Abstract Targeting subcellular organelle with multilevel damage has shown great promise for antitumor therapy. Here, we report a core-shell type of nanoagent iron (III) carboxylate metal-organic frameworks (MOFs) as shell while upconversion nanoparticles (UCNPs) core, which enables near-infrared (NIR) light-triggered synergistically reinforced oxidative stress and calcium overload to mitochondria. The folate decoration on MOFs shells efficient cellular uptake nanoagents. Based the ability...

The early detection and thus treatment of breast cancer bone metastasis remain a big challenge clinically. As the most abundant cells within tissue, osteocytes have been found to manipulate activity by its crosstalk with osteoclasts. However, conventional bone-targeting nanomedicine has limited bone-lesion specificity ignores vital role during metastasis. Also, it lacks detailed insight into therapeutic mechanisms, which hinders following translational practice. Previously, we shown that...

Abstract As membrane‐bound extracellular vesicles, exosomes have targeting ability for specific cell types, and the cellular environment strongly impacts their content uptake efficiency. Inspired by these natural properties, of various stress conditions on efficiency tumor iterated are evaluated, low‐pH treatment caused increased retained cell‐type specificity is found. Lipidomics analyses molecular dynamics simulations reveal a glycerolipid self‐aggregation‐based mechanism enhanced...

The aggregative instinct of platelets was exploited as a biomimetic strategy for synergistic combined therapy against cancer.

Abstract Circular RNAs (circRNAs) is one type of important non-coding that participate in tumorigenesis and cancer progression. In our previous study, we performed a microarray analysis circRNAs between the tumor tissues adjacent normal hepatocellular carcinoma (HCC) patients, found circRNA hsa_circ_0007456 significantly downregulated correlated with prognosis HCC. We further investigated relationship expression levels HCC susceptibility NK cells, cell lines influenced their to cells....

Abstract There are several attractive opportunities for using magnetic nanomaterials anticancer applications. Herein, a nanomaterial platform is successfully developed based on natural Fe 3 O 4 magnetosomes extracted from the bacterium Magnetospirillum magneticum AMB‐1 therapy. The authors initially functionalize magnetosome membranes in situ with gold nanoparticles to construct an core‐satellite structure. Subsequently, physical properties and application potentials of these structures...

Abstract Background The tetraspanin family plays a pivotal role in the genesis of migrasomes, and Tetraspanin CD151 is also implicated neovascularization within tumorous contexts. Nevertheless, research pertaining to involvement hepatocellular carcinoma (HCC) its association with migrasomes remains inadequate. Methods To investigate correlation between migrasome marker TSPAN4 liver cancer, we conducted database analysis using clinical data from HCC patients. Expression levels were assessed...

In this study, a nanocalcium silicate (n-CS)/polyetheretherketone (PEEK) bioactive composite was prepared using process of compounding and injection-molding. The mechanical properties, hydrophilicity, in vitro bioactivity the composite, as well cellular responses MC3T3-E1 cells (attachment, proliferation, spreading, differentiation) to were investigated. results showed that properties hydrophilicity composites significantly improved by addition n-CS PEEK. addition, an apatite-layer formed on...

Layered ternary Mn+1AXn (MAX) materials are recently proposed to be promising candidates for future fission and fusion programmes because of their unique properties inherited from both ceramics metals. However, different demonstrate behaviors when exposed energetic neutron or ion irradiations. Based on first-principles calculations, we have investigated the irradiation tolerance two typical materials: Ti3SiC2 Ti3AlC2 aspects. First, make a detailed analysis interatomic bonding characters,...

As a widely used absorbable suture with antibacterial property, triclosan- coated polyglactin (Vicryl Plus) has been extensively utilized to reduce the occurrence rate of surgical site infections (SSIs) in orthopaedic surgery. However, potential toxicity and side-effects triclosan raised increasing concerns about its biological safety. This study aimed investigate antimicrobial activity biocompatibility quaternised chitosan-coated Vicryl (HV) both

Reactive oxygen species (ROS) are key contributors to inflammatory progression and damage. Upon clinical experimental observation of vascular abnormalities in acute diseases, we explore cellular vesicles as templates carriers elevate therapeutic performance nano-antioxidant. Specifically, develop a mild one-pot approach for situ growth cerium oxide (Ce) nanocrystals onto nano-sized red blood cells (ReVs). Besides excellent biocompatibility, Ce-ReVs have very high ROS-scavenging activity,...

