A5100436067- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Autism Spectrum Disorder Research
- Lung Cancer Treatments and Mutations
- Acupuncture Treatment Research Studies
- Medical Research and Treatments
- DNA Repair Mechanisms
- Stroke Rehabilitation and Recovery
- Cancer-related gene regulation
- Balance, Gait, and Falls Prevention
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
- Cerebral Palsy and Movement Disorders
- Epigenetics and DNA Methylation
- Animal Nutrition and Physiology
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traditional Chinese Medicine Analysis
- RNA Research and Splicing
- MicroRNA in disease regulation
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2025
Second Hospital of Shandong University
2019-2025
Nanjing Medical University
2025
Xinxiang University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Beijing Hospital
2024
Nanchang University
2024
Hunan Normal University
2011-2023
Dalian University of Technology
2023
The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles RNA N6-methyladenosine (m6A) modification tumor microenvironment (TME) cell infiltration remain unknown.We comprehensively evaluated the m6A patterns 1938 gastric cancer samples based on 21 regulators, and systematically correlated these with TME cell-infiltrating characteristics. m6Ascore was constructed to quantify individual tumors using principal component analysis...
N6-methyladenosine (m6A) is the richest modification in mammalian messenger RNAs (mRNAs), and exerts key roles many biological processes, including cancer development, whereas its prostate carcinoma (PCa) remain to be unclear. Here, we found that m6A modifications are increased PCa methyltransferase-like 3 (METTL3), but not other major genes METTL14, fat mass obesity-associated protein (FTO) AlkB homolog 5 (ALKBH5), was dysregulated gene associated with abnormal modification. In addition,...
[Purpose] This study was conducted to assess the reliability and validity of center pressure-based parameters for balance assessment. [Subjects Methods] Two hundred forty older adults were evaluated using a force platform Berg Balance Scale at 1-week intervals. The intra-class correlation coefficient Pearson used test respectively. [Results] 12 selected pressure measures satisfactory (intra-class = 0.75-0.99) between moderate good (r -0.62 -0.88). [Conclusion] Center are reliable valid in adults.
Acute myocardial infarction (AMI) has the characteristics of sudden onset, rapid progression, poor prognosis, and so on. Therefore, it is urgent to identify diagnostic prognostic biomarkers for it. Cuproptosis a new form mitochondrial respiratory-dependent cell death. However, studies are limited on clinical significance cuproptosis-related genes (CRGs) in AMI. In this study, we systematically assessed genetic alterations CRGs AMI by bioinformatics approach. The results showed that six...
The incidence of nasopharyngeal carcinoma (NPC) is rare, but a certain amount mortality remains in NPC patients. Our study aimed to identify candidate genes as biomarkers for screening, diagnosis, and therapy.We investigated two microarray profile datasets GSE64634 GSE12452 screen the potential differentially expressed (DEGs) NPC. Gene ontology Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis DEGs were also performed. A protein-protein interaction (PPI) network was...
Abstract Background In modern animal husbandry, breeders pay increasing attention to improving sow nutrition during pregnancy and lactation favor the health of neonates. Sow milk is a main food source for piglets their first three weeks life, which not only rich repository essential nutrients broad range bioactive compounds, but also an indispensable commensal bacteria. Maternal microorganisms are important sources bacteria neonatal gut. Bacteria from maternal may confer benefit on host....
Abstract The transition from liver fibrosis to hepatocellular carcinoma ( HCC ) has been suggested be a continuous and developmental pathological process. Micro RNA s (mi s) are recently discovered molecules that regulate the expression of genes involved in disease. Many reports demonstrate miR‐483‐5p miR‐483‐3p, which originate miR‐483, up‐regulated , their oncogenic targets have identified. However, recent studies miR‐483‐5p/3p is partially down‐regulated samples rat fibrosis. Therefore,...
Abstract Vitamin A (VA) is an important nutrient for weaning piglets. It plays a significant role in the normal formation, development, and maintenance of epithelial cells. Previous studies have shown that VA supplements could improve host’s intestinal barrier function. Therefore, we hypothesized can affect function weaned piglets by regulating stem Thirty-two 21-d-old [(Yorkshire × Landrace) Duroc] with average weight 8.34 ± 0.13 kg were randomly divided into 4 treatment groups, 1) 2 mg/kg...
The aim of this study was to examine the prognostic value BRCA1, RRM1, and RRM2 in patients with non-small cell lung cancer (NSCLC) who received adjuvant chemotherapy. A total 418 underwent curative pulmonary resection were obtained between January 2007 November 2009. relative cDNA quantification for conducted using a fluorescence-based, real-time detection method, β-actin used as reference gene. low expression RRM1 significantly increased platinum-based chemotherapy response (For RRM1: odds...
Abstract Vitamin B6 (VB6) is an important coenzyme factor which participates in many metabolic reactions, especially amino acid metabolism. There are few reports on how VB6 mediates weaned piglet intestinal health. This study purposed to investigate dietary effects growth, diarrhea rates, and morphology function piglets fed a high-crude protein (22% CP) diet. Eighteen 21-d-old [(Yorkshire × Landrace) Duroc] with body weights of 7.03 ± 0.15 (means SEM) kg were randomly assigned into 3...
