Abstract Background Excessive oxidative stress at the wound sites always leads to a prolonged healing and even causes chronic inflammatory wounds. Therefore, antioxidative dressings with multiple features are desired improve performance. Herein, we fabricated ROS-scavenging hybrid hydrogel by incorporating mussel-inspired fullerene nanocomposites (C60@PDA) into gelatin methacryloyl (GelMA) hydrogel. Results The developed C60@PDA/GelMA showed sustainable free radical scavenging ability,...

The treatment of postoperative infection caused by multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), has become an intractable clinical challenge owing to its low therapeutic efficacy and high risk recurrence. Apart from imperfect antibacterial therapies, induction insufficient immunogenicity, required for the successful clearance a pathogen, may also contribute problem. Herein, ultra-micro photosensitizer, AgB nanodots, using photothermal therapy,...

Despite ongoing changes in the global epidemiology of cystic echinococcosis (CE), there is a lack research conducted to date.

Diabetes represents a global health crisis that necessitates advancements in prevention, treatment, and management. Beyond glucose regulation, addressing weight management associated complications is imperative. This study introduces an oral nanoparticle formulation designed to simultaneously control blood glucose, obesity, metabolic dysfunction. These nanoparticles, based on poly (zwitterion-cholic acid), incorporate polyzwitterion component enhance permeation through the mucus layer...

Abstract Background Bacterial infection, complex wound microenvironment and persistent inflammation cause delayed healing scar formation, thereby disrupting the normal function appearance of skin tissue, which is one most problematic clinical issues. Although Ag NPs have a strong antibacterial effect, they tend to oxidize form aggregates in aqueous solution, reduces their efficacy increases toxicity tissues organs. Current research on treatment limited mainly relies growth factors drugs...

Abstract Volumetric muscle loss (VML) is a severe form of trauma that exceeds the regenerative capacity skeletal tissue, leading to substantial functional impairment. The abnormal immune response and excessive reactive oxygen species (ROS) accumulation hinder regeneration following VML. Here, an interfacial cross‐linked hydrogel‐poly(ε‐caprolactone) nanofiber composite, incorporates both biophysical biochemical cues modulate ROS microenvironment for enhanced VML repair, engineered....

The present study aimed to investigate whether magnesium isoglycyrrhizinate protects against renal ischemia‑reperfusion injury (RIRI), and verify the underlying mechanisms. An RIRI rat model was induced by removing right kidney, exposing clamping left kidney. rats were administered 30 mg/kg for 3 days. Blood urea nitrogen (BUN) serum creatinine levels in blood of examined, compared with sham‑operated controls. Magnesium suppressed activities tumor necrosis factor‑α, interleukin (IL)‑1β,...

Invasive mechanical ventilation (IMV) is a lifesaving strategy for critically ill patients with coronavirus disease 2019 (COVID-19). We aim to report the case series of critical receiving IMV in Wuhan and discuss timing these patients.Data 657 admitted emergency intensive care unit Zhongnan Hospital isolated isolation wards Union from January 1 March 10, 2020, were retrospectively reviewed. All medical records 40 COVID-19 who required collected at different time points, including baseline...

The present study investigated the relationship between connexin 43 (Cx43) expression in alveolar type II epithelial cells (ATII) and air-blood barrier permeability, effect of microRNA-206 (miR-206) on Cx43 sepsis-induced acute lung injury. For vivo study, rats were divided into sham, caecum ligation perforation (CLP), CLP+Cx43 inhibitors (Cx43-In) CLP+miR-206 analogs (miR-206-Mi) groups. CLP method was used to prepare an injury model sepsis. Following successful modeling, tissue collected...

Background: Colorectal cancer (CRC) is one of the most common cancers. Cellular senescence plays a vital role in carcinogenesis by activating many pathways. In this study, we aimed to identify biomarkers for predicting survival and recurrence CRC through cellular senescence-related genes. Methods: Utilizing The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, RNA-sequencing data clinical information were collected. A risk model overall was established based on five...

The removal of small foreign bodies embedded within the deep soft tissues maxillofacial region is a complex and challenging task for surgeons. purpose this study was to explore efficacy combination intraoperative CT surgical navigation objects in region.

Breast cancer holds the highest incidence rate among women. Doxorubicin (DOX) is a potent frontline drug for treatment of breast cancer. The anticancer mechanisms DOX include inducing immunogenic cell death in tumor cells, causing damage to DNA, and generating free radicals. However, its pharmacological efficacy wide use are restricted by substantial dose-dependent side effects. We have recently revealed that 1,7-Heptanediol (1,7-Hept) severely impairs bioenergetics metabolism aggressive...

Severe heat stroke (HS) consists of extreme hyperthermia with thermoregulatory failure, leading to high morbidity and mortality. Liver injury is a complication HS that associated inflammatory responses Kupffer cells (KCs), which are resident macrophages in the liver serve as major source cytokines; however, association underlying mechanisms KC functions HS‑induced endotoxemia inflammation require an improved understanding. The important chemokine macrophage protein‑1α (MIP‑1α) increases...

Acute lung injury caused by sepsis remains one of the most difficult challenges faced patients in intensive care units and is associated with a high mortality rate. The aim present study was to investigate whether programmed cell death (PD)‑1/programmed death‑ligand 1 (PD‑L1) inhibitors reduce alveolar macrophage apoptosis, inflammatory factor release relieve inflammation. For this purpose, murine macrophages, MH‑S, were cultured divided into control, lipopolysaccharide (LPS) LPS+BMS‑1...

Small interfering RNA (siRNA) can specifically silence disease gene expression. This project investigated the overexpression of programmed death receptor ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) on surface tumor cells. However, main obstacle to development therapy drugs is lack an efficient delivery vector, which should be able overcome multiple barriers protect siRNA enter target Therefore, a novel fluorine-modified endogenous molecular carrier TFSPEI was constructed...

The current study investigated the protective effects of inactivated pseudomonas aeruginosa (IPA) on myocardial ischemia reperfusion injury (MIR/I) and mechanisms governing this interaction. Left anterior descending coronary artery ligation was performed rats for 30 min a subsequent 2 h. Rat hearts were obtained infarction area determined using nitroblue tetrazolium. Myocardial cell apoptosis flow cytometry. Malondialdehyde (MDA) content, lactate dehydrogenase (LDH) activity, superoxide...

Background Benign breast lesions are often associated with hard nodule formation after microwave ablation (MWA), which persists for a long time and causes problems in patients. The aim of this study was to evaluate the efficacy decorin treatment its potential mechanism action.Methods Using Bama miniature pig model mammary gland hyperplasia, immunohistochemistry, Masson's trichrome western blotting were firstly applied compare extent fibrosis activation key members TGF-β1/SMAD MAPK signaling...

Dynamic voltage and frequency scaling (DVFS) is an effective approach to balance the performance power consumption of CPU-GPU-based video rendering applications. Operating System (OS) based DVFS governors are general in nature thus lack regulation effectiveness for workload with different characteristics. Reinforcement learning (RL) enhances management ability application-specific DVFS, whereas robustness limited due partial observability complex SoCs. To mitigate this issue, paper, a deep...

Background: Osteoporotic vertebral compression fractures (OVCFs) are the most common type of fragility fracture. Distinguishing between OVCFs and other types vertebra diseases, such as old (OFs), Schmorl's node (SN), Kummell's disease (KD), previous surgery (PS), is critical for subsequent treatment. Combining with advanced deep learning (DL) technologies, this study plans to develop a DL-driven diagnostic system diagnosing multi-type diseases. Methods: We established large-scale dataset...