A5083998269- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Parathyroid Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Circular RNAs in diseases
- Congenital heart defects research
- Vascular Anomalies and Treatments
- RNA modifications and cancer
- Moyamoya disease diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Intracranial Aneurysms: Treatment and Complications
- Dermatological and Skeletal Disorders
- Hepatitis Viruses Studies and Epidemiology
- Adipose Tissue and Metabolism
- Lung Cancer Treatments and Mutations
- Liver Diseases and Immunity
- TGF-β signaling in diseases
- Peroxisome Proliferator-Activated Receptors
- RNA Interference and Gene Delivery
- Estrogen and related hormone effects
- Heterotopic Ossification and Related Conditions
- Kruppel-like factors research
- 3D Printing in Biomedical Research
University of Copenhagen
2020-2025
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Xi'an Jiaotong University
2013-2024
Tianjin University
2024
Sichuan University
2024
Foshan University
2024
University of California, Los Angeles
2013-2022
Fujian Medical University
2021-2022
The First Affiliated Hospital, Sun Yat-sen University
2021
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and irreversible lung disease. Studies have shown that epithelial-mesenchymal transition (EMT) plays an important role in the development of IPF. The NLRP3 inflammasome reported to be activated play many respiratory diseases. However, whether alveolar epithelial cells as well regulatory EMT not been reported. In this study, we transfected siRNA into A549 RLE-6TN treated them with bleomycin (BLM) for 24h. Then, detected expression...
Results from recent studies suggest that aberrant microRNA expression is common in numerous cancers. Although miR-338-3p has been implicated hepatocellular carcinoma, its role gastric cancer unknown. To this end, we report downregulated both tissue and cell lines. Forced of inhibited proliferation clonogenicity induced a G1-S arrest as well apoptosis cells. Furthermore, P-Rex2a (PREX2) was identified direct target miR-338-3p, silencing resulted the same biologic effects enforced or...
Abstract Background MicroRNAs are regulators that can play an essential role in tumorigenesis. Although miR-302 families have been suggested to be tumor repressors human cancer, the mechanism by which they suppress development remains defined. In this study, we discover miR302b suppresses proliferation may due directly targeting EGFR hepatocellular carcinoma (HCC). Methods QRT-PCR was used assess miR-302b and expression 27 pairs of clinical tissues their corresponding adjacent nontumorous...
Endothelial cells have the ability to undergo endothelial-mesenchymal transitions (EndMTs), by which they acquire a mesenchymal phenotype and stem cell-like characteristics. We previously found that EndMTs occurred in endothelium deficient matrix γ-carboxyglutamic acid protein enabling endothelial contribute vascular calcification. However, mechanism responsible for initiating is not fully understood.To determine role of specific serine proteases sex determining region Y-box 2 (Sox2)...
Abstract The mechanisms linking tumor microenvironment acidosis to disease progression are not understood. Here, we used mammary, pancreatic, and colon cancer cells show that adaptation growth at an extracellular pH (pH e ) mimicking acidic niches is associated with upregulated net acid extrusion capacity elevated intracellular physiological , but . Using metabolic profiling, shotgun lipidomics, imaging biochemical analyses, the adaptation‐induced phenotype characterized by a shift toward...
Significance Cerebral arteriovenous malformations (AVMs) are common vascular abnormalities that may lead to strokes. Signaling by bone morphogenetic proteins (BMPs) and Notch play important roles in the formation of cerebral AVMs, but cross-talk between pathways is poorly understood. We report gene deletion matrix Gla protein (MGP), a BMP inhibitor, causes AVMs mice activating activin receptor-like kinase 1, receptor. This activation enhances activity disrupts endothelial cell...
It is well established that transcriptional silencing of critical tumor suppressor genes by DNA methylation a fundamental process in the initiation lung cancer. However, involvement microRNAs (miRNAs) restoring abnormal patterns cancer not understood. Therefore, and since miRNA-101 complementary to 3'-untranslated region methyltransferase 3A (DNMT3A), we investigated whether could restore normal cell lines. Bioinformatics has indicated DNMT3A major target miR-101. In addition, overexpression...
