A5101732712- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Mesenchymal stem cell research
- RNA modifications and cancer
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Parasites and Host Interactions
- Bone and Joint Diseases
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- interferon and immune responses
- Leptospirosis research and findings
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
Guiyang Medical University
2019-2025
Affiliated Hospital of Guizhou Medical University
2019-2025
Tsinghua University
2003-2025
Lianyungang Oriental Hospital
2024
Zhengzhou University
2014-2021
Henan Cancer Hospital
2016-2021
National Health and Family Planning Commission
2021
Wuhan Children's Hospital
2021
Huazhong University of Science and Technology
2021
Soochow University
2019-2020
T follicular regulatory (Tfr) cells are a new subset of (T reg) localized in the germinal center to limit humoral response. Until now, physiological function Tfr has been largely unknown. In this study, we developed Bcl6fl/flFoxp3Cre mouse analyze immune and autoimmune responses. These mice exhibited enhanced immunity influenza virus; moreover, Bcl6fl/flFoxp3Cre/Cre late-onset spontaneous diseases, affecting salivary glands with lymphocyte infiltration antibody deposition. experimental...
Transcription coactivator Yes-associated protein (YAP) plays an important role in the regulation of cell proliferation and apoptosis. Here, we identify a new YAP cellular senescence. We find that expression levels proteins decrease following replication-induced senescence IMR90 cells. Silencing inhibits induces premature In additional experiments, observe induced by deficiency is TEAD- Rb/p16/p53-dependent. Furthermore, show Cdk6 direct downstream target gene senescence, through YAP-TEAD...
C3H/HeN mice infected intravenously with a dose of Rickettsia conorii (Malish 7 strain) that is sublethal for immunocompetent animals (1.1 x 10(3) PFU) developed disseminated infection endothelial cells the brain, lungs, heart, liver, kidney, testis, and testicular adnexa. In R. conorii-infected depleted gamma interferon (IFN-gamma) and/or tumor necrosis factor alpha (TNF-alpha) by intravenous administration neutralizing monoclonal antibodies on days 0, 2, 4, mortality rate was 100%. Death...
T cell activation is accompanied by extensive changes in epigenome. However, the high-ordered chromatin organization underpinning CD8+ not fully known. Here, we show three-dimensional genome during activation, associated with gene transcription. We that T-cell-specific deletion of Trim28 mice disrupts autocrine IL-2 production and leads to impaired vitro vivo. Mechanistically, TRIM28 binds regulatory regions genes formation chromosomal loops activation. At loop anchor regions,...
Tumor infiltrating lymphocyte therapy (TIL therapy) is one of the effective treatments for solid tumors. However, certain periods or sites tumors are not amenable to surgical resection. Meanwhile, abundant and dense extracellular matrix (ECM) regulatory cells (e.g., T (Tregs), myeloid-derived suppressor (MDSC)) in when infused back into treatment will prevent cell infiltration proliferation, thus inhibiting efficacy this approach. In study, a novel preparation was successfully developed by...
To evaluate the roles of CD4 and CD8 T lymphocytes in immunity to disseminated endothelial infection with Rickettsia conorii (Malish 7 strain), these cell subsets were depleted or adoptively transferred into subsequently infected C3H/HeN mice. lymphocyte-depleted sham-depleted mice underwent a similar course illness sublethal rickettsial dose, cleared by day 10, recovered on days 10 11. In contrast, died remained persistently through 15 ordinarily dose. Endothelium was major site...
Abstracts Glycine decarboxylase (GLDC) belongs to the glycine cleavage system and is involved in one-carbon metabolism. We previously reported that GLDC downregulation enhances hepatocellular carcinoma (HCC) progression intrahepatic metastasis through decreasing ROS-mediated ubiquitination of cofilin. The role autophagy cancer still controversial. Redox-dependent largely relies on magnitude rate ROS generation. Thus, we aimed explore cellular during HCC progression. showed a high expression...
Rickettsia akari was isolated from blood collected a patient in Croatia 1991. We believe this is the first human isolate of R. to be reported more than 40 years and ever southern Europe. The Croatian antigenically genetically indistinguishable prototype American strain Ukrainian strain. In all probability, rickettsialpox would diagnosed frequently over wider geographic area if physicians gave greater consideration diagnosis laboratory diagnostic methods were better able distinguish among...
Paeoniflorin exhibits anticancer, anti-inflammatory and antioxidation effects, as well specific pharmacological effects on smooth muscle the immune, cardiovascular central nervous systems. The present study aimed to investigate anticancer of paeoniflorin pancreatic cancer cells elucidate mechanisms by which these occur. In study, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide lactate dehydrogenase assays were performed assess cell viability cytotoxicity BXPC-3 human cells,...
Abstract Interleukin 32 (IL32) is a pro-inflammatory cytokine that plays key role in promoting sterile inflammation by modulating immune responses. However, the of IL32 various cancers remains unclear. This research aimed to investigate correlation between expression and immunity visualize its prognostic landscape pan-cancer. We investigated gene expression, genomic alterations, survival analysis pan-cancer numerous databases including TCGA, GTEx, cBioPortal, GDC databases. Tumor cell...
The role of Ras guanine nucleotide-releasing protein 1 (RasGRP1) in tumourigenesis has been a subject debate, and its functions clinical significance hepatocellular carcinoma (HCC) remain unknown. Here, we evaluated the expression RasGRP1 HCC determined how it contributes to cell proliferation.RasGRP1 was measured by quantitative polymerase chain reaction (qPCR) Western blotting 24 paired tissues para-tumour tissues. confirmed immunohistochemical analysis tissue microarray from independent...
To detect the aberrantly expressed long non-coding RNAs in glioblastoma, two pairs of glioblastoma and adjacent normal tissues were firstly analyzed by RNA sequencing. Long intergenic LINC00657 was considered to play a vital role based on results Hence, we aimed investigate mechanisms which regulated tumorigenesis glioblastoma. The level 40 samples cell lines detected RT-qPCR. significantly decreased patients with compared tissues. Overexpression inhibited proliferation, colony formation,...
Abstract Mice made neonatally tolerant to alloantigens were found develop an immunologic disease resembling systemic lupus erythematosus. In BALB/c mice injected with C57BL/6 X F1 hybrid spleen cells, features of autoimmunity observed first. After 5-24 wk, antinuclear, anti-SS DNA, thymocytotoxic, and rheumatoid factor-like antibodies detected in association hypergammaglobulinemia the occurrence circulating immune complexes cryoglobulins. Some antinuclear be produced by donor B cells...
T follicular helper (Tfh) cells, essential for germinal center reactions, are not identical, with different phenotypes reported. Whether, when, and how they generate memory cells is still poorly understood. Here, through single-cell RNA-sequencing analysis of CXCR5+Bcl6+ Tfh generated under conditions, we discovered, in addition to PD-1hi effector a CD62L+PD1low subpopulation. CD62L-expressing developed independently from PD-1+ direct contact B cells. More importantly, CD62L+ expressed...