A5100647082- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer-related gene regulation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Bone and Dental Protein Studies
- Selenium in Biological Systems
- Biochemical and Molecular Research
- Virus-based gene therapy research
- TGF-β signaling in diseases
- Neuroscience and Neuropharmacology Research
- Endoplasmic Reticulum Stress and Disease
- Wnt/β-catenin signaling in development and cancer
- Breast Cancer Treatment Studies
- Medical and Biological Ozone Research
- Lung Cancer Treatments and Mutations
- Organoselenium and organotellurium chemistry
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Health and Risk Factors
- Ion Channels and Receptors
Capital Medical University
2015-2023
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2022
Innovation Team (China)
2022
Zhengzhou University
2022
Zhejiang University
2019-2021
Xi'an Jiaotong University
2019-2021
First Affiliated Hospital of Xi'an Jiaotong University
2020
Breast Center
2020
China International Science and Technology Cooperation
2017
Duquesne University
2015-2016
Immune checkpoint inhibitors (ICIs) have been successfully used for treating melanoma and non-small cell lung cancer. However, many patients with breast cancer (BC) show low response to ICIs due the paucity of infiltrating immune cells. Pseudogenes, as a particular kind long-chain non-coding RNA, play vital roles in tumorigenesis, but their potential tumor immunology remain unclear. In this study that data from online databases, novel pseudogene HLA-DPB2 its parental gene HLA-DPB1 were...
Neddylation is a post-translational protein modification associated with cancer development. MLN4924 neddylation inhibitor currently under investigation in multiple phase I studies on various malignancies, and its clincal name Pevonedistat. It has been documented that blocks Cullins inactivates CRLs and, turn, triggers cell-cycle arrest, apoptosis, senescence autophagy many cells. In this study, we investigated the anti-tumor effect of human clear cell renal carcinoma (ccRCC). Levels both...
Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a critical role in atherosclerosis, restenosis, and hypertension. Choline exerts cardioprotective effects; however, little is known about its effects on VSMC phenotypic remodeling. Here, we investigated whether choline modulates changes explored the underlying mechanisms. Approach Results: In cultured VSMCs, promoted Nrf2 (nuclear factor erythroid 2-related 2) nuclear translocation, inducing expression HO-1 (heme oxygenase-1)...
Zinc finger protein 281 (ZNF281) has been shown to promote tumor progression. However, the underlying mechanism remains be further elucidated. In this study, ZNF281 knockdown increased expression of mitochondrial transcription factor A (TFAM) in hepatocellular carcinoma (HCC) cells, accompanied with increment content, oxygen consumption rate (OCR) and levels TCA cycle intermetabolites. Mechanistic investigation revealed that suppressed TFAM, nuclear respiratory 1 (NRF1) peroxisome...
To identify a glycolysis-related gene signature for the evaluation of prognosis in patients with breast cancer, we analyzed data training set from TCGA database and four validation cohorts GEO ICGC databases which included 1,632 cancer. We conducted GSEA, univariate Cox regression, LASSO, multiple regression analysis. Finally, an 11 - related to glycolysis predicting survival cancer was developed. And Kaplan–Meier analysis ROC analyses suggested that showed good prognostic ability BC TCGA,...
Ovarian cancer (OV) is deemed the most lethal gynecological in women. The aim of this study was to construct an effective gene prognostic model for predicting overall survival (OS) patients with OV.The expression profiles glycolysis-related genes (GRGs) and clinical data OV were extracted from Cancer Genome Atlas (TCGA) database. Univariate, multivariate, least absolute shrinkage selection operator Cox regression analyses conducted, a signature based on GRGs constructed. predictive ability...
2-Amino-4-oxo-6-substituted-pyrrolo[2,3-d]pyrimidine antifolate thiophene regioisomers of AGF94 (4) with a thienoyl side chain and three-carbon bridge lengths [AGF150 (5) AGF154 (7)] were synthesized as potential antitumor agents. These analogues inhibited proliferation Chinese hamster ovary (CHO) sublines expressing folate receptors (FRs) α or β (IC50s < 1 nM) the proton-coupled transporter (PCFT) (IC50 7 nM). Compounds 5 KB, IGROV1, SKOV3 human tumor cells at subnanomolar concentrations,...
