A5101469259- Reconstructive Surgery and Microvascular Techniques
- Acute Myeloid Leukemia Research
- Reconstructive Facial Surgery Techniques
- Hepatitis B Virus Studies
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Cervical Cancer and HPV Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Molecular Biology Techniques and Applications
- Immunodeficiency and Autoimmune Disorders
- Liver physiology and pathology
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
Capital Medical University
2015-2024
Chongqing University
2024
Soochow University
2010-2024
First Affiliated Hospital of Soochow University
2010-2024
Jining Medical University
2017-2024
The First People's Hospital of Guiyang
2011-2023
Nanjing University of Chinese Medicine
2023
Zunyi Medical University
2022
UCLouvain
2022
Affiliated Hospital of Jining Medical University
2018-2020
Healthy Kupffer cell (KC) pool is dominated by embryonic KCs (EmKCs), preserving liver homeostasis. How the KC varies upon injury remains unclear. Using chimeric mice with bone marrow (BM) cells labeled enhanced green fluorescent protein, we identify that BM monocyte-derived (MoKCs) become dominant in cholestatic- or toxic-injured livers via immunofluorescence and mass cytometry. Single-cell RNA sequencing (scRNA-seq) unveils proliferative, anti-apoptotic properties repair potential of MoKCs...
Background and Aims: Liver HCC is the second leading cause of cancer-related deaths worldwide. The heterogeneity this malignancy driven by a wide range genetic alterations, to lack effective therapeutic options. In study, we conducted systematic multi-omics characterization uncover its metabolic reprogramming signature. Approach Results: Through comprehensive analysis incorporating transcriptomic, metabolomic, lipidomic investigations, identified significant changes in pathways related...
Macrophage M1/M2 polarization mediates tissue damage and inflammatory responses. Cannabinoid receptor (CB) 1 participated in liver fibrogenesis by affecting bone marrow (BM)-derived monocytes/macrophages (BMMs) activation. However, the knowledge of whether CB1 is involved BMMs remains limited. Here, we found M1 gene signatures (including CD86, MIP-1β, TNF, IL-6 iNOS) amount macrophages (CD86+ cells, gated F4/80) were significantly elevated carbon tetrachloride (CCl4) -induced mouse injured...
The incidence of nasopharyngeal carcinoma (NPC) is rare, but a certain amount mortality remains in NPC patients. Our study aimed to identify candidate genes as biomarkers for screening, diagnosis, and therapy.We investigated two microarray profile datasets GSE64634 GSE12452 screen the potential differentially expressed (DEGs) NPC. Gene ontology Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis DEGs were also performed. A protein-protein interaction (PPI) network was...
Abstract Biliary atresia (BA) is a severe inflammatory and fibrosing neonatal cholangiopathy disease characterized by progressive obstruction of extrahepatic bile ducts, resulting in cholestasis hepatic failure. Cholestasis may play an important role the fibrotic pathological processes, but its specific mechanism still unclear. Necroptosis mediated Z-DNA-binding protein 1 (ZBP1)/phosphorylated-mixed lineage kinase domain-like pseudokinase (p-MLKL) prominent pathogenic factor diseases,...
The major histocompatibility complex (MHC) is one of the most variable and gene-dense regions human genome. Most studies MHC, associated regions, focus on minor variants HLA typing, many which have been demonstrated to be with disease susceptibility metabolic pathways. However, detection in MHC region, diagnostic still lacks a coherent, standardized, cost effective high coverage protocol clinical quality reliability. In this paper, we presented such method for accurate types using...
Macrophage migration inhibitor factor (MIF), a multipotent innate immune mediator, is an upstream component of the inflammatory cascade in diseases such as liver disease. Monocyte chemoattractant protein-1 (MCP-1), highly representative chemokine, critical disease pathogenesis. We investigated role MIF regulating hepatocytic MCP-1 expression. and expression were characterized by immunochemistry, RT-PCR, ELISA, immunoblotting CCl4-treated mouse isolated hepatocytes. was primarily distributed...