The SRY (sex determining region Y)-box (SOX) transcription factors were first identified as critical regulators of male sex determination but are now known to play important role in vascular development and disease. SOX7, 17 18 essential endothelial differentiation SOX2 have emerged mediator endothelial-mesenchymal transitions (EndMTs), a mechanism that enables the endothelium contribute cells with abnormal cell disease such calcific vasculopathy. Here we review information on SOX EndMTs...
Aim: We aimed to identify novel exosomal circular RNAs for hepatocellular carcinoma (HCC) diagnosis. Materials & methods: Exosomes were extracted and characterized. The expression level of circRNAs verified via quantitative real-time PCR. diagnostic value candidate was evaluated according the receiver operating characteristic curve analysis. Results: circ_0070396 significantly elevated in HCC patients than other control groups it performed better distinguishing from healthy donors that...
Chemoimmunotherapy can synergistically enhance the therapeutic effects and decrease side by a combined method. However, effective targeted codelivery of various chemotherapeutic agents siRNAs remains challenging. Although nanomedicine-based chemoimmunotherapy has shown great potential in cancer treatment recent years, further effort is needed to simplify nanocarrier designs maintain their functions. Here, we report simple but robust multifunctional liposomal that contains pH-sensitive...
Parkinson's disease (PD) represents the second most widespread neurodegenerative disease, and early monitoring diagnosis are urgent at present. Tyrosine hydroxylase (TH) is a key enzyme for producing dopamine, levels of which can serve as an indicator assessing severity progression PD. This renders specific detection visualization TH strategically vital way to meet above demands. However, fluorescent probe still missing. Herein, three rationally designed wash-free ratiometric probes were...
miRNAs (miR) play a critical role in human cancers, including hepatocellular carcinoma. Although miR-302b has been suggested to function as tumor repressor other its carcinoma is unknown. This study investigated the expression and functional of The level dramatically decreased clinical specimens, compared with their respective nonneoplastic counterparts, cell lines. Overexpression suppressed proliferation G1-S transition vitro, whereas inhibition promoted transition. Using luciferase...
Acute paraquat (PQ) poisoning is one of the most common forms pesticide poisoning. Oxidative stress and inflammation are thought to be important mechanisms in PQ-induced acute lung injury (ALI). Selenium (Se) can scavenge intracellular free radicals directly or indirectly. In this study, we investigated whether porous Se@SiO2 nanospheres could alleviate oxidative ALI. Male Sprague Dawley rats RLE-6TN cells were used study. Rats categorized into 3 groups: control (n=6), PQ (n=18), + (n=18)....
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with minimal treatment options and a global rise in prevalence. PDAC characterized by frequent driver mutations including KRAS TP53 (p53) , dense, acidic tumor microenvironment (TME). The relation between genotype TME development unknown. Strikingly, when wild type (WT) Panc02 cells were adapted to growth returned normal pH mimic invasive escaping regions, they displayed strong increase of traits such as...
MicroRNAs (miRNAs) are a class of small, non‑coding, endogenous RNAs that important in tumor cell biological processes as they regulate gene expression. miR-195 has been demonstrated to be repressor numerous types human cancer. However, the mechanism by which miR‑195 suppresses development remains elucidated. The aim this study was investigate effect on functions HepG2 hepatocellular carcinoma (HCC) cells and identify association between Wnt3a HCC. mRNA expression levels HCC tissues lines...
Lumen integrity in vascularization requires fully differentiated endothelial cells (ECs). Here, we report that endothelial-mesenchymal transitions (EndMTs) emerged ECs of cerebral arteriovenous malformation (AVMs) and caused disruption the lumen or disorder. We show excessive Sry-box 2 (Sox2) signaling was responsible for EndMTs AVMs. EC-specific suppression Sox2 normalized differentiation formation improved Epigenetic studies showed induction altered cerebral-endothelial transcriptional...
The acidic pH of the tumor microenvironment plays a critical role in driving cancer development toward more aggressive phenotype, but underlying mechanisms are unclear. To this end, phenotypic and genotypic changes induced by adaptation cells to chronic acidosis have been studied. However, generality acid patterns across cell models their correlation molecular phenotypes aggressiveness human cancers essentially unknown. Here, we define an expression response shared three models, dominated...