Glioma is the most common tumor of central nervous system; variation in susceptibility and prognosis worldwide suggests that there are molecular genetic differences among individuals. The H19 gene plays a dual role carcinogenesis. In this study, associations between polymorphisms as well glioma were evaluated. total, 605 patients with 1,300 cancer-free subjects enrolled study. Individuals rs3741219 A>G allele less likely to develop (relative risk [RR] = 0.54, 95% confidence interval [95% CI]...
Adjuvant chemotherapy remains the only recommended treatment for patients with triple-negative breast cancer (TNBC). However, existing evidence is not enough to recommend adjuvant therapies T1 N0 M0 TNBC.To evaluate association of different survival outcome in TNBC stratified by stage and age.Postoperative diagnosed as having between 2010 2015 who were enrolled Surveillance, Epidemiology, End Results registry program included this population-based cohort study. Data analysis was performed...
The actin cytoskeleton is composed of a highly dynamic network filamentous proteins, yet the molecular mechanism that regulates its organization and remodeling remains elusive. In this study, Na(+)/H(+) exchanger regulatory factor (NHERF)-1 loss-of-function gain-of-function experiments reveal polymerized (F-actin) in HeLa cells disorganized by NHERF1, whereas protein expression levels exhibit no detectable change. To elucidate underlying disorganization combined 2-dimensional...
Pemetrexed (PMX) is a 5-substituted pyrrolo[2,3-<i>d</i>]pyrimidine antifolate used for therapy of nonsquamous nonsmall cell lung cancer (NS-NSCLC). PMX transported by the reduced folate carrier (RFC) and proton-coupled transporter (PCFT). Unlike RFC, PCFT active at acidic pH levels characterizing tumor microenvironment. By real-time reverse-transcription polymerase chain reaction (RT-PCR) immunohistochemistry, transcripts proteins were detected in primary NS-NSCLC specimens. In six lines...
Increased cell mobility is a signature when tumor cells undergo epithelial-to-mesenchymal transition. TGF-β key stimulating factor to promote the transcription of variety downstream genes accelerate cancer progression and metastasis, including osteopontin (OPN) which exists in several functional forms as different splicing variants. In non-small lung cells, although increased total OPN expression was observed under various EMT conditions, exact constitution underlining mechanism towards...
Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge be resolved for the improvement of patient outcomes. It is recognized that variety secretory proteins released from tumor cells exposed chemo-drugs into microenvironment (TME) contributed cell-to-cell communication, altered drug sensitivity. One these important factors osteopontin (OPN), which exists several functional forms alternative splicing post-translational processing. In...
Previous studies of correlations microRNA (miR)-499 rs3746444 and miR-196a-2 rs11614913 polymorphisms with glioma risk have yielded inconsistent results. In this study, relationships between these two survival were evaluated. total, 605 patients 1,300 controls genotyped. increased in five genetic models (GA versus AA, odds ratio [OR], 95% confidence interval [CI] = 1.31 [1.05-1.66], p 0.02; GG OR [95% CI] 10.70 [6.13-18.69], < 0.0001; GA + 1.82 [1.47-2.24], AA GA, 9.99 [5.74-17.40], G A,...
The treatment for locally advanced breast cancer (LABC) is a severe clinical problem. postoperative radiotherapy conventional method patients with LABC, whereas the effect of preoperative on outcome LABC remains controversial. This study aimed to examine and compare overall survival (OS) in who underwent or radiotherapy.This retrospective cohort included 41,618 from National Cancer Database (NCDB) between 2010 2014. We collected patients' demographic, clinicopathologic, information....
To investigate the involvement and transcriptional targets of zinc finger protein 281 (ZNF281) in progression hepatocellular carcinoma (HCC).The expression ZNF281 HCC was detected tissue microarray cell lines. The role aggressiveness examined using wound healing, matrigel transwell, pulmonary metastasis model assays for EMT markers. RNA-seq used to find potential target gene ZNF281. Chromatin immunoprecipitation (ChIP) assay co-immunoprecipitation (Co-IP) were employed uncover mechanism...
To determine the antitumor activities and molecular mechanism of selenium compounds in HeLa cells.Western blotting was used to detect ERK AKT activation cells induced by selenomethionine (SeMet), methylselenocysteine (MeSeCys) methylseleninic acids (MeSeA). Using MTT, wound-healing Matrigel adhesion assays, effects SAM were evaluated cells.MeSeA inhibited signaling pathways suppressed proliferation (p<0.05 vs. control), migration control) (p<0.01 cells. MeSeCys SeMet The synergistic action...