as nonsyndromic cleft lip with or without palate (NSCL/P) only (NSCPO). Genome-wide association studies (GWASs) of NSOFCs have demonstrated multiple risk loci candidate genes; however, published factors able to explain a small fraction observed heritability.Here, we performed GWASs 1615 NSCPO cases 2340 controls, then conducted genome-wide meta-analyses NSOFCs,...
Nifedipine GITS has diuretic and natriuretic properties, which may enhance its antihypertensive efficacy. We assessed contributions of polymorphisms in the urea transporter-A gene (SLC14A2) to interindividual variations blood pressure (BP) response nifedipine treatment. 405 subjects from a single Chinese county received oral dose 30 mg (gastrointestinal therapeutic system) daily for 16 days. genotyped two SNPs SLC14A2 found significant associations Val227Ile (rs1123617) Ala357Thr (rs3745009)...
Abstract Background Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus. Cohesin, major constituent of interphase mitotic chromosomes comprised SMC1, SMC3, SCC1 (Mcd1/Rad21), SCC3 (SA1/SA2), have diverse functions, including sister chromatid cohesion, breaks repair, transcriptional control. Little known about role cohesin HSV-1 lytic infection. Methods We measured effect on...
The important role of MHC in the pathogenesis vitiligo and SLE has been confirmed various populations. To map most significant variants associated with risk SLE, we conducted fine mapping analysis using 1117 cases, 1046 cases 1693 healthy control subjects Han-MHC reference panel 1000 Genomes Project phase 3. rs113465897 (P=1.03×10 -13 , OR=1.64, 95%CI =1.44–1.87) rs3129898 (P=4.21×10 -17 OR=1.93, 95%CI=1.66–2.25) were identified as being strongly respectively. Stepwise conditional revealed...
Our previous study demonstrated that the CYP2C9*3 gene variant was significantly associated with elevated plasma irbesartan concentration and blood pressure decline, assessed by a 4-week follow-up revisit following daily administration of irbesartan. We conducted further analysis to examine acute effects CYP2C9 polymorphism on through remeasurement 6 h after used an extreme-sampling approach selecting individuals from top bottom deciles response residuals population in Anhui, Taihu, Dongzhi...
Structural variations (SVs; defined as DNA variants ≥ 50 base pairs) have been associated with various complex human diseases. However, research to screen the whole genome for SVs predisposing psoriasis is lacking.To investigate association of and psoriasis.Using imputation, we performed a genome-wide on five independent cohorts 45 386 participants from Han Chinese population. Fine-mapping analysis, genetic interaction analysis RNA expression were conducted explore mechanism SVs.In total,...
The aim of this study was to determine whether specific single nucleotide polymorphisms (SNPs) and their reconstructed haplotypes in renin-angiotensin-aldosterone system (RAAS) genes were associated with antihypertensive reduction irbesartan treatment. Thousand one forty-two hypertensives recruited received 150 mg daily for 4 weeks. Blood pressures (BPs) blood samples, at postdose on the 28th day, measured. Predose BPs plasma concentrations also Involved SNPs RAAS pathway genotyped. Genotype...