Despite the abnormal expression of 18S rRNA m6A methyltransferase METTL5 being reported in some types human malignancies, but its effect on hepatocellular carcinoma (HCC) remains to be unclear. This study aims elucidate influences carcinogenesis and progression HCC. Expressions gene, transcript, protein, promoter methylation HCC were examined through multiple databases, c-BioPortal was used confirm genomic alterations METTL5, biological functions, target networks kinases microRNAs...
Background Diabetic foot ulcers (DFU), a frequent complication of the worldwide disease (diabetes), are primary causes amputations and early mortality. The development DFU is inseparably linked with inflammation nutrition, necessitating comprehensive evaluation their impact on risk. This study aimed to establish new predictive metric that integrated immune nutritional markers holistically assess risk development. Methods Data were sourced from NHANES, extracting participant 1999 2004....
This paper employs a difference-in-differences (DID) method based on the quasi-natural experiment of merging State Tax Bureau (STB) and Local Bureaus (LTBs) in China. Using A-share Chinese listed companies Shanghai Shenzhen, China, from 2014 to 2022 as initial research sample, it explores impact STB LTBs corporate cash holdings. The study finds that China significantly increases holdings companies, this effect is more pronounced with greater managerial power. above conclusions remain robust...
Opioid-sparing anesthesia(OSA) or opioid-free anesthesia(OFA) strategy can reduce postoperative pain, but the effect of different stratigies on pain for patients with high sensitivity remains unclear, and perioperative haemodynamic fluctuations controversial undergoing laparoscopic cholecystectomy. A total 173 scheduled elective cholecystectomy were randomly assigned into three groups: anesthesia group(Group OFA), opioid-sparing OSA) opioid-based group (Group OBA). The preoperative...
There is evidence suggesting an association between hepatitis B virus (HBV) RNA and hepatic fibrosis in treatmentnaïve chronic (CHB) patients. However, few studies have delved into the relevance HBV HBV-related cirrhosis. The purpose of this article to elucidate connection cirrhosis patients undergoing nucleos(t)ide analogs (NAs). This study included 381 Logistic regression was employed investigate variables linked development Propensity score matching used correct for confounders. In...
Allelic loss of chromosome 3p, including the 3p21.3 region, is found in 95-100% primary nasopharyngeal carcinoma (NPC) biopsies, suggesting that this region should harbor some tumor suppressor genes (TSGs) closely related to NPC development. Several TSGs located at 3p21.3, such as RASSF1A, LTF and BLU, have been demonstrated be involved LARS2 (leucyl-tRNA synthetase 2, mitochondrial) another gene 3 common eliminated region-1 (C3CER1) 3p21.3. In study, we focussed on epigenetic genetic...
Aspirin intake reduces the risk of colorectal cancer (CRC), but molecular underpinnings remain elusive. Epidermal growth factor receptor (EGFR), which is overexpressed in about 80% CRC cases, implicated etiology CRC. Here, we investigated whether aspirin can prevent by normalizing EGFR expression.Immunohistochemistry staining was performed on paraffin-embedded tissue sections from normal colon mucosa, adenomatous polyps FAP patients who were classified as regular users or nonusers. The...
2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine antifolate thiophene regioisomers of AGF94 (4) with a thienoyl side chain and three-carbon bridge lengths [AGF150 (5) AGF154 (7)] were synthesized as potential antitumor agents. These analogues inhibited proliferation Chinese hamster ovary (CHO) sublines expressing folate receptors (FRs) α or β (IC50s < 1 nM) the proton-coupled transporter (PCFT) (IC50 7 nM). Compounds 5 KB, IGROV1, SKOV3 human tumor cells at subnanomolar concentrations,...
Notoginseng leaf triterpenes (PNGL) is believed to have neuroprotective effects via the inhibition of inflammatory response and neuronal apoptosis. However, its mechanisms underlying anti-ischemia/reperfusion (I/R) injury on regulation small molecule metabolism in rat brain remains unclear. The purpose this study was thus explore PNGL after I/R using matrix-assisted laser desorption ionization-mass spectrometry imaging (MALDI-MSI). As a model vivo cerebral injury, male Sprague-Dawley (SD)...
Abstract Folate is increasingly thought to promote gastrointestinal health and regulate the diversity of gut microbiota alleviate weaning stress in piglets. The present study was conducted investigate effects folate on organ weight, digesta pH, short-chain fatty acids (SCFAs) concentration, intestinal weaned A total 28 piglets (6.73 ± 0.62 kg) were allocated four dietary treatments consisting a control group, 3, 9, 18 mg/kg supplementation 14-d feeding trial. results showed that fed with 9...
Abstract Targeting cancer‐specific metabolic processes is a promising therapeutic strategy. Here, this work uses compound library that directly inhibits enzymes to screen the potential targets in lung adenocarcinoma (LUAD). SHIN1, specific inhibitor of serine hydroxymethyltransferase 1/2 (SHMT1/2), has highly inhibitory effect on LUAD cells, and depends mainly overexpression SHMT2. This clarifies mitogen‐activated protein kinase 1 (MAPK1)‐mediated phosphorylation at Ser90 key mechanism...