A5102790880- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Medical Imaging Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Cervical Cancer and HPV Research
- Pregnancy-related medical research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Endometriosis Research and Treatment
Ningxia Medical University General Hospital
2021-2025
Ningxia Medical University
2021-2025
Eye & ENT Hospital of Fudan University
2025
Shanghai University of Traditional Chinese Medicine
2019-2025
Chongqing Medical University
2024
Hubei University of Medicine
2023-2024
Taihe Hospital
2024
Second Military Medical University
2017-2024
Jiading District Central Hospital
2019-2024
Shanghai University of Medicine and Health Sciences
2019-2024
Foundational models suggest Alzheimer's disease (AD) can be diagnosed using retinal images, but the specific structural features remain poorly understood. This study investigates vascular changes in individuals with cognitive impairment three East Asian regions. A multicenter was conducted Shanghai, Hong Kong, and Ningxia, collecting images from 176 patients mild (MCI) or AD 264 controls. The VC-Net deep learning model segmented arterial/venous networks, extracting 36 features. Significant...
BACKGROUND: MicroRNAs (miRNAs) emerge as important regulators involved in malignant progression some tumors. MiR-181a has been found to function a tumor suppressor tumors including non-small cell lung cancer (NSCLC). However, the functional role of miR-181a NSCLC still needed be investigated. METHODS: The expression were determined by qRT-PCR, association between and clinicopathological data performed chi-square test survival analysis evaluated Kaplan-Meier curve log rank test. Cell...
The aim was to assess the diagnostic accuracy of four different nutrition screening and evaluation instruments in nasopharyngeal carcinoma patients, benchmarked against Global Leadership Initiative on Malnutrition (GLIM) criteria. An observational, single-institution study conducted between June 2022 May 2023. Nutrition status assessed using Nutritional Risk Screening 2002 (NRS-2002), Universal Tool (MUST), (MST), Patient-Generated Subjective Assessment (PG-SGA), GLIM criteria at two time...
The aim of the present study was to investigate early diagnostic values measuring procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (lL-6) levels in patients with bacterial infections septicopyemia. Ninety-two septicopyemia who were diagnosed treated First Affiliated Hospital Fujian Medical University between December 2012 October 2013 randomly selected. Based on results hemoculture, divided into Gram-negative infection group (n=47) Gram-positive (n=45). Immune nephelometry...
Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are a novel and promising strategy for tissue engineering because of their ability to differentiate into many cell types. We characterized the differentiation WJ-MSCs endometrial epithelial (EEC)-like stromal (ESC)-like assessed effect 17β-estradiol 8-Br-cAMP on system. were treated in two ways EEC-like ESC-like respectively: cocultured with ESCs control/differentiation medium (17β-estradiol, growth factors); cultured (8-Br-cAMP alone...
Lipusu is the first commercialized liposomal formulation of paclitaxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma (LSCC) in a small-scale study. Here, we conducted multicenter, randomized, phase 3 study to compare safety cisplatin plus (LP) versus gemcitabine (GP) as first-line treatment or metastatic LSCC.Patients enrolled were aged between 18 75 years, had (clinical stage IIIB, ineligible for concurrent chemoradiation surgery) (Stage IV)...
Colorectal cancer (CRC) is a prevalent malignancy worldwide, often treated with chemotherapy despite its limitations, including adverse effects and resistance. The traditional Chinese medicine (TCM) Jianpi formula has been demonstrated to improve efficacy of chemotherapy, however the underlying mechanisms still need be explored. In this study, we aim screen bioactive peptides derived from blood CRC patients through peptidomics explore molecular candidate in inhibition using multi-omics...
We investigated the possible role of miR-143 in development cisplatin resistance human gastric cancer cell line. was detected by quantitative real-time PCR. Cisplatin changes cells tested via MTT assay. Target genes were verified dual-luciferase activity Immunohistochemistry, immunofluorescence staining, Western blot, proliferation, and clonogenic apoptosis assay used to elucidate mechanism formation. downregulated tissues lines. It also cisplatin-resistant line SGC7901/cisplatin (DDP),...
Expression of Ki‑67 and P16 proteins in cervical cancer precancerous lesions young women the diagnostic value for were investigated. A total 64 paraffin‑embedded specimens uterus tissue from female patients who admitted to Jiading District Central Hospital Affiliated Shanghai University Medicine Health Sciences January 2015 December 2017 selected. According pathological examination, divided into chronic cervicitis group (control group, 10 cases), low‑grade squamous intraepithelial lesion...
