A5102805296- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- Regional Economic and Spatial Analysis
- COVID-19 and healthcare impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Childhood Cancer Survivors' Quality of Life
- Nanoplatforms for cancer theranostics
- COVID-19 Impact on Reproduction
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Disaster Response and Management
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Lymphoblastic Leukemia research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 and Mental Health
- Aortic aneurysm repair treatments
- Prion Diseases and Protein Misfolding
- Pharmaceutical studies and practices
- Gynecological conditions and treatments
- SARS-CoV-2 detection and testing
- Infectious Encephalopathies and Encephalitis
- Colorectal Cancer Treatments and Studies
Nanjing Drum Tower Hospital
2021-2025
Shanghai Electric (China)
2025
Shanghai Jiao Tong University
2013-2024
Ruijin Hospital
2008-2024
Zhongnan Hospital of Wuhan University
2020-2024
Wuhan University
2020-2024
Army Medical University
2021-2023
Nanjing University of Chinese Medicine
2013-2023
Southwest Hospital
2022
Shanghai Children's Medical Center
2012-2021
Abstract Currently, there are no approved specific antiviral agents for 2019 novel coronavirus disease (COVID-19). In this study, ten severe patients confirmed by real-time viral RNA test were enrolled prospectively. One dose of 200 mL convalescent plasma (CP) derived from recently recovered donors with the neutralizing antibody titers above 1:640 was transfused to as an addition maximal supportive care and agents. The primary endpoint safety CP transfusion. second endpoints improvement...
Abstract Effective therapies capable of simultaneously inhibiting inflammation and promoting bone healing remain to be developed for inflammatory disease. Stem cell hold great promise a variety diseases, but their translation is hampered by low survival, rapid clearance, limited functional integration transplanted stem cells in target tissues. Herein, multifunctional hydrogel‐based niche engineering strategy reported the treatment loss. By rationally integrating different modules, an...
Serum response factor (SRF) controls gene transcription in vascular smooth muscle cells (VSMCs) and regulates VSMC phenotypic switch from a contractile to synthetic state, which plays key role the pathogenesis of cardiovascular diseases (CVD). It is not known how post-translational SUMOylation SRF activity CVD. Here we show that Senp1 deficiency VSMCs increased SUMOylated SRF-ELK complex, leading augmented remodeling neointimal formation mice. Mechanistically, SENP1 increases at lysine 143,...
The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously,...
Abstract Asherman's syndrome (AS) occurs as a consequence of severe damage to the endometrial basalis, usually leading menstrual abnormalities, infertility, and recurrent miscarriage in women. Currently, human endometrium‐derived adventitial cells (En‐ADVs) are considered ideal seed with high pluripotency for regenerative medicine. However, critical issues such noninvasive repair tissues, targeting native stem cells, continuous action injured sites not well resolved. Herein, En‐ADV...
To explore an effective personalized training model for nurses working in emergency isolation wards of COVID-19 a short period.This study is longitudinal from 24 January 2020 to 28 February 2020.There are 71 nursing staff the Sichuan Provincial People's Hospital that participated this study. The questionnaires were conducted with Likert scale. operation assessment teachers have received standardized training. self-rating anxiety scale (SAS) and depression Scale (SDS) applied assess mental...
To understand how to implement proactive prevention measures among healthcare professionals for preventing potential nosocomial infection.91 confirmed with the COVID-19 infection were collected, and clinical characteristics epidemiological data evaluated.Among cases, 77 cases (84.6%) by viral nucleic acid test, other 14 diagnosed investigation. Ground glass opacity bilateral shadows distribution observed in 78 (85.6%). 56 (61.5%) admitted into Zhongnan Hospital subjected antiviral treatment....
To summarize the successful experience of timely crisis management, correct measures, and display hospital image in First Affiliated Hospital Zhejiang University (FAHZU), to improve ability emergency response.The FAHZU, as earliest designated hospital, accomplished transformation from general infectious disease under guiding ideology centralized patients, experts, resources, treatment with measures transfer Zhijiang campus hospitalized patients quickly, complete space layout, create...
The infection rate of Coronavirus Disease 2019 (COVID-19) in children was less than that adults. However, the underlining reason is not well known.Children with COVID-19 were recruited from two Children's Hospitals Wuhan and Shanghai this case-control study. associations initial symptoms age, vaccinations Bacillus Calmette Guerin (BCG), influenza pathogens determined by Chi-square t-test.We evaluated 248 confirmed cases, 56 suspected cases COVID-19. median age 6.82 years old, 118 (38.82%)...
Previous studies have confirmed that adiponectin (APN) plays a protective role in myocardial ischaemia-reperfusion (IR) injury, and the aim of this study was to investigate its effect on skeletal muscle. ELISA used detect levels Creatinine Kinase (CK), LDH, SOD MDA plasma lower limbs mice, IL-6, IL-1β TNF-α gastrocnemius. Quantitative PCR expression level miR-21. TUNEL staining apoptosis The proteins, autophagy marker proteins downstream target genes miR-21 gastrocnemius were detected by...
Suppressor of cytokine signaling-1 (SOCS1) is a protein that negatively regulates and growth factor signaling. However, little known regarding the precise role it plays in idiopathic pulmonary fibrosis. The aim present study was to construct recombinant lentiviral vector for RNA interference targeting SOCS1 gene detect expression human alveolar epithelial cells. A vector-mediated method used establish SOCS1-negative cell line origin (A549). Three pairs complementary small hairpin (shRNA)...
A prediction of the number patients with conjunctivitis plays an important role in providing adequate treatment at hospital, but such accurate predictive model currently does not exist. The current study sought to use machine learning (ML) based on past patient for and several air pollutants. optimal was selected predict conjunctivitis-related patients.The average daily pollutants concentrations (CO, O3, NO2, SO2, PM10, PM2.5) weather data (highest lowest temperature) were collected. Data...
Objective To investigate if type Ⅱ alveolar epithelial cells express Toll-like receptor 4( TLR4 ) and to the role of in airway inflammation chronic obstructive pulmonary diseases (COPD). Methods A549, line human were cultured divided into 3 groups: normal control group, E1A+ group transfected with adenovirus E1A plasmid, E1A- transferred blank plasmid without E1A. Lipopolysaccharide (LPS) concentrations 0, 0. 1, 10 μg/ml, IL-1 β 1 ng / ml, cigarette smoking extract (CSE) 10%, 20 %, 40% used...
COVID-19 is caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and manifests primarily as lung injury with diffuse interstitial disease evident in imaging. Patients often present clinical features similar to those autoimmune diseases share imaging, treatment serological similarities autoimmune-related diseases. The association between abnormalities post-COVID-19 pulmonary fibrosis also recognized. This article provided a comprehensive review pathogenic...
Polyhexanide is a safe and effective wound care antiseptic commonly used in clinics as rinsing solution gel. However, the efficacy of treatment infected with MRSA (
By the end of 2022, China had made a pivotal decision to optimize COVID-19 policy. The dominant Omicron variant in at that time was highly transmissible. In this study, we aimed evaluate real-world safety and efficacy tixagevimab cilgavimab against background China.
This study aimed to describe the outcomes of high-risk patients with symptomatic or impending ruptured pararenal aneurysm and thoraco-abdominal aortic comorbidities unsuitable for conventional open surgery, using physician-modified endografts (PMEGs).A single-center retrospective analysis was conducted on 59 (mean age: 75 years; 47 males) treated PMEGs between 2017 2020. Data baseline characteristics, procedures, clinical follow-up were collected retrospectively analyze early (technical...