High-risk HPV is clearly associated with cervical cancer. integration has been confirmed to promote carcinogenesis in the previous studies. In our study, a total of 285 DNA breakpoints and 287 RNA were collected. We analyzed characteristic samples. The results revealed that patterns samples differ significantly. FHIT , KLF5 LINC00392 hotspot genes integrated by RAD51B CASC8 CASC21 ERBB2 TP63 TEX41 RAP2B MYC Breakpoints significantly prone region INTRON (P < 0.01, Chi-squared test),...
Using a noninvasive, electro-optically based electron bunch arrival time measurement at FLASH (free laser in Hamburg) the temporal resolution of two-color pump-probe experiments has been significantly improved. The system determines relative extended ultraviolet pulse and an amplified Ti:sapphire femtosecond-laser interaction region better than 90 fs rms. In benchmarking experiment using above threshold ionization noble gases, enhancement timing by factor 4 compared to uncorrected data is obtained.
Cervical cancer is one of the most common malignant tumors in gynecology.Deploying HIVID, a cost-effective technique to detect HPV integration sites, our team had studied characteristics integrations cervical exfoliated cells.Our results indicated that both sample proportion and number gradually increased following development lesion.Meanwhile, data also revealed there were recurrent genes integrated by cells.Collectively, breakpoints highly enriched intron promoter regions.Intriguingly,...
To identify novel genetic loci associated with systemic lupus erythematosus (SLE) and to evaluate potential differences between ethnic Chinese European populations in SLE susceptibility.A new genome-wide association study (GWAS) was conducted from Jining, North China, on 1506 individuals (512 cases 994 matched healthy controls). The results were meta-analysed existing data Hong Kong, Guangzhou Central as well GWAS four cohorts of ancestry. A total 26 774 (9310 17 464 controls) included this...
Two mononuclear coordination complexes of N-(2-aminophenyl)-2-(5-methyl-1H-pyrazol-3-yl)acetamide (L1), namely [Cd(L1)2Cl2] (C1) and [Cu(L1)2(C2H5OH)2](NO3)2 (C2) one complex [Fe(L2)2(H2O)2](NO3)2·2H2O (C3), obtained after in situ oxidation L1, have been synthesized characterized spectroscopically. As revealed by single-crystal X-ray diffraction, each sphere made two heterocycles is completed either chloride anions (in C1), ethanol molecules C2) or water C3). The crystal packing analysis C1,...
Copy number variations (CNVs) have been shown to cause numerous diseases, however, their roles in human lifespan remain elusive.In this study, we investigate the association of CNVs with longevity by comparing Han Chinese genomes long-lived individuals from 90 117 years age and middle-aged 30 65.
Long non-coding RNAs (lncRNAs) are a class of with the length exceeding 200 base pairs (bps), which do not encode proteins, nevertheless, lncRNAs have many vital biological functions. A large number novel transcripts were discovered as result development high-throughput sequencing technology. Under this circumstance, computational methods for lncRNA prediction in great demand. In paper, we consider global sequence features and propose stacked ensemble learning-based method to predict from...
Hepatitis B virus (HBV) integration is closely associated with the onset and progression of tumors. This study utilized DNA 27 liver cancer samples for high-throughput Viral Integration Detection (HIVID), overarching goal detecting HBV integration. KEGG pathway analysis breakpoints was performed using ClusterProfiler software. The were annotated latest ANNOVAR We identified 775 sites detected two new hotspot genes integration, N4BP1 WASHP, along 331 genes. Furthermore, we conducted a...
Abstract Methyltransferase-like 3 (METTL3) is the key subunit of methyltransferase complex responsible for catalyzing N6-methyladenosine (m 6 A) modification on mRNA, which most prevalent post-transcriptional in eukaryotes. In this study, we utilized online databases to analyze association between METTL3 expression and various aspects tumorigenesis, including gene methylation, immunity, prognosis. Our investigation revealed that serves as a prognostic marker therapeutic target liver...