A5101695683- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Corneal Surgery and Treatments
- Liver physiology and pathology
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Ocular Surface and Contact Lens
- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Pancreatic function and diabetes
- Galectins and Cancer Biology
- Immune cells in cancer
- Tryptophan and brain disorders
- Gynecological conditions and treatments
- Axon Guidance and Neuronal Signaling
- interferon and immune responses
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Mesenchymal stem cell research
Guiyang Medical University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Affiliated Hospital of Guizhou Medical University
2017-2025
Xiamen Medical College
2023-2024
University of Connecticut
2014-2021
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2020
Nantong University
2017
Affiliated Hospital of Nantong University
2017
Children's Hospital of Chongqing Medical University
2015
Chongqing Medical University
2015
Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are a novel and promising strategy for tissue engineering because of their ability to differentiate into many cell types. We characterized the differentiation WJ-MSCs endometrial epithelial (EEC)-like stromal (ESC)-like assessed effect 17β-estradiol 8-Br-cAMP on system. were treated in two ways EEC-like ESC-like respectively: cocultured with ESCs control/differentiation medium (17β-estradiol, growth factors); cultured (8-Br-cAMP alone...
Abstract Thymic epithelial cells (TECs) are the major components of thymic microenvironment for T cell development. TECs derived from progenitors (TEPs). It has been reported that human ESCs (hESCs) can be directed to differentiate into TEPs in vitro . However, efficiency differentiation is low. Furthermore, transplantation hESC-TEPs mice only resulted a very low level development co-transplanted hematopoietic precursors. We show here we have developed novel protocol efficiently induce hESCs...
ABSTRACT Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease (AID) mediated by myelin‐reactive CD4 + T cells. Experimental encephalomyelitis (EAE) widely used animal model of human MS. Erythrocyte membrane‐associated protein (ERMAP) novel erythrocyte‐specific adhesion/receptor molecule associated with erythrocyte adhesion. We have previously characterised it as inhibitory immune checkpoint and demonstrated that recombinant ERMAP proteins ameliorate EAE; however, the...
Corneal neovascularization (CNV) is one of the leading causes blindness in world. In clinical practice; however, it remains a challenge to achieve noninvasive and safe treatment. Herein, biocompatible shell with excellent antioxidant antivascularity prepared by co-assembly epigallocatechin gallate/gallic acid Cu (II). After loading glucose oxidase (GOx) inside, modified dimeric DPA-Zn for codelivering vascular endothelial growth factor (VEGF) small interfering RNA (VEGF-siRNA). Meanwhile,...
We have reported that in vivo administration of the hybrid cytokine rIL-7/HGFβ or rIL-7/HGFα, which contains interleukin-7 (IL-7) and β- α-chain hepatocyte growth factor (HGF), significantly enhances thymopoiesis mice after bone marrow transplantation. shown HGF receptor, c-Met, is involved effect cytokines. To address role c-Met signalling thymocyte development recovery, we generated conditional knockout (cKO) was specifically deleted T cells by crossing c-Met(ft/ft) with CD4-Cre transgenic...
Abstract Both IL7 and IL15 have become important candidate immunomodulators for cancer treatment. However, or used alone suffers from shortcomings, such as short serum half-life limited antitumor effect. We cloned expressed a recombinant (r) IL7/IL15 fusion protein in which are linked by flexible linker. then compared the effect of rIL7/IL15 with individual factors rIL7 and/or rIL15. show here that has higher activity than combination both murine B16F10 melanoma CT-26 colon models. This was...
A prolonged period of T-cell recovery is the major challenge in hematopoietic stem cell transplantation (HSCT). Thymic epithelial cells (TECs) are component thymic microenvironment for generation. However, TECs undergo degeneration over time. FOXN1 plays a critical role TEC development and required to maintain adult thymopoiesis. To investigate potential application FOXN1, we have cloned expressed recombinant protein (rFOXN1) that was fused with cell-penetrating peptides. We show here rFOXN1...