Ferritin (Fn) is considered a promising carrier for targeted delivery to tumors, but the successful application in vivo has not been fully achieved yet. Herein, strong evidence provided that Fn receptor expressed liver tissues, resulting an intercept effect regards tumor delivery. Building on these observations, biomineralization technology rationally designed shield using calcium phosphate (CaP) shell, which can improve performance by reducing interception while re-exposing it acidic...

Bone-related infection rates are 4-64% in long open bone fractures and nearly 1% joint-related surgeries. Treating infections infection-related loss is very important. The present study prepared strontium ranelate (SR)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (PM) with assembled silver nanoparticles (AgNPs) hydroxyapatite (HANPs) (SR-PM-Ag-HA) through a novel solid-in-oil nanosuspension (S/O/N) method to achieve osteoinductivity antibacterial properties. We evaluated the...

Abstract Gouty arthritis is a rheumatic disease that characterized by the deposition of monosodium urate (MSU) in synovial joints cause increased serum hyperuricemia. This study used three-dimensional (3D) flowing microfluidic chip to screen effective candidate against MSU-stimulated human umbilical vein endothelial cell (HUVEC) damage, and found kinsenoside (Kin) be leading active component Anoectochilus roxburghi , one Chinese medicinal plant widely treatment gouty clinically. Cell...

Exosomes (Exos) are nanosized vesicles (around 100 nm) that recently serve as a promising drug carrier with high biocompatibility and low immunogenicity. Previous studies showed Exos secreted from mesenchymal stem cells (MSCs) provide protection for concanavalin A (Con A)-induced liver injury. In this study, the protective effect of is confirmed, dexamethasone (DEX)-incorporated named Exo@DEX prepared. It then investigated whether can function more efficiently compared to free drugs naive in...

Delayed skin healing in diabetic wounds is a major clinical problem. The tRNA-derived small RNAs (tsRNAs) were reported to be associated with diabetes. However, the role of tsRNAs wound unclear. Our study was designed explore tsRNA expression profile and mine key potential their mechanism wounds.Skin tissues patients foot ulcers healthy controls subjected RNA sequencing. candidate explored by loss- gain-of-function experiments HUVECs.A total 55 differentially expressed identified, including...

Abstract Tryptophan metabolism is an essential regulator of tumor immune evasion. However, the effect tryptophan on cancer cells remains largely unknown. Here, we find that have distinct responses to deficiency in terms cell growth, no matter hepatocellular carcinoma (HCC) cells, lung or breast cells. Further study shows ERRFI1 upregulated sensitive HCC but not resistant response deficiency, and expression level positively correlates with patient overall survival. knockdown recovers...

Ebselen is a seleno-organic compound that has been demonstrated to have antioxidant and anti-inflammatory properties. A previous study determined ebselen inhibits airway inflammation induced by inhalational lipopolysaccharide (LPS), however, the underlying molecular mechanism remains be elucidated. The present investigated effect of on glutathione peroxidase (GPX)‑reactive oxygen species (ROS) pathway interleukin‑8 (IL‑8) expression Helicobacter pylori LPS in gastric cancer (GC) cells. Cells...

To further observe and verify the effect of nonalcoholic fatty liver disease (NAFLD) on response to antiviral therapy in patients with chronic hepatitis B (CHB) investigate relationship between virologic insulin resistance.A retrospective study was adopted 61 NAFLD HBeAg-positive CHB were included as observation group (group A), 64 simple control B).After 12 weeks treatment entecavir, total rate A statistically significantly lower than that (P<0.05). During 24-96, difference not significant...

Recent researches have demonstrated that inflammation-related diseases are effectively regulated by posttranslational modifications (PTMs) including phosphorylation and acetylation. Our previous study found a new acetyltransferase inhibitor, oridonin, which had protective effect on acute liver injury (ALI). In the present study, we further investigated its mechanism against D-galactosamine (D-Gal) combined with lipopolysaccharide- (LPS-) induced ALI in mice.Intraperitoneal injections of LPS...

Liver cancer is one of the most common malignant tumors, and which hepatocellular carcinoma (HCC). We aim to study characteristic changes numerous genes their roles in HCC through systematical analysis characteristics expression spectrum HCC. Firstly, we made systematic clustering samples according RNAseq data from TCGA (The Cancer Genome Atlas) newly classified Then different molecular subtypes were found out further analyzed combing with methylation SNP 6.0 chip. Finally, these subjected...