A5028071079- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Ergonomics and Musculoskeletal Disorders
- Musculoskeletal pain and rehabilitation
- Occupational health in dentistry
- Advanced Chemical Sensor Technologies
- MicroRNA in disease regulation
- Climate Change and Health Impacts
- Hearing, Cochlea, Tinnitus, Genetics
- Circular RNAs in diseases
- Noise Effects and Management
- Heart Rate Variability and Autonomic Control
- Hearing Loss and Rehabilitation
- Indoor Air Quality and Microbial Exposure
- Air Quality Monitoring and Forecasting
- Occupational and environmental lung diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Heavy Metal Exposure and Toxicity
- Erythrocyte Function and Pathophysiology
- Heat shock proteins research
- Workplace Health and Well-being
- Diabetes and associated disorders
- Management of metastatic bone disease
- Cardiovascular and exercise physiology
Howard Hughes Medical Institute
2023
Primary Source
2023
Creative Commons
2023
Center for Disease Control
2021-2023
National Institute for Occupational Health and Poison Control
2023
Beijing Center for Disease Prevention and Control
2023
Chongqing Public Health Medical Center
2023
Chongqing Medical University
2023
National Institutes of Health
2023
Wellcome Trust
2023
Background Air pollution has been associated with an increased risk of cardiopulmonary mortality and decreased heart rate variability (HRV). However, it is unclear whether coke oven emissions (COEs) polycyclic aromatic hydrocarbons (PAHs) are HRV. Objectives Our goal in the present study was to investigate association exposure COEs urinary metabolite profiles PAHs HRV workers. Methods We measured benzene soluble matter, carbon monoxide, sulfur dioxide, particulate matters, at different...
Exposure to environmental polycyclic aromatic hydrocarbons (PAHs) has been associated with increased risk of cancer, but evidence for gender differences in this association is limited. The aim study was examine the PAHs caused early genotoxic effects such as oxidative stress and chromosome damage, which are potential carcinogenic etiology PAHs. A total 478 nonsmoking workers (272 men 206 women) from a coke oven plant were recruited. We determined 16 their workplaces, measured concentrations...
All humans are now co-exposed to multiple toxic chemicals, among which metals and polycyclic aromatic hydrocarbons (PAHs) of special concern as they often present at high levels in various human environments. They can also induce similar early health damage, such genetic oxidative stress, heart rate variability (HRV). Exposure metals, PAHs, their combined pollutants alter microRNA (miRNA) expression patterns. To explore the associations metal-PAH co-exposure with miRNA expression, associated...
Ubiquitous polycyclic aromatic hydrocarbons (PAHs) have been shown to alter gene expression patterns and elevate micronuclei (MN) frequency, but the underlying mechanisms are largely unknown. MicroRNAs (miRNAs) key regulators that may be influenced by PAH exposures mediate their effects on MN frequency.We sought identify PAH-associated miRNAs evaluate associations with performed a two-stage study in healthy male coke oven workers associated quantified using urinary monohydroxy-PAHs plasma...
The purpose of this study was to explore the relationship between skeletal muscle disorders (SMD), occupational stress (OS) and depressive symptoms (DS) among firefighters. A cross-sectional survey conducted firefighters in Chongqing, China. Descriptive statistic correlation analyses were performed by using SPSS 26.0. AMOS 24.0 used construct structural equation modeling SMD DS. mediating effect OS also evaluated. results demonstrate that can predict DS (β = 0.25, p < 0.001) 0.39,...
We previously identified five polycyclic aromatic hydrocarbons (PAHs)-associated microRNAs (miRNAs) and found they were associated with chromosome damage. As oxidative damage is the common contributory cause of various PAHs-related diseases, we further investigated influences these miRNAs their interactions environmental factors on DNA lipid peroxidation. measured PAHs internal exposure biomarkers [urinary monohydroxy-PAHs (OH-PAHs) plasma...
Objective: This study aims to determine the occupational health status of workers exposed dust and risk factors lung function decline, provide a basis for formulating corresponding disease-prevention strategies. Methods: Data on 2045 dust, including their age, gender, exposure time, chest X-ray test results, pulmonary were obtained from key disease monitoring project in Chongqing, China, 2021. Chi-square tests multifactorial logistic regression, other methods, used statistical analysis....
