A5067344928- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Sarcoma Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Cancer Cells and Metastasis
- Bone health and treatments
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Metabolism, Diabetes, and Cancer
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Orthopedic Infections and Treatments
- Cancer-related molecular mechanisms research
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Signaling Pathways in Disease
- Andrographolide Research and Applications
- Fibroblast Growth Factor Research
- Ion Transport and Channel Regulation
- Magnesium Alloys: Properties and Applications
- bioluminescence and chemiluminescence research
- NF-κB Signaling Pathways
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Shanghai Ninth People's Hospital
2013-2023
Shanghai Jiao Tong University
2013-2023
Sun Yat-sen University
2015-2019
First Affiliated Hospital of Dalian Medical University
2017
Guangdong Pharmaceutical University
2017
Dalian Medical University
2017
Shanghai Institutes for Biological Sciences
2008
The early detection and thus treatment of breast cancer bone metastasis remain a big challenge clinically. As the most abundant cells within tissue, osteocytes have been found to manipulate activity by its crosstalk with osteoclasts. However, conventional bone-targeting nanomedicine has limited bone-lesion specificity ignores vital role during metastasis. Also, it lacks detailed insight into therapeutic mechanisms, which hinders following translational practice. Previously, we shown that...
Osteoarthritis (OA) is an inflammatory disease of load-bearing synovial joints that currently treated with drugs exhibit numerous side effects and are only temporarily effective in treating pain, the main symptom disease. Consequently, there acute need for novel, safe, more chemotherapeutic agents treatment osteoarthritis related arthritic diseases. Curcumin, principal curcuminoid most active component turmeric, a biologically phytochemical. Evidence from several recent vitro studies...
Increasing evidence suggests that the tumor microenvironment plays a key role in development of drug resistant cells. In this study, we tried to determine whether mesenchymal stem cells (MSCs) contribute increased chemoresistance osteosarcoma. We found exposure Saos-2 and U2-OS MSCs conditioned medium (CM) viable presence therapeutic concentrations doxorubicin or cisplatin. Meanwhile, MSC CM-associated pro-proliferative effects were accompanied by reduced caspase 3/7 activity Annexin V...
The HACC-based multilayer could inhibit the colonization of bacteria <italic>via</italic> contact-killing and release-killing.
Abstract The loss of appropriate cell adhesion normally induces apoptosis via a process termed anoikis. aim this study was to investigate the effects mesenchymal stem cells (MSCs) in cancer microenvironment on anoikis resistance and pulmonary metastasis osteosarcoma (OS) cells, evaluate critical role interleukin (IL)-8/C-X-C chemokine receptor (CXCR) 1/Akt-signaling pathway these processes. Metastatic OS subtype which did or not interact with MSC-conditioned medium (MSC-CM) vitro, were...
Management of peritoneal carcinomatosis (PC) remains a significant clinical challenge due to lack effective therapies. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been identified as safe and efficacious treatment for PC. However, despite the observed high potential PIPAC in treating numerous PC cases, technology is still limited China. To address this deficit, we developed novel nebulized drug delivery system (NDDS) evaluated it study. The NDDS was systematically assessed...
The balance between osteogenesis and adipogenesis of bone marrow stromal cells is impaired in many human diseases. Knowledge how to fine-tune this medical importance. CCAAT/enhancer binding protein α (C/EBPα) has been shown regulate the C3H10T1/2 cells, with epigenetic modifications C/EBPα promoter playing an important role. present study aimed elucidate underlying molecular mechanisms. results showed that peroxisome proliferator-activated receptor γ (PPARγ) binds -1286 bp/-1065 bp region...
Breast cancer is one of the most common types worldwide. The majority patients with succumb to disease as a result distant metastases (for example, in bones), which cause severe complications. Despite advancements breast treatment, chemotherapeutic outcomes remain far from satisfactory, prompting search for effective natural agents few side‑effects. Andrographolide (AP), diterpenoid lactone isolated Andrographis paniculata, inhibits cell growth. current study aimed examine effect AP on...
Many skeletal diseases have common pathological phenotype of defective osteogenesis bone marrow stromal cells (BMSCs), in which histone modifications play an important role. However, few studies examined the dynamics distinct during osteogenesis. In this study, we H3K9/K14 and H4K12 acetylation; H3K4 mono-, di- tri-methylation; H3K9 di-methylation H3K27 tri-methylation osteogenic genes, runt-related transcription factor 2 (Runx2), osterix (Osx), alkaline phosphatase, sialoprotein...