A5043651820- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Virology and Viral Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Histone Deacetylase Inhibitors Research
- Pluripotent Stem Cells Research
- T-cell and Retrovirus Studies
- Cytokine Signaling Pathways and Interactions
- Herpesvirus Infections and Treatments
- Liver physiology and pathology
- Bioactive Compounds and Antitumor Agents
- Monoclonal and Polyclonal Antibodies Research
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Fungal Biology and Applications
- Transgenic Plants and Applications
- Phytochemicals and Antioxidant Activities
- Inflammation biomarkers and pathways
- Cancer Mechanisms and Therapy
China Three Gorges University
2007-2024
Jilin Agricultural University
2023
University of Connecticut
2000-2017
Huazhong University of Science and Technology
2009-2012
Macrophage polarization determines the production of cytokines that fuel initiation and evolution rheumatoid arthritis (RA). Thus, modulation macrophage might represent a potential therapeutic strategy for RA. However, coordinated macrophages in synovium synovial fluid has not been achieved thus far. Herein, we develop biomimetic ApoA-I mimetic peptide-modified neutrophil membrane-wrapped F127 polymer (R4F-NM@F127) targeted drug delivery during RA treatment. Due to high expression adhesion...
Renal ischemia/reperfusion (I/R) injury continues to be a complicated situation in clinical practice. Genistein, the main isoflavone found soy products, is known possess wide spectrum of biochemical and pharmacological activities. However, protective effect genistein on renal I/R has not been well investigated. In current study, we explore whether exhibits its renal-protective effects through SIRT1 (Sirtuin 1) I/R-induced mice model. We treatment significantly reduced cell death,...
Abstract Thymic epithelial cells (TECs) are the major components of thymic microenvironment for T cell development. TECs derived from progenitors (TEPs). It has been reported that human ESCs (hESCs) can be directed to differentiate into TEPs in vitro . However, efficiency differentiation is low. Furthermore, transplantation hESC-TEPs mice only resulted a very low level development co-transplanted hematopoietic precursors. We show here we have developed novel protocol efficiently induce hESCs...
Accurate detection of buildings is great significance for urban planning and rapid development. Using the rich scattering information contained in polarimetric SAR, relevant target features can be extracted. For covered by vegetation, penetration capability long-wavelength SAR utilized to further extract their characteristic information, enabling more effective detection. This study analyzes experimental data based on ALOS PALSAR imagery Shenzhen. The results indicate that obscured trees...
Target detection is an important part of radar image interpretation. The use SAR technology combined with deep learning network models has become means ship target detection. Compared traditional methods, powerful data processing and feature extraction capabilities. Therefore, this paper proposes a multi-scale dynamic fusion (DFS) model for based on YOLOv8. includes three parts: fusion, alignment, attention mechanism enhancement. Finally, experiments were conducted the SAR-ship dataset....
We have reported that in vivo administration of the hybrid cytokine rIL-7/HGFβ or rIL-7/HGFα, which contains interleukin-7 (IL-7) and β- α-chain hepatocyte growth factor (HGF), significantly enhances thymopoiesis mice after bone marrow transplantation. shown HGF receptor, c-Met, is involved effect cytokines. To address role c-Met signalling thymocyte development recovery, we generated conditional knockout (cKO) was specifically deleted T cells by crossing c-Met(ft/ft) with CD4-Cre transgenic...
The T-box transcriptional factor (Tbx) family of factors has distinct roles in a wide range embryonic differentiation or response pathways. Tbx1, transcription factor, is an important gene for the human congenital disorder 22q11.2 deletion syndrome. Induced pluripotent stem cell (iPSC) technology offers new opportunities both elucidation pathogenesis diseases and development stem-cell-based therapies. In this study, we generated iPSCs from Tbx1(-/-) Tbx1(+/+) fibroblasts investigated...
Abstract Both IL7 and IL15 have become important candidate immunomodulators for cancer treatment. However, or used alone suffers from shortcomings, such as short serum half-life limited antitumor effect. We cloned expressed a recombinant (r) IL7/IL15 fusion protein in which are linked by flexible linker. then compared the effect of rIL7/IL15 with individual factors rIL7 and/or rIL15. show here that has higher activity than combination both murine B16F10 melanoma CT-26 colon models. This was...
A prolonged period of T-cell recovery is the major challenge in hematopoietic stem cell transplantation (HSCT). Thymic epithelial cells (TECs) are component thymic microenvironment for generation. However, TECs undergo degeneration over time. FOXN1 plays a critical role TEC development and required to maintain adult thymopoiesis. To investigate potential application FOXN1, we have cloned expressed recombinant protein (rFOXN1) that was fused with cell-penetrating peptides. We show here rFOXN1...
Background. Human leukocyte antigen (HLA)-G, a nonclassical HLA class I molecule, induces wide range of tolerogenic immunological effects by means interaction with its inhibitory receptors. However, recent studies show that HLA-G dimer formation is essential to bind receptors and exhibit effects. Methods. In this study, soluble divalent HLA-G/IgG molecule (sHLA-G dimer) was constructed. Its effect on T-cell alloresponse studied mixed lymphocyte reaction in vitro, which set up mixing...
T cell immunodeficiency is a major complication of bone marrow (BM) transplantation (BMT). Therefore, approaches to enhance reconstitution after BMT are required. We have purified hybrid cytokine, consisting IL-7 and the β-chain hepatocyte growth factor (HGFβ) (IL-7/HGFβ), from unique long-term BM culture system. cloned expressed IL-7/HGFβ gene in which HGFβ genes connected by flexible linker generate rIL-7/HGFβ protein. Here, we show that treatment enhances thymopoiesis allogeneic BMT....
Abstract Microvesicles (MVs) are heterogeneous membrane‐bound sacs formed by direct plasma membrane budding, that have promising potential for targeted drug delivery and therapy. However, to date, they limited application lymph node (LN) targeting due their large size. Herein, the size conversion of erythrocyte‐derived MVs (eMVs) via incubation with an ApoA‐I mimetic peptide (R4F) capable binding phospholipids is performed. The interaction between R4F phospholipid bilayers eMVs limits...
Tumor necrosis factor alpha (TNF-α) is a crucial in the control of Mycobacterium tuberculosis ( Mtb ) infection. Pathogenic mycobacteria can inhibit and/or regulate host cell TNF-α production variety ways to evade antituberculosis (anti-TB) immunity as well facilitate immune escape. However, mechanisms by which expression cells modulated benefit still an interesting topic and needs further study. Here, we report that macrophages infected with marinum Mm )—a close relative —upregulated E3...
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains significant cause of late morbidity mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome. Thymic epithelial cells (TECs) play critical role in supporting negative selection regulatory T-cell (Treg) generation. Studies have shown that damage TECs sufficient to...
Selectively positioning indocyanine green in the biomimetic nanoplatform enhanced fluorescence intensity and stability for timely accurate sentinel lymph node imaging.