We sought to clarify the association of occupational formaldehyde exposure with DNA strand breaks, chromosome damage and DNA-protein crosslinks (DPCs) in peripheral blood (PB) lymphocytes plywood workers.We determined Olive tail moment (OTM) values, micronucleus (MN) frequencies DPC rates PB 178 workers divided into control lower higher groups according their current levels examined each end point number work years. also an additional 62 before after 8-hour for validating association.OTM...
Combined effect of elevated blood pressure and occupational noise exposure on hearing loss have rarely been evaluated among Chinese population.This cross-sectional study was conducted in 242,811 participants. Logistic regression model performed to estimate the independent combined associations.Compared with participants without exposure, risk bilateral high-frequency (BHFHL) significantly higher for 10 years or more (odds ratio [OR] = 1.29, 95% confidence interval [95% CI] 1.23-1.35)....
Multiple studies have established a strong relationship between circRNA and cancer progression. Cervical lymph node metastasis is key factor influencing the surgical approach distant of papillary thyroid (PTC). However, role circNDST1 in PTC has not been investigated. Our research focused on revealing function mechanism action PTC. High-throughput sequencing qPCR were used to assess expression tissues with extensive cervical cell lines, respectively. The proliferative effects vitro vivo...
HSPA1A (HSP70-1) is a highly inducible heat shock gene up-regulated in response to environmental stresses and pollutants. The aim of our study was evaluate the sensitivity stable metabolically competent HepG2 cells containing human promoter-driven luciferase reporter (HepG2-luciferase cells) for assessing toxicity organic pollutants present air. HepG2-luciferase were validated by treatment testing three compounds (pyrene, benzo[a]pyrene, formaldehyde) that are ubiquitous maximal level...
Objective This study aimed to understand the health of workers exposed occupational noise and explore influencing factors related workers’ health, especially impact on hearing. work can provide a basis for formulating relevant measures prevention control in future. Methods On key disease monitoring project Chongqing, China, 2021, data 1125 were analyzed. Data included demographic information, history, clinical physical examination detection information working environment. Chi-square test...
Occupational stress, cumulative fatigue, and work-related musculoskeletal disorders (WMSDs) are major concerns in the field of occupational health. Previous studies on health focused key industries, such as medical care, while there were few related Information Technology (IT) industry. Our study explored factors influencing IT We collected 1363 workers’ valid questionnaires, which 73.1% participants technicians Chongqing, 2021. The core stress scale (COSS), self-diagnosis checklist for...
BACKGROUND: The automotive industry is labor-intensive, and workers are involved in highly repetitive tasks, long hours, medium to low workloads, resulting work-related musculoskeletal disorders (WMSDs), which have become a major health concern for this industry. China country with tens of thousands auto repair workers, but their conditions WMSDs been poorly reported. OBJECTIVE: This work aimed analyze the current prevalence associated risk factors among automobile maintenance workers....
Radiation-induced bone injury (RIBI) is one of the complications after radiotherapy for malignant tumors. However, there are no effective measures treatment RIBI in clinical practice, and mechanism unclear. We use a single high-dose ionizing radiation (6Gy) to analyze effect on osteoblast function. Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) were cocultured with irradiated osteoblasts examine their therapeutic effects mechanisms injury. The hUCB-MSC transplantation mouse...
Objectives. This study aimed to identify the prevalence of multi-site work-related musculoskeletal disorders (WMSDs) in Chinese footwear industry workers from 2018 2020 and explore possible influencing factors WMSDs. Methods. 7106 subjects 26 large shoe factories China were investigated using epidemiological cross-sectional survey method by Nordic questionnaire (NMQ). Results. The total WMSDs was 36.8% (2616/7106). Among them, 26.1% (1858/7106). proportion involving two sites largest...
Abstract Object: To explore the prevalence and risk factors of work-related musculoskeletal disorders (WMSDs) among footwear industry workers in China, thereby providing a scientific basis for implementing health interventions. Methods Following cross-sectional epidemiological survey method, modified Chinese version WMSDs Questionnaire was adopted to investigate related such as ergonomic load psychosocial factors, all 26 factories across China from 2018 2020. The data were statistically...
Abstract BACKGROUND China remains the world’s largest automotive manufacturing country. The work-related musculoskeletal disorders (WMSDs) are a common occupational hazard associated with heavy industries. 76.2%-91.4% of vehicle maintenance workersuffers from WMSDs, among them, workers have higher risk WMSDs due to some uncomfortable working postures and unreasonable work schedules.Furthermore, prevalence multi-site is than that single-site in workers. available data (descriptive,...