Ovarian cancer is a multifactorial and deadly disease. Despite significant advancements in ovarian therapy, its incidence on the rise molecular mechanisms underlying invasiveness, metastasis drug resistance remain largely elusive, resulting poor prognosis. Oncolytic viruses armed with therapeutic transgenes of interest offer an attractive alternative to chemical drugs, which often face innate acquired resistance. The present study constructed novel oncolytic adenovirus carrying
The aim of this study was to investigate the predictive value early changes in 18 F-fluoroestradiol (FES) positron emission tomography (PET)/computed (CT) during fulvestrant 500 mg therapy patients with estrogen receptor (ER)-positive metastatic breast cancer.Patients underwent F-FES PET/CT scans at both baseline (scan 1) and day 28 2). maximum standardized uptake (SUVmax) all sites determined each scan, percentage reduction SUVmax (ΔSUVmax) calculated as [(SUVmax on scan 1-SUVmax 2)/ 1] *...
Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) exhibit strong and powerful potential in repairing different diseases. The expression profile of circular RNA (circRNA) provides valuable insight for regulation the repair process exploration reparative effect mechanisms. Human endometrial stromal (ESCs) were cultured with mifepristone to obtain damaged ESCs, which then cocultured or without WJ-MSCs (cocultured group versus non-cocultured group) observe upon ESCs by WJ-MSCs. CircRNA...
The oral multi-targeted tyrosine kinase inhibitor (TKI) anlotinib is effective for non-small cell lung cancer (NSCLC) in clinical trials at 3rd line. However, a fraction of patients remains nonresponsive, raising the need how to identify anlotinib-responsive patients. In present study, we aimed screen potential biomarkers stratification via integrated transcriptome analysis. Comparing with anlotinib-sensitive NCI-H1975, found 1,315 genes were differentially expressed anlotinib-resistant...
Circulating tumour DNA (ctDNA)-based sequencing might provide a simple test for the stratified model of non-small cell lung cancer (NSCLC). Here, we aimed to assess ctDNA sequencing-based mutation index (TMI) screening responders (from non-responders) among NSCLC patients who received monotherapy with docetaxel or atezolizumab.We performed retrospective analysis POPLAR (NCT01903993) and OAK (NCT02008227) trials. We identified three biomarkers, blood burden (bTMB), sensitive (sbTMB)...
Accumulating evidence indicates that mesenchymal stem cells (MSCs) exert tissue repair effects and therapeutic angiogenesis through their noncoding RNAs (ncRNAs). Our previous studies showed MSCs derived from Wharton's jelly (WJ-MSCs) can ameliorate damaged human endometrium by promoting angiogenesis. There is limited information on the functions mechanism of ncRNAs in MSC-induced endometrial repair, additional are needed for more insights. Here, WJ-MSCs were cocultured with or without...
Abstract Acetyl‐CoAacyltransferase2 (ACAA2) is a key enzyme in the fatty acid oxidation pathway that catalyzes final step of mitochondrial β oxidation, which plays an important role metabolism. The expression ACAA2 closely related to occurrence and malignant progression tumors. However, function ovarian cancer unclear. level prognostic value were analyzed by databases. Gain loss carried out explore cancer. RNA‐seq bioinformatics methods applied illustrate regulatory mechanism ACAA2....
Rationale: Platinum-based chemotherapy is one of treatment mainstay for patients with advanced lung squamous cell carcinoma (LUSC) but it still a "one-size fits all" approach. Here, we aimed to investigate the predictive and monitoring role circulating cell-free DNA (cfDNA) profiling outcome first-line in LUSC. Methods: Peripheral blood samples 155 from phase IV trial 42 cases an external real-world cohort were prospectively collected. We generated copy number variations-based classifier via...
Objective: To explore the diagnostic value of serum amyloid A (SAA) and C-reactive protein (CRP) for predicting acute aortic dissection (AAD). Methods: One hundred seventy-five AAD patients 160 with coronary syndrome (disease control group) who were admitted to Cardio-cerebrovascular Disease Hospital General Ningxia Medical University from January 2018 June 2020 retrospectively selected. Meanwhile, 148 healthy subjects (healthy underwent physical examination also enrolled. The latex-enhanced...