Corneal integrity, transparency, and visual acuity are maintained by corneal epithelial cells (CECs), which continuously renewed limbal stem (LESCs). The cell deficiency is associated with ocular diseases. This study aimed to develop a novel method differentiate bone marrow mesenchymal (BM-MSCs) into LESC-like using culture medium paired box 6 (Pax6) transfection. were confirmed the LESC markers CK14 p63 CEC marker CK12. Pax6 induces BM-MSCs in vitro. Mouse models of chemical burn obtained...
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the most common cause of dementia in elderly. Although amyloid-beta (Aβ) plaque deposition chronic neuroinflammation central nervous system (CNS) contribute to AD pathology, neither Aβ removal nor anti-inflammatory therapy has shown much clinical success, suggesting that combinational therapies for disease-causative factors may be needed amelioration. Recent data also suggest systemic immunity should boosted, rather...
T cell responses are fine-tuned by co-stimulatory and co-inhibitory molecules. Among the regulators, B7 family members of central importance. The recent success in targeting molecules for treatment immune-related diseases has attracted intense interest identifying additional B7-related In this study, we describe CD300c as a novel molecule that shares significant sequence homology with existing members. protein is expressed on professional antigen-presenting cells (APC), including B cells,...
This study aimed to investigate the effects of SIRT1 modulation on heroin addiction-like behavior and its possible biological mechanisms. Wild-type C57BL/6J Sirt1 loxp/loxp D1-Cre mice were used in this experiment, D1-Cre(−) as a control for conditional knockout mice. Mice divided into saline heroin-dependent groups. Behavioral methods record withdrawal response, conditioned place preference (CPP) changes, open field test results. Transmission electron microscopy (TEM) was observe structure...
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains significant cause of late morbidity mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome. Thymic epithelial cells (TECs) play critical role in supporting negative selection regulatory T-cell (Treg) generation. Studies have shown that damage TECs sufficient to...
T cell stimulatory and inhibitory molecules are critical for the regulation of immune responses. In this study, we identify a novel co-inhibitory molecule TAPBPL, whose amino acid sequence shares homology with known B7 family members. TAPBPL protein is expressed on resting activated cells, B monocytes, dendritic cells (DCs), as well some tumor tissues. The putative receptor CD4 CD8 cells. A soluble recombinant human TAPBPL-IgG Fc (hTAPBPL-Ig) fusion inhibits proliferation, activation,...
Abstract Rheumatoid arthritis (RA) is an autoimmune disorder characterized by persistent inflammatory responses in target tissues and organs, resulting the destruction of joints. Collagen type II (CII)-induced (CIA) most used animal model for human RA. Although BTN2A2 protein has been previously shown to inhibit T cell functions vitro , its effect on not reported. In this study, we investigate ability a recombinant BTN2A2-IgG2a Fc (BTN2A2-Ig) fusion treat CIA. We show here that...
Abstract Type 1 diabetes (T1D) is a T cell‐mediated autoimmune disease in which insulin‐producing β ‐cells are destroyed. Although butyrophilin‐like 2 (BTNL2) has been shown to be negative cell regulator vitro, its ability inhibit responses vivo not determined. In this study, the effect of recombinant BTNL2‐IgG2a Fc (rBTNL2‐Ig) fusion protein on T1D development It here that administration rBTNL2‐Ig ameliorates non‐obese diabetic (NOD) mice. This associated with proliferation, activation, and...
Abstract Immune responses are tightly controlled by T cell costimulatory and coinhibitory molecules. In this study, we identify Skint8 as a new member of the group, whose extracellular domains share significant homology with existing B7 family members. mRNA is expressed in resting activated B cells, monocytes, CD4 cells. The putative receptor on CD8 monocytes dendritic Recombinant Skint8–IgG Fc fusion protein inhibits proliferation, activation, cytokine production vitro. vivo administration...
RA is a chronic autoimmune disease characterized by joint inflammation and tissue destruction. Immune responses mediated T cells autoantibodies are known to play critical roles in RA. Collagen type II (CII)-induced arthritis (CIA) commonly used animal model of human We have previously reported the identification new cell inhibitory molecule CD300c. Here we investigate ability recombinant CD300c-IgG2a Fc (CD300c-Ig) fusion protein prevent treat CIA.Mice were induced develop CIA CII injected...