A5053872563- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Magnesium Alloys: Properties and Applications
- Bone health and treatments
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- Hip disorders and treatments
- Titanium Alloys Microstructure and Properties
- Molecular spectroscopy and chirality
- Spectroscopy and Quantum Chemical Studies
- Spectroscopy and Chemometric Analyses
- Parathyroid Disorders and Treatments
- Analytical Chemistry and Chromatography
- Bone fractures and treatments
- melanin and skin pigmentation
- Circular RNAs in diseases
- Antimicrobial Resistance in Staphylococcus
- Electrospun Nanofibers in Biomedical Applications
- Ophthalmology and Visual Impairment Studies
- Antimicrobial Peptides and Activities
- Bone and Joint Diseases
- NF-κB Signaling Pathways
Renji Hospital
2009-2025
Shanghai Jiao Tong University
2016-2025
University of Jinan
2021-2024
Binzhou Medical University
2020-2024
Binzhou University
2020-2024
Jiangmen Central Hospital
2023
Shanghai Ninth People's Hospital
2012-2021
Science and Technology Department of Sichuan Province
2016
SAIC-GM (China)
2011
University of Rhode Island
2000
Abstract Magnesium-based biodegradable metals (BMs) as bone implants have better mechanical properties than polymers, yet their strength is roughly less 350 MPa. In this work, binary Zn alloys with alloying elements Mg, Ca, Sr, Li, Mn, Fe, Cu, and Ag respectively, are screened systemically by in vitro vivo studies. Li exhibits the most effective strengthening role Zn, followed Mg. Alloying leads to accelerated degradation, but adequate integrity can be expected for when considering fracture...
Bone defects are commonly caused by severe trauma, malignant tumors, or congenital diseases and remain among the toughest clinical problems faced orthopedic surgeons, especially when of critical size. Biodegradable zinc-based metals have recently gained popularity for their desirable biocompatibility, suitable degradation rate, favorable osteogenesis-promoting properties. The biphasic activity Sr promotes osteogenesis inhibits osteoclastogenesis, which imparts Zn-Sr alloys with ideal...
Porous tantalum implants are a class of materials commonly used in clinical practice to repair bone defects. However, the cumbersome and problematic preparation procedure have limited their widespread application. Additive manufacturing has revolutionized design process orthopedic implants, but pore architecture feature porous scaffolds prepared from additive for optimal osseointegration unclear, particularly influence porosity. We trabecular bone-mimicking with three different porosities...
Abstract Reconciling the dilemma between rapid degradation and overdose toxicity is challenging in biodegradable materials when shifting from bulk to porous materials. Here, we achieve significant bone ingrowth into Zn-based scaffolds with 90% porosity via osteoinmunomodulation. At microscale, an alloy incorporating 0.8 wt% Li employed create a eutectoid lamellar structure featuring LiZn 4 Zn phases. This microstructure optimally balances high strength immunomodulation effects. mesoscale,...
Black phosphorus is well known for its excellent electromechanical properties. Although it has previously been used therapeutic drug delivery in cancer, never applied as an electroactive polymer post-trauma tissue regeneration (e.g., cardiac muscles and neurons). The major concern currently preventing such applications controversial biosafety profile vivo. Here, we demonstrate the production of a concentrically integrative layer-by-layer bioassembled black nanoscaffold. This scaffold...
ABSTRACT Periprosthetic infection remains a challenging clinical complication. We investigated the antibacterial properties of pure (99.9%) magnesium (Mg) in vitro and an vivo rat model implant-related infection. Mg was highly effective against methicillin-resistant Staphylococcus aureus -induced osteomyelitis improved new peri-implant bone formation. Bacterial icaA agr RNAIII transcription levels were also assessed to characterize mechanism underlying implant.
Osteoclasts play a pivotal role in diseases such as osteoporosis, rheumatoid arthritis and tumour bone metastasis. Thus, searching for natural compounds that may suppress osteoclast formation and/or function is promising the treatment of osteoclast-related diseases. Here, we examined changes osteoclastogenesis LPS-induced osteolysis response to andrographolide (AP), diterpenoid lactone isolated from traditional Chinese Indian medicinal plant Andrographis paniculata.Effects AP on...
The purpose of this hospital-based case-control study was to evaluate the risk factors for periprosthetic joint infection (PJI) total hip arthroplasty (THA) and knee (TKA) in Chinese patients.From January 2000 December 2012, 45 patients undergoing THA TKA who developed PJI were recruited case subjects; controls 252 without PJI, matched by year index surgery type surgery. Conditional logistic regressions run compute odds ratios (ORs) 95% confidence intervals (CIs).Demographic comorbid...
Revision THA is particularly challenging in hips with severe acetabular bone loss. When the extent or geometry of loss precludes more-straightforward techniques such as jumbo hemispheric cementless shells, reconstruction morselized allograft protected by a custom cage may offer an alternative, but, to our knowledge, few series have reported on results this approach.For patients (Paprosky IIIB) defects, we asked: do individualized cages result (1) improved Harris hip scores; (2) restoration...
Relatively slow degradation rate and delayed osseointegration induced by excessive release of Zn2+ ions are two main disadvantages the use pure Zn ion bioabsorbable orthopedic implants. In light this, we designed a cathodic protection strategy incorporating Mg, acting as sacrificial anode, into to form Zn-Mg composites. The performance novel composites with regard behavior biocompatibility was evaluated systematically under in vitro vivo conditions. Macro-galvanic coupling that formed...
Abstract Peripheral nerve injury is a common clinical problem bringing heavy burden to patients, due its high incidence and unsatisfactory treatment. Nerve guidance conduit (NGC) promising scaffold for peripheral repair, bioactive agents are applied great functional recovery. Melatonin (MLT) Fe 3 O 4 magnetic nanoparticles (Fe ‐MNPs) proven inhibit oxidative stress, inflammation, induce regeneration. Herein, multilayered composite NGC loaded with MLT ‐MNPs designed sequential sustainable...
The treatment of postoperative infection caused by multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), has become an intractable clinical challenge owing to its low therapeutic efficacy and high risk recurrence. Apart from imperfect antibacterial therapies, induction insufficient immunogenicity, required for the successful clearance a pathogen, may also contribute problem. Herein, ultra-micro photosensitizer, AgB nanodots, using photothermal therapy,...