A5082277434- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Heavy Metal Exposure and Toxicity
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Health, Environment, Cognitive Aging
- Indoor Air Quality and Microbial Exposure
- Adipose Tissue and Metabolism
- Air Quality Monitoring and Forecasting
- Glutathione Transferases and Polymorphisms
- Liver physiology and pathology
- Trace Elements in Health
- Genomics, phytochemicals, and oxidative stress
- Noise Effects and Management
- Drug Transport and Resistance Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience and Neuropharmacology Research
- PARP inhibition in cancer therapy
Sun Yat-sen University
2016-2025
Shanghai Children's Hospital
2020-2025
Shanghai Jiao Tong University
2025
Shandong University
2022
In-Q-Tel
2014-2016
Sun Yat-sen University Cancer Center
2016
National Center for Toxicological Research
2007-2015
Shenzhen Center for Disease Control and Prevention
2012
National Institute for Occupational Health and Poison Control
2012
All humans are now co-exposed to multiple toxic chemicals, among which metals and polycyclic aromatic hydrocarbons (PAHs) of special concern as they often present at high levels in various human environments. They can also induce similar early health damage, such genetic oxidative stress, heart rate variability (HRV). Exposure metals, PAHs, their combined pollutants alter microRNA (miRNA) expression patterns. To explore the associations metal-PAH co-exposure with miRNA expression, associated...
Identification of aberrant microRNA (miRNA) expression during chemical carcinogen–induced cell transformation will lead to a better understanding the substantial role miRNAs in cancer development. To explore whether can be used as biomarkers exposure risk assessment carcinogenesis, we analyzed miRNA profiles human bronchial epithelial cells expressing an oncogenic allele H-Ras (HBER) at different stages induced by benzo(a)pyrene (BaP) array. It revealed 12 differentially expressed HBER both...
Abstract Background: Sufficient epidemiologic evidence shows an etiologic link between polycyclic aromatic hydrocarbons (PAH) exposure and lung cancer risk. While the genetic modifications have been found in PAH-exposed population, it is unclear whether gene-specific methylation involves process of PAH-associated biologic consequence. Methods: Sixty-nine workers 59 control subjects were recruited. Using bisulfite sequencing, we examined status p16INK4α promoter peripheral blood lymphocytes...
To assess the carcinogenic potential of PM2.5 exposure, we developed a cell-based experimental protocol to examine cell transformation activity samples from different regions in China. The seasonal ambient were collected three megacities, Beijing (BJ), Wuhan (WH), and Guangzhou (GZ), November 2016 October 2017. mean concentrations much higher winter season (BJ: 109.64 μg/m3, WH: 79.99 GZ: 49.99 μg/m3) than that summer 42.40 25.82 19.82 μg/m3). organic extracts (OE) combined (S) (June, July,...
Di(2-ethylhexyl) phthalate (DEHP) is a widespread ubiquitous environmental contaminant. The male reproductive toxicity (MRT) from exposure to DEHP and its main metabolite, mono(2-ethylhexyl) (MEHP), has been well documented. Fully elucidating toxic mechanism discovering effective antagonists are desirable means reduce the health risks of DEHP. In this study, 552 genes related MRT induced by DEHP/MEHP were screened out Comparative Toxicogenomics Database (CTD) DisGeNET database. Next, we...
Objective: To summarize the clinical features, laboratory findings, treatment and prognosis of children confirmed as Mycoplasma pneumoniae-induced rash mucositis (MIRM) in children. Methods: This retrospective study concluded 6 diagnosed MIRM Department Gastroenterology Infectious Diseases, Shanghai Children's Hospital, School Medicine, Jiao Tong University from August 2023 to April 2024. paper described characteristics analyzed therapeutic strategy prognosis. Results: A total were including...
Lead (Pb) is found to impair cognitive function. Synaptic structural plasticity considered be the physiological basis of synaptic functional and has been recently play important roles in learning memory. To study effect Pb on spatial memory at different developmental stages, its relationship with alterations plasticity, postnatal rats were randomly divided into three groups: Control; Pre-weaning (Parents exposed 2 mM PbCl2 3 weeks before mating until weaning pups); Post-weaning (Weaned pups...
To explore whether the alteration of lncRNA expression is correlated with polycyclic aromatic hydrocarbons (PAHs) exposure and DNA damage, we examined PAHs external internal exposure, damage lncRNAs (HOTAIR, MALAT1, TUG1 GAS5) in peripheral blood lymphocytes (PBLCs) 150 male coke oven workers 60 non-PAHs workers. We found HOTAIR, were enhanced PBLCs positively levels (adjusted Ptrend < 0.001 for HOTAIR adjusted = 0.006 TUG1). However, only MALAT1 significantly associated level (urinary...