Jun Shen

ORCID: 0000-0002-5248-513X
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Research Areas
  • Pediatric health and respiratory diseases
  • Cardiac Arrest and Resuscitation
  • Traditional Chinese Medicine Studies
  • Medical Research and Treatments
  • Disaster Response and Management
  • Pharmaceutical Quality and Counterfeiting
  • Renal Transplantation Outcomes and Treatments
  • Dental Trauma and Treatments
  • Anorectal Disease Treatments and Outcomes
  • Dental Health and Care Utilization
  • Organ Transplantation Techniques and Outcomes
  • Pelvic floor disorders treatments
  • COVID-19 and Mental Health
  • Lung Cancer Treatments and Mutations
  • COVID-19 and healthcare impacts
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Multiple Myeloma Research and Treatments
  • Respiratory Support and Mechanisms
  • Patient Safety and Medication Errors
  • Intensive Care Unit Cognitive Disorders
  • Functional Brain Connectivity Studies
  • Medical Malpractice and Liability Issues
  • COVID-19 Clinical Research Studies
  • Colorectal Cancer Surgical Treatments
  • Traumatic Ocular and Foreign Body Injuries

Wuhan University
2011-2020

Zhongnan Hospital of Wuhan University
2011-2020

University of Cambridge
2020

Bridge University
2020

Zhoushan Hospital
2004

Background and Purpose- Cerebrovascular disease contributes to age-related cognitive decline, but the mechanisms underlying this phenomenon remain incompletely understood. We hypothesized that vascular risk factors would lead impairment through disruption of brain white matter network efficiency. Methods- Participants were 19 346 neurologically healthy individuals from UK Biobank underwent diffusion MRI testing (mean age=62.6). Global efficiency, a measure integration, was calculated...

10.1161/strokeaha.119.028587 article EN cc-by-nc Stroke 2020-05-11

Recent evidence indicates that the epithelial to mesenchymal transition (EMT) in primary alveolar cells (AECs) plays an important role idiopathic pulmonary fibrosis (IPF). In vivo models have suggested thalidomide (THL) has anti-fibrotic effects against fibrosis, but underlying mechanism of this effect is not clear. This study investigated whether THL regulates EMT and possible mechanisms process. CCL-149 were treated with TGF-β1 presence at indicated concentrations. was assessed by changes...

10.1038/s41598-017-15239-2 article EN cc-by Scientific Reports 2017-11-01

Invasive mechanical ventilation (IMV) is a lifesaving strategy for critically ill patients with coronavirus disease 2019 (COVID-19). We aim to report the case series of critical receiving IMV in Wuhan and discuss timing these patients.Data 657 admitted emergency intensive care unit Zhongnan Hospital isolated isolation wards Union from January 1 March 10, 2020, were retrospectively reviewed. All medical records 40 COVID-19 who required collected at different time points, including baseline...

10.1097/ta.0000000000002939 article EN Journal of Trauma and Acute Care Surgery 2020-09-11

// Qi Wang 1 , Yukun He 2 and Jun Shen 3 The 1st Department of Gastrointestinal Surgery, Renmin Hospital Wuhan University, Hubei Province, 430060, P.R. China General Zhongnan 430071, Emergency Center, Correspondence to: Shen, email: WuhanSJEC@163.com Keywords: surgical strategy, anal fistula, network meta-analysis Received: August 14, 2017      Accepted: September 23, Published: October 12, 2017 ABSTRACT Objective: To determine a superior treatment for fistula...

10.18632/oncotarget.21836 article EN Oncotarget 2017-10-12

To understand how to implement proactive prevention measures among healthcare professionals for preventing potential nosocomial infection.91 confirmed with the COVID-19 infection were collected, and clinical characteristics epidemiological data evaluated.Among cases, 77 cases (84.6%) by viral nucleic acid test, other 14 diagnosed investigation. Ground glass opacity bilateral shadows distribution observed in 78 (85.6%). 56 (61.5%) admitted into Zhongnan Hospital subjected antiviral treatment....

10.1155/2020/8469560 article EN cc-by BioMed Research International 2020-10-08

Objective To investigate a reproducible model of severe crush injury (CI) in rats.Methods A total 50 clean grade male SD rats were randomly (random number) divided into 5 groups.Both hindlimbs anesthetized compressed by blocks weighing 3.5 kg,for 6 hours and followed 3 reperfusion on specially notched device (group SP,n =10),ordinary compression NM,n =10) simple control SHAM,n =10).Arterial tension,serum lactate,and potassium (K+),serum myoglobin (MB),aspartate transferase (AST) alanine...

10.3760/cma.j.issn.1671-0282.2014.03.012 article EN Zhonghua jizhen yixue zazhi 2014